Results 241 to 250 of about 3,142,470 (292)

Enviromics and Abiotic Enviromics: Enhancing Stress Biology and Plant Resilience Breeding

Advanced Science, EarlyView.
Environmental stressors are captured through high‐throughput envirotyping and integrated into an enviromic framework with genomic, transcriptomic, phenomic, and environmental data. AI/ML models enable prediction and guide marker‐assisted selection, genomic selection, genome editing, and gene pyramiding toward improved abiotic stress tolerance, yield ...
Guangchao Sun, Jose Luis Araus, James C. Schnable, Jie Xu, Henry T. Nguyen, Yunbi Xu, Yanli Lu   +6 more
wiley   +1 more source

Bioelectrical Regulation of Vascular Endothelial Function in Atherosclerosis. [PDF]

Biomolecules
Custodio JM, Liu JJ, Zhang L, Hong L.
europepmc   +1 more source

A Multiscale Mechanistic Framework for Polydopamine Dyeing in Ultrablack Wool Textiles

Advanced Science, EarlyView.
Ultrablack photonic textiles are enabled through polydopamine (PDA) dyeing, which is governed by the interplay of PDA chemistry, wool surface topology and chemistry, and hierarchical fiber–yarn–fabric architecture. Fabric architecture emerges as a primary and previously underappreciated design lever for wide‐angle optical performance.
Hansadi Jayamaha, Kumar Siddharth, Kyuin Park, Mia Bressler, Larissa M. Shepherd   +4 more
wiley   +1 more source

The cornea-trigeminal axis: potassium channels as master regulators of ocular surface homeostasis and sensory transduction. [PDF]

Front Cell Dev Biol
Zhang J, Chen X, Ji J, Chen P, Yao J, Liu L, Tang L, Wen X.   +7 more
europepmc   +1 more source

THE SULPHONYLUREA RECEPTOR MAY BE AN ATP-SENSITIVE POTASSIUM CHANNEL

The Lancet, 1985
The stimulation of insulin secretion from the beta cells of the islets of Langerhans appears to be mediated by a decrease in the cell-membrane potassium-ion permeability. Tolbutamide reduced K+ movement through an ATP-sensitive K+ channel in patches of plasma membrane from an insulin-producing cell line when applied to the external surface of the ...
Sturgess, Nicholas C., Cook, Daniel L., Ashford, Michael L. J., Hales, C. Nicholas   +3 more
openaire   +4 more sources

Regulation of cholecystokinin secretion by ATP-sensitive potassium channels

American Journal of Physiology-Gastrointestinal and Liver Physiology, 1994
The relationship of potassium channel activity to the secretion of cholecystokinin (CCK) was evaluated in STC-1 cells, an intestinal CCK-secreting cell line. Patch-clamp and 86Rb efflux studies showed that an ATP-sensitive potassium channel was endogenously expressed in STC-1 cells.
A W, Mangel, V, Prpic, N D, Snow, S, Basavappa, L J, Hurst, A I, Sharara, R A, Liddle   +6 more
openaire   +3 more sources

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The Pharmacology of ATP-Sensitive Potassium Channels

Annual Review of Pharmacology and Toxicology, 1993
A potassium (K) channel that was inhibited by physiological (f1M) concen­ trations of intracellular ATP ([ATP]i) and that opened as [ATP]i decreased was first described in the heart ( l). Subsequently, similar K -channels all with unitary conductances in the range of 40-80 pS (measured under symmetrical high K+ conditions) were also found to exist in ...
G, Edwards, A H, Weston
openaire   +3 more sources

ATP-Sensitive Potassium Channels

Current Pharmaceutical Design, 2005
ATP-sensitive potassium (K(ATP)) channels link membrane excitability to metabolism. They are regulated by intracellular nucleotides and by other factors including membrane phospholipids, protein kinases and phosphatases. K(ATP) channels comprise octamers of four Kir6 pore-forming subunits associated with four sulphonylurea receptor subunits.
Rodrigo, GC, Standen, NB
openaire   +3 more sources

The Emerging Structural Pharmacology of ATP-Sensitive Potassium Channels

Molecular Pharmacology, 2022
ATP-sensitive potassium channels (KATP) are energy sensors that participate in a range of physiologic processes. These channels are also clinically validated drug targets. For decades, KATP inhibitors have been prescribed for diabetes and KATP activators have been used for the treatment of hypoglycemia, hypertension, and hair loss.
Jing-Xiang Wu, Dian Ding, Lei Chen
openaire   +2 more sources

Regulation of the ATP-Sensitive Potassium Channel

1990
A new class of K+ channels that link membrane potential to the bioenergetic situation of the cell has recently been discovered. These K+ channels (KATP) are normally closed at physiological intracellular ATP concentrations and open upon a diminution of [ATP]in.
J R, de Weille, M, Lazdunski
openaire   +2 more sources