Results 261 to 270 of about 3,142,470 (292)

Role of ATP-sensitive potassium channels in the basilar artery

American Journal of Physiology-Heart and Circulatory Physiology, 1993
This study examined the hypothesis that activation of ATP-sensitive potassium channels produces vasodilation and contributes to dilator responses of the basilar artery to acetylcholine in vivo. Diameter of the basilar artery (baseline diam = 245 +/- 14 microns, means +/- SE) was measured through a cranial window in anesthetized rats. RP52891 (1 microM)
F M, Faraci, D D, Heistad
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ATP-sensitive potassium channels: metabolic sensing and cardioprotection

Journal of Applied Physiology, 2007
The cardiovascular system operates under a wide scale of demands, ranging from conditions of rest to extreme stress. How the heart muscle matches rates of ATP production with utilization is an area of active investigation. ATP-sensitive potassium (KATP) channels serve a critical role in the orchestration of myocardial energetic well-being.
L V, Zingman, A E, Alekseev, D M, Hodgson-Zingman, A, Terzic   +3 more
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ATP-SENSITIVE POTASSIUM CHANNELS: A Model of Heteromultimeric Potassium Channel/Receptor Assemblies

Annual Review of Physiology, 1999
▪ Abstract  ATP-sensitive K+ channels (KATP channels) play important roles in many cellular functions by coupling cell metabolism to electrical activity. By cloning members of the novel inwardly rectifying K+ channel subfamily Kir6.0 (Kir6.1 and Kir6.2) and the receptors for sulfonylureas (SUR1 and SUR2), researchers have clarified the molecular ...
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Blockade of Myocardial ATP-sensitive Potassium Channels by Ketamine 

Anesthesiology, 1997
Background The adenosine triphosphate (ATP)-sensitive potassium (KATP) channel underlies the increase in potassium permeability during hypoxia and ischemia. The increased outward potassium current during ischemia may be an endogenous cardioprotective mechanism.
S H, Ko, S K, Lee, Y J, Han, H, Choe, Y G, Kwak, S W, Chae, K P, Cho, H S, Song   +7 more
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ATP-sensitive potassium channels in physiology, pathophysiology, and pharmacology

Current Opinion in Nephrology and Hypertension, 1992
Potassium-selective ion channels, whose activity is inhibited by micromolar to millimolar concentrations of ATP presented at the cytoplasmic ATP-sensitive K+ (K+[ATP]) surface, have been found in a variety of cell types. These "K+(ATP) channels" have emerged as significant targets for physiologic as well as pharmacologic modulation of cell processes ...
S, Misler, G, Giebisch
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Amiodarone Inhibits Cardiac ATP‐Sensitive Potassium Channels

Journal of Cardiovascular Electrophysiology, 2000
Amiodarone Inhibition of Cardiac KATPChannels.Introdttction:ATP‐sensitive K+channels (KATP) are expressed abundantly in cardiovascular tissues. Blocking this channel in experinuntal models of ischemia can reduce arrhythmias. We investigated the acute effects of amiodarone on the activity of cardiac sarcolemmal KATPchannels and their sensitivity to ATP ...
D S, Holmes, Z Q, Sun, L M, Porter, N E, Bernstein, L A, Chinitz, M, Artman, W A, Coetzee   +6 more
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Involvement of ATP-sensitive potassium channels in preconditioning protection

Basic Research in Cardiology, 1994
Single or multiple brief periods of ischemia (preconditioning, PC) have been shown to protect the myocardium from infarction during a subsequent more prolonged ischemic insult. To test the hypothesis that opening of ATP-sensitive potassium channels (KATP) is involved in this mechanism, either bimakalim, a KATP channel opener, or glibenclamide, a KATP ...
S, Rohmann, H, Weygandt, P, Schelling, L, Kie Soei, P D, Verdouw, I, Lues   +5 more
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The Role of ATP Sensitive Potassium Channels in Myocardial Protection

Journal of Cardiac Surgery, 1995
Several factors have pointed to a potential link between ATP sensitive potassium channel activation in ventricular myocytes and the phenomenon of myocardial preconditioning. Preconditioning can be blocked by adenosine antagonists, and is mimicked by adenosine A1-receptor agonists.
B A, Cason, H J, Gordon, E G, Avery, R F, Hickey   +3 more
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Mitochondrial ATP-sensitive potassium channels in surgical cardioprotection

Archives of Biochemistry and Biophysics, 2003
ATP-sensitive potassium channels allow for the coupling of membrane potential to cellular metabolic status. Two K(ATP) channel subtypes coexist in the myocardium with one subtype located in the sarcolemma membrane and the other in the inner membrane of the mitochondria. The ATP-sensitive potassium channels can be pharmacologically modulated by a family
James D, McCully, Sidney, Levitsky
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Modulation of ischemia by regulation of the ATP-sensitive potassium channel

Cardiovascular Drugs and Therapy, 1993
During acute myocardial ischemia, passage of potassium ions across the sarcolemma to the extracellular space is a well-established phenomenon. A recent hypothesis is that the ATP-dependent potassium channel plays a role in contributing to the potassium loss.
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