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ATP-Sensitive Potassium Channels in Health and Disease
2010The ATP-sensitive potassium (K(ATP)) channel plays a crucial role in insulin secretion and thus glucose homeostasis. K(ATP) channel activity in the pancreatic beta-cell is finely balanced; increased activity prevents insulin secretion, whereas reduced activity stimulates insulin release. The beta-cell metabolism tightly regulates K(ATP) channel gating,
Proks, P, Clarke, R
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ATP-Sensitive Potassium Channels
Journal of Cardiovascular Pharmacology, 1994ATP-sensitive potassium channels are found in a number of different tissues where they undertake distinct physiologic functions. In endocrine cells they regulate the secretion of hormones such as insulin, prolactin, and growth hormone. They influence the excitability of cardiac, skeletal, and vascular smooth muscle.
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ATP-sensitive potassium channels in physiology, pathophysiology, and pharmacology
Current Opinion in Nephrology and Hypertension, 1992Potassium-selective ion channels, whose activity is inhibited by micromolar to millimolar concentrations of ATP presented at the cytoplasmic ATP-sensitive K+ (K+[ATP]) surface, have been found in a variety of cell types. These "K+(ATP) channels" have emerged as significant targets for physiologic as well as pharmacologic modulation of cell processes ...
S, Misler, G, Giebisch
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Amiodarone Inhibits Cardiac ATP‐Sensitive Potassium Channels
Journal of Cardiovascular Electrophysiology, 2000Amiodarone Inhibition of Cardiac KATPChannels.Introdttction:ATP‐sensitive K+channels (KATP) are expressed abundantly in cardiovascular tissues. Blocking this channel in experinuntal models of ischemia can reduce arrhythmias. We investigated the acute effects of amiodarone on the activity of cardiac sarcolemmal KATPchannels and their sensitivity to ATP ...
D S, Holmes +6 more
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ATP-sensitive potassium channels are not expressed in brain microvessels
Brain Research, 1993We used [3H]glibenclamide binding to assess ATP-sensitive K+ channels in isolated cerebral microvessels and in the cerebral cortex of the rat. We found no measurable specific glibenclamide binding in cerebral microvessels despite its abundance in cerebral cortical membranes, implying that ATP-sensitive K+ channels are not present in cerebral ...
H C, Sullivan, S I, Harik
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ATP‐Sensitive Potassium Channels and Their Physiological and Pathophysiological Roles
Comprehensive Physiology, 2018ABSTRACT ATP sensitive potassium channels (K ATP ) are so named because they open as cellular ATP levels fall. This leads to membrane hyperpolarization and thus links cellular metabolism to membrane excitability.
Tinker, A, Aziz, Q, Li, Y, Specterman, M
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ATP-sensitive potassium channels and myocardial preconditioning
Basic Research in Cardiology, 1995The ATP-sensitive potassium channel (KATP) has been shown to serve an endogenous cardioprotective role in a number of experimental models of myocardial stunning and infarction. More importantly, a majority of evidence has also been obtained which suggests that the KATP channel may be intimately involved in both triggering and maintaining the ...
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Involvement of ATP-sensitive potassium channels in preconditioning protection
Basic Research in Cardiology, 1994Single or multiple brief periods of ischemia (preconditioning, PC) have been shown to protect the myocardium from infarction during a subsequent more prolonged ischemic insult. To test the hypothesis that opening of ATP-sensitive potassium channels (KATP) is involved in this mechanism, either bimakalim, a KATP channel opener, or glibenclamide, a KATP ...
S, Rohmann +5 more
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Dual regulation of the ATP-sensitive potassium channel by caffeine
American Journal of Physiology-Cell Physiology, 2007ATP-sensitive potassium (KATP) channels couple cellular metabolic status to changes in membrane electrical properties. Caffeine (1,2,7-trimethylxanthine) has been shown to inhibit several ion channels; however, how caffeine regulates KATPchannels was not well understood.
Xia, Mao, Yongping, Chai, Yu-Fung, Lin
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ATP-Sensitive Potassium Channel Modulators and Cardiac Arrhythmias: An Update [PDF]
Current Pharmaceutical Design, 2014 Ischemia and heart failure-related cardiac arrhythmias, both atrial (e.g., atrial fibrillation) and ventricular (e.g., malignant tachyarrhythmias) represent a leading cause of morbidity and mortality worldwide. Despite the progress made in the last decade in understanding their pathophysiological mechanisms there is still an unmet need for safer and ...
Muntean, Danina +3 more
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