Results 251 to 260 of about 53,716 (302)

Review of the clinical electrooculogram - Part 1: Mechanism of the Light-Rise. [PDF]

Doc Ophthalmol
Constable PA, Loh L, Habjan MŠ, Padhy SK.   +3 more
europepmc   +1 more source

MitoQ Triggers Mitochondrial Collapse and Apoptotic Death in Glioblastoma Associated with KATP Channel Expression Changes. [PDF]

Neurochem Res
Karaaslan A, Hacioglu C.
europepmc   +1 more source

Preclinical Evaluation of Safety and Efficacy of QLS-111: A Novel Formulation of an Adenosine Triphosphate-Sensitive Potassium Channel Opener. [PDF]

Ophthalmol Sci
Wirostko BM, Roy Chowdhury U, Brandano LA, Casale RA, DeWalt DJ, Rykard LR, Htoo TM, Fautsch MP.   +7 more
europepmc   +1 more source

An Interesting Case of Sulphonylurea-Responsive Permanent Neonatal Diabetes Mellitus With Potassium Channel Mutation. [PDF]

Cureus
O'Connell K, Nadernejad C, Bupp C, Dewoolkar A.   +3 more
europepmc   +1 more source

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The Pharmacology of ATP-Sensitive Potassium Channels

Annual Review of Pharmacology and Toxicology, 1993
A potassium (K) channel that was inhibited by physiological (f1M) concen­ trations of intracellular ATP ([ATP]i) and that opened as [ATP]i decreased was first described in the heart ( l). Subsequently, similar K -channels all with unitary conductances in the range of 40-80 pS (measured under symmetrical high K+ conditions) were also found to exist in ...
G, Edwards, A H, Weston
openaire   +3 more sources

ATP-Sensitive Potassium Channels

Current Pharmaceutical Design, 2005
ATP-sensitive potassium (K(ATP)) channels link membrane excitability to metabolism. They are regulated by intracellular nucleotides and by other factors including membrane phospholipids, protein kinases and phosphatases. K(ATP) channels comprise octamers of four Kir6 pore-forming subunits associated with four sulphonylurea receptor subunits.
Rodrigo, GC, Standen, NB
openaire   +3 more sources

The Emerging Structural Pharmacology of ATP-Sensitive Potassium Channels

Molecular Pharmacology, 2022
ATP-sensitive potassium channels (KATP) are energy sensors that participate in a range of physiologic processes. These channels are also clinically validated drug targets. For decades, KATP inhibitors have been prescribed for diabetes and KATP activators have been used for the treatment of hypoglycemia, hypertension, and hair loss.
Jing-Xiang Wu, Dian Ding, Lei Chen
openaire   +2 more sources

Regulation of the ATP-Sensitive Potassium Channel

1990
A new class of K+ channels that link membrane potential to the bioenergetic situation of the cell has recently been discovered. These K+ channels (KATP) are normally closed at physiological intracellular ATP concentrations and open upon a diminution of [ATP]in.
J R, de Weille, M, Lazdunski
openaire   +2 more sources