Results 251 to 260 of about 3,142,470 (292)
Some of the next articles are maybe not open access.
ATP-Sensitive Potassium Channels in Health and Disease
2010The ATP-sensitive potassium (K(ATP)) channel plays a crucial role in insulin secretion and thus glucose homeostasis. K(ATP) channel activity in the pancreatic beta-cell is finely balanced; increased activity prevents insulin secretion, whereas reduced activity stimulates insulin release. The beta-cell metabolism tightly regulates K(ATP) channel gating,
Proks, P, Clarke, R
openaire +3 more sources
ATP-Sensitive Potassium Channels
Journal of Cardiovascular Pharmacology, 1994ATP-sensitive potassium channels are found in a number of different tissues where they undertake distinct physiologic functions. In endocrine cells they regulate the secretion of hormones such as insulin, prolactin, and growth hormone. They influence the excitability of cardiac, skeletal, and vascular smooth muscle.
openaire +2 more sources
ATP-sensitive potassium channels are not expressed in brain microvessels
Brain Research, 1993We used [3H]glibenclamide binding to assess ATP-sensitive K+ channels in isolated cerebral microvessels and in the cerebral cortex of the rat. We found no measurable specific glibenclamide binding in cerebral microvessels despite its abundance in cerebral cortical membranes, implying that ATP-sensitive K+ channels are not present in cerebral ...
H C, Sullivan, S I, Harik
openaire +2 more sources
ATP-sensitive potassium channels in cultured arterial segments
American Journal of Physiology-Heart and Circulatory Physiology, 1996Organ cultures of arteries have been used to study growth responses, proliferation, and contractility. However, the function of specific-ion channels in cultured arteries has not been investigated. ATP-sensitive K+ (KATP) channels play an important role in the control of arterial tone.
Kleppisch, Thomas +2 more
openaire +3 more sources
ATP-Sensitive Potassium Channels: A Review of their Cardioprotective Pharmacology
Journal of Molecular and Cellular Cardiology, 2000ATP-sensitive potassium channels (K(ATP)) have been thought to be a mediator of cardioprotection for the last ten years. Significant progress has been made in learning the pharmacology of this channel as well as its molecular regulation with regard to cardioprotection.
G J, Grover, K D, Garlid
openaire +2 more sources
Dual regulation of the ATP-sensitive potassium channel by caffeine
American Journal of Physiology-Cell Physiology, 2007ATP-sensitive potassium (KATP) channels couple cellular metabolic status to changes in membrane electrical properties. Caffeine (1,2,7-trimethylxanthine) has been shown to inhibit several ion channels; however, how caffeine regulates KATPchannels was not well understood.
Xia, Mao, Yongping, Chai, Yu-Fung, Lin
openaire +2 more sources
ATP‐Sensitive Potassium Channels and Their Physiological and Pathophysiological Roles
Comprehensive Physiology, 2018ABSTRACT ATP sensitive potassium channels (K ATP ) are so named because they open as cellular ATP levels fall. This leads to membrane hyperpolarization and thus links cellular metabolism to membrane excitability.
Tinker, A, Aziz, Q, Li, Y, Specterman, M
openaire +3 more sources
ATP-Sensitive Potassium Channel Modulators and Cardiac Arrhythmias: An Update [PDF]
Current Pharmaceutical Design, 2014 Ischemia and heart failure-related cardiac arrhythmias, both atrial (e.g., atrial fibrillation) and ventricular (e.g., malignant tachyarrhythmias) represent a leading cause of morbidity and mortality worldwide. Despite the progress made in the last decade in understanding their pathophysiological mechanisms there is still an unmet need for safer and ...
Muntean, Danina +3 more
openaire +3 more sources
ATP-sensitive potassium channels and myocardial preconditioning
Basic Research in Cardiology, 1995The ATP-sensitive potassium channel (KATP) has been shown to serve an endogenous cardioprotective role in a number of experimental models of myocardial stunning and infarction. More importantly, a majority of evidence has also been obtained which suggests that the KATP channel may be intimately involved in both triggering and maintaining the ...
openaire +2 more sources
Trafficking of ATP-sensitive potassium channels in health and disease
Biochemical Society Transactions, 2007KATP channels (ATP-sensitive potassium channels), comprising four subunits each of Kir6.2 (inwardly rectifying potassium channel 6.2) and the SUR1 (sulfonylurea receptor 1), play a central role in glucose-stimulated insulin secretion by the pancreatic β-cell.
Sivaprasadarao, A. +3 more
openaire +2 more sources