Results 271 to 280 of about 53,716 (302)

Trafficking of ATP-sensitive potassium channels in health and disease

Biochemical Society Transactions, 2007
KATP channels (ATP-sensitive potassium channels), comprising four subunits each of Kir6.2 (inwardly rectifying potassium channel 6.2) and the SUR1 (sulfonylurea receptor 1), play a central role in glucose-stimulated insulin secretion by the pancreatic β-cell.
Sivaprasadarao, A., Taneja, T. K., Mankouri, J., Smith, A. J.   +3 more
openaire   +2 more sources

ATP-SENSITIVE POTASSIUM CHANNELS: A Model of Heteromultimeric Potassium Channel/Receptor Assemblies

Annual Review of Physiology, 1999
▪ Abstract  ATP-sensitive K+ channels (KATP channels) play important roles in many cellular functions by coupling cell metabolism to electrical activity. By cloning members of the novel inwardly rectifying K+ channel subfamily Kir6.0 (Kir6.1 and Kir6.2) and the receptors for sulfonylureas (SUR1 and SUR2), researchers have clarified the molecular ...
openaire   +2 more sources

Mitochondrial ATP-sensitive potassium channels in surgical cardioprotection

Archives of Biochemistry and Biophysics, 2003
ATP-sensitive potassium channels allow for the coupling of membrane potential to cellular metabolic status. Two K(ATP) channel subtypes coexist in the myocardium with one subtype located in the sarcolemma membrane and the other in the inner membrane of the mitochondria. The ATP-sensitive potassium channels can be pharmacologically modulated by a family
James D, McCully, Sidney, Levitsky
openaire   +2 more sources

ATP-Sensitive Potassium Channels: A Review of their Cardioprotective Pharmacology

Journal of Molecular and Cellular Cardiology, 2000
ATP-sensitive potassium channels (K(ATP)) have been thought to be a mediator of cardioprotection for the last ten years. Significant progress has been made in learning the pharmacology of this channel as well as its molecular regulation with regard to cardioprotection.
G J, Grover, K D, Garlid
openaire   +2 more sources

ATP-sensitive potassium channels in cultured arterial segments

American Journal of Physiology-Heart and Circulatory Physiology, 1996
Organ cultures of arteries have been used to study growth responses, proliferation, and contractility. However, the function of specific-ion channels in cultured arteries has not been investigated. ATP-sensitive K+ (KATP) channels play an important role in the control of arterial tone.
Kleppisch, Thomas, Winter, Barbara, Nelson, Mark T.; id_orcid 0000-0002-6608-8784   +2 more
openaire   +3 more sources

ATP-sensitive potassium channels: metabolic sensing and cardioprotection

Journal of Applied Physiology, 2007
The cardiovascular system operates under a wide scale of demands, ranging from conditions of rest to extreme stress. How the heart muscle matches rates of ATP production with utilization is an area of active investigation. ATP-sensitive potassium (KATP) channels serve a critical role in the orchestration of myocardial energetic well-being.
L V, Zingman, A E, Alekseev, D M, Hodgson-Zingman, A, Terzic   +3 more
openaire   +2 more sources

Blockade of Myocardial ATP-sensitive Potassium Channels by Ketamine 

Anesthesiology, 1997
Background The adenosine triphosphate (ATP)-sensitive potassium (KATP) channel underlies the increase in potassium permeability during hypoxia and ischemia. The increased outward potassium current during ischemia may be an endogenous cardioprotective mechanism.
S H, Ko, S K, Lee, Y J, Han, H, Choe, Y G, Kwak, S W, Chae, K P, Cho, H S, Song   +7 more
openaire   +2 more sources

The Role of ATP Sensitive Potassium Channels in Myocardial Protection

Journal of Cardiac Surgery, 1995
Several factors have pointed to a potential link between ATP sensitive potassium channel activation in ventricular myocytes and the phenomenon of myocardial preconditioning. Preconditioning can be blocked by adenosine antagonists, and is mimicked by adenosine A1-receptor agonists.
B A, Cason, H J, Gordon, E G, Avery, R F, Hickey   +3 more
openaire   +2 more sources

Role of ATP-sensitive potassium channels in the basilar artery

American Journal of Physiology-Heart and Circulatory Physiology, 1993
This study examined the hypothesis that activation of ATP-sensitive potassium channels produces vasodilation and contributes to dilator responses of the basilar artery to acetylcholine in vivo. Diameter of the basilar artery (baseline diam = 245 +/- 14 microns, means +/- SE) was measured through a cranial window in anesthetized rats. RP52891 (1 microM)
F M, Faraci, D D, Heistad
openaire   +2 more sources

Modulation of ischemia by regulation of the ATP-sensitive potassium channel

Cardiovascular Drugs and Therapy, 1993
During acute myocardial ischemia, passage of potassium ions across the sarcolemma to the extracellular space is a well-established phenomenon. A recent hypothesis is that the ATP-dependent potassium channel plays a role in contributing to the potassium loss.
openaire   +2 more sources