Results 21 to 30 of about 1,767,276 (258)
Expression and function of ATP-dependent potassium channels in zebrafish islet β-cells [PDF]
, 2017 ATP-sensitive potassium channels (K(ATP) channels) are critical nutrient sensors in many mammalian tissues. In the pancreas, K(ATP) channels are essential for coupling glucose metabolism to insulin secretion.
Conway, Hannah +8 more
core +2 more sources
Extracellular ATP: A Feasible Target for Cancer Therapy
Cells, 2020 Adenosine triphosphate (ATP) is one of the main biochemical components of the tumor microenvironment (TME), where it can promote tumor progression or tumor suppression depending on its concentration and on the specific ecto-nucleotidases and receptors ...
Valentina Vultaggio-Poma +2 more
semanticscholar +1 more source
Electron Transfer Precedes ATP Hydrolysis during Nitrogenase Catalysis [PDF]
, 2013 The biological reduction of N2 to NH3 catalyzed by Mo-dependent nitrogenase requires at least eight rounds of a complex cycle of events associated with ATP-driven electron transfer (ET) from the Fe protein to the catalytic MoFe protein, with each ET ...
Antony, Edwin +7 more
core +2 more sources
Thermodynamics of the ATPase Cycle of GlcV, the Nucleotide-Binding Domain of the Glucose ABC Transporter of Sulfolobus solfataricus [PDF]
, 2006 ATP-binding cassette transporters drive the transport of substrates across the membrane by the hydrolysis of ATP. They typically have a conserved domain structure with two membrane-spanning domains that form the transport channel and two cytosolic ...
Albers, Sonja-Verena, +5 more
core +4 more sources
Nature Communications, 2018 Protein aggregation causes α-synuclein to switch from its physiological role to a pathological toxic gain of function. Under physiological conditions, monomeric α-synuclein improves ATP synthase efficiency.
M. H. Ludtmann +22 more
semanticscholar +1 more source
Further Characterization of Dopamine Release by Permeabilized PC 12 Cells [PDF]
, 1987 Rat pheochromocytoma cells (PC 12) permeabilized with staphylococcal α-toxin release [3H]dopamine after addition of micromolar Ca2+. This does not require additional Mg2+-ATP (in contrast to bovine adrenal medullary chromaffin cells).
Ahnert-Hilger G. +18 more
core +1 more source
The T790M mutation in EGFR kinase causes drug resistance by increasing the affinity for ATP
Proceedings of the National Academy of Sciences of the United States of America, 2008 Lung cancers caused by activating mutations in the epidermal growth factor receptor (EGFR) are initially responsive to small molecule tyrosine kinase inhibitors (TKIs), but the efficacy of these agents is often limited because of the emergence of drug ...
C. Yun +7 more
semanticscholar +1 more source
Journal of Oral Microbiology, 2019 Acetyl phosphate (AcP) is generally produced from acetyl coenzyme A by phosphotransacetylase (Pta), and subsequent reaction with ADP, catalyzed by acetate kinase (Ack), produces ATP.
Yasuo Yoshida +4 more
doaj +1 more source
Reinforcement Learning for Guiding the E Theorem Prover
Proceedings of the International Florida Artificial Intelligence Research Society Conference, 2023 Automated Theorem Proving (ATP) systems search for a proof in a rapidly growing space of possibilities. Heuristics have a profound impact on search, and ATP systems make heavy use of heuristics.
Jack McKeown, Geoff Sutcliffe
doaj +1 more source
The Role of Heat Shock Protein 70 kDa in Asthma
Journal of Asthma and Allergy, 2021 Marina Shevchenko,1 Ekaterina Servuli,1,2 Zarema Albakova,1,3 Leonid Kanevskiy,1 Alexander Sapozhnikov1,3 1Department of Immunology, Shemyakin and Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences, Moscow, Russia; 2Department of ...
Shevchenko M +4 more
doaj