Results 31 to 40 of about 1,767,276 (258)

Changes in contractile characteristics of rat skeletal muscles associated with P2-receptor activation after spinal cord transection [PDF]

open access: yesАнналы клинической и экспериментальной неврологии
Introduction. Traumatic spinal cord and peripheral-nerve injury is associated with release of proinflammatory cytokines and chemokines, which may stimulate neuronal activity.
Adel E. Khairullin   +6 more
doaj   +1 more source

Taking over Cellular Energy-Metabolism for TBSV Replication: The High ATP Requirement of an RNA Virus within the Viral Replication Organelle

open access: yesViruses, 2020
Recent discoveries on virus-driven hijacking and compartmentalization of the cellular glycolytic and fermentation pathways to support robust virus replication put the spotlight on the energy requirement of viral processes.
Peter D. Nagy, Wenwu Lin
doaj   +1 more source

Seismic Upgrading of the Heritage-Protected Reinforced Concrete Warehouse in Rijeka, Croatia

open access: yesBuildings
Despite Croatia experiencing two strong earthquakes in 2020, Rijeka was not directly affected, underscoring the importance of proactive seismic assessment and strengthening in all seismic regions.
Berislav Bošnjak   +2 more
doaj   +1 more source

Evolution of uncontrolled proliferation and the angiogenic switch in cancer

open access: yesMathematical Biosciences and Engineering, 2012
The major goal of evolutionary oncology is to explain how malignant traits evolve to become cancer 'hallmarks.' One such hallmark---the angiogenic switch---is difficult to explain for the same reason altruism is difficult to explain. An angiogenic clone
John D. Nagy, Dieter Armbruster
doaj   +1 more source

Selective recognition of ATP by multivalent nano-assemblies of bisimidazolium amphiphiles through “turn-on” fluorescence response

open access: yesBeilstein Journal of Organic Chemistry, 2020
Bisimidazolium receptors, tagged with chromophoric pyrene at one end and linked to an n-alkyl chain at the other, underwent self-assembly in aqueous media depending on the length of the alkyl segment.
Rakesh Biswas   +3 more
doaj   +1 more source

Colostrum fails to prevent bovine/camelid neonatal neutrophil damage from AFB1

open access: yesJournal of Immunotoxicology, 2020
Exposure to environmental toxicants that affect the immune system and overall health of many mammals is mostly unavoidable. One of the more common substances is the mycotoxins, especially carcinogenic aflatoxin (AF)B1 which also causes immune suppression/
Sajad Najafi   +4 more
doaj   +1 more source

Association of leukocyte mitochondrial DNA copy number with longitudinal C-reactive protein levels and survival in older adults: a cohort study

open access: yesImmunity & Ageing, 2022
Background Systemic chronic inflammation occurs with age. The association of the leukocyte mitochondrial DNA copy number, a measure of mitochondrial function in aging, with the temporal profile of serum high-sensitivity C-reactive protein and mortality ...
I-Chien Wu   +9 more
doaj   +1 more source

Methylene Blue Treatment Enhances Mitochondrial Function and Locomotor Activity in a C57BL/6 Mouse Model of Multiple Sclerosis [PDF]

open access: yesTrends in Pharmaceutical Sciences, 2020
Multiple sclerosis (MS) is a neurodegenerative disease. Although multiple factors are involved in the pathogenesis of MS, there are several lines of evidence that oxidative stress and mitochondrial dysfunction are involved in neuronal demyelination and ...
Mohammad Mehdi Ommati   +5 more
doaj   +1 more source

Extracellular ATP drives systemic inflammation, tissue damage and mortality [PDF]

open access: yes, 2014
Systemic inflammatory response syndromes (SIRS) may be caused by both infectious and sterile insults, such as trauma, ischemia-reperfusion or burns. They are characterized by early excessive inflammatory cytokine production and the endogenous release of ...
Brouckaert, Peter   +4 more
core   +1 more source

A Systematic Review of the Expression, Signalling and Function of P2 Receptors in Primary Bone Cancer

open access: yesFrontiers in Bioscience-Landmark, 2022
Primary bone cancers are rare malignant diseases with significant morbidity and mortality. The treatment regimen relies on a combination of surgery (often involving amputation), chemotherapy and radiotherapy with outcomes dependent on localization of the
Luke Tattersall   +5 more
doaj   +1 more source

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