Results 31 to 40 of about 1,508,022 (243)
Evolution of uncontrolled proliferation and the angiogenic switch in cancer
Mathematical Biosciences and Engineering, 2012 The major goal of evolutionary oncology is to explain how malignant traits evolve to become cancer 'hallmarks.' One such hallmark---the angiogenic switch---is difficult to explain for the same reason altruism is difficult to explain. An angiogenic clone
John D. Nagy, Dieter Armbruster
doaj +1 more source
Beilstein Journal of Organic Chemistry, 2020 Bisimidazolium receptors, tagged with chromophoric pyrene at one end and linked to an n-alkyl chain at the other, underwent self-assembly in aqueous media depending on the length of the alkyl segment.
Rakesh Biswas +3 more
doaj +1 more source
Colostrum fails to prevent bovine/camelid neonatal neutrophil damage from AFB1
Journal of Immunotoxicology, 2020 Exposure to environmental toxicants that affect the immune system and overall health of many mammals is mostly unavoidable. One of the more common substances is the mycotoxins, especially carcinogenic aflatoxin (AF)B1 which also causes immune suppression/
Sajad Najafi +4 more
doaj +1 more source
Principal factors that determine the extension of detection range in molecular beacon aptamer/conjugated polyelectrolyte bioassays. [PDF]
, 2015 A strategy to extend the detection range of weakly-binding targets is reported that takes advantage of fluorescence resonance energy transfer (FRET)-based bioassays based on molecular beacon aptamers (MBAs) and cationic conjugated polyelectrolytes (CPEs).
Bazan, Guillermo C +5 more
core +1 more source
Frontiers in Bioscience-Landmark, 2022 Fatty acid metabolism has attracted extensive attention for its key role in the occurrence and development of tumors. Fatty acids not only participate in the biosynthesis of phospholipids in the membrane to overcome the demand for rapidly proliferating ...
Hongdan Chen +5 more
doaj +1 more source
A new type of Na+-driven ATP synthase membrane rotor with a two-carboxylate ion-coupling motif [PDF]
, 2013 : The anaerobic bacterium Fusobacterium nucleatum uses glutamate decarboxylation to generate a transmembrane gradient of Na+. Here, we demonstrate that this ion-motive force is directly coupled to ATP synthesis, via an F1Fo-ATP synthase with a novel Na ...
Faraldo-Gómez, José D. +8 more
core +3 more sources
Expression and function of ATP-dependent potassium channels in zebrafish islet β-cells [PDF]
, 2017 ATP-sensitive potassium channels (K(ATP) channels) are critical nutrient sensors in many mammalian tissues. In the pancreas, K(ATP) channels are essential for coupling glucose metabolism to insulin secretion.
Conway, Hannah +8 more
core +2 more sources
Biomaterial design strategies for enhancing mitochondrial transplantation therapy
BMEMat, EarlyView.Biomaterials to facilitate mitochondrial transplantation therapy: biomaterials as barriers to protect mitochondria from pathophysiological microenvironments, like osmotic stress caused by the excessive concentration of calcium ion, reactive oxygen species, and advanced glycation end products; biomaterials integrating with biochemical cues to improve ...
Shaoyang Kang +12 more
wiley +1 more source
CellsThe intranasal delivery of exogenous mitochondria is a potential therapy for Parkinson’s disease (PD). The regulatory mechanisms and effectiveness in genetic models remains uncertain, as well as the impact of modulating the mitochondrial permeability ...
Jui-Chih Chang +7 more
doaj +1 more source
ATP-dependent chromatosome remodeling [PDF]
, 2008 Chromatin serves to package, protect and organize the complex eukaryotic genomes to assure their stable inheritance over many cell generations. At the same time, chromatin must be dynamic to allow continued use of DNA during a cell's lifetime.
Dimitrov S. +6 more
core +1 more source