Results 41 to 50 of about 9,465 (268)
Copper induce zebrafish retinal developmental defects via triggering stresses and apoptosis
Cell Communication and Signaling, 2020 Background The disorder of copper homeostasis is linked with disease and developmental defects, and excess copper_nanoparticles (CuNPs) and ion (Cu2+) will induce developmental malformation and disease in organisms. However, little knowledge is available
Guang Zhao +3 more
doaj +1 more source
Computational and Structural Biotechnology Journal, 2020 ATP7A is a critical copper transporter involved in Menkes Disease, Occipital horn Syndrome and X-linked distal spinal muscular atrophy type 3 which are X linked genetic disorders. These are rare diseases and their genetic epidemiology of the diseases is unknown.
Aditi Mhaske +7 more
openaire +3 more sources
Transcriptional regulation of copper metabolism genes in the liver of fetal and neonatal control and iron-deficient rats [PDF]
, 2014 Acknowledgments The authors’ work is supported by Scottish Government (Rural and Environmental Scientific and Analytical Services). We are grateful to Ms Val Stevens for analytical and technical assistance and to the Biological Resource Facility staff ...
Hayes, Helen +3 more
core +2 more sources
Frontiers in Oncology, 2022 Chemotherapy resistance represents a formidable obstacle in advanced or metastatic colorectal cancer (CRC) patients. It is reported that ATPase copper transporting alpha (ATP7A) plays an important role in chemotherapy resistance in CRC.
Yue Zhou +17 more
doaj +1 more source
ATP7A (Menkes protein) functions in axonal targeting and synaptogenesis [PDF]
Molecular and Cellular Neuroscience, 2007 Menkes disease (MD) is a neurodegenerative disorder caused by mutations in the copper transporter, ATP7A, a P-type ATPase. We previously used the olfactory system to demonstrate that ATP7A expression is developmentally, not constitutive, regulated, peaking during synaptogenesis when it is highly expressed in extending axons in a copper-independent ...
Rajaâ, El Meskini +5 more
openaire +2 more sources
The effect of maternal iron deficiency on zinc and copper levels and on genes of zinc and copper metabolism during pregnancy in the rat [PDF]
, 2019 Fe deficiency is relatively common in pregnancy and has both short- and long-term consequences. However, little is known about the effect on the metabolism of other micronutrients.
Cottin, Sarah C. +5 more
core +5 more sources
Journal of Cell Science, 2023 The homologous P-type copper-ATPases (Cu-ATPases) ATP7A and ATP7B are the key regulators of copper homeostasis in mammalian cells. In polarized epithelia, upon copper treatment, ATP7A and ATP7B traffic from the trans-Golgi network (TGN) to basolateral ...
Ruturaj +6 more
semanticscholar +1 more source
eLife, 2017 Genetic and environmental factors, such as metals, interact to determine neurological traits. We reasoned that interactomes of molecules handling metals in neurons should include novel metal homeostasis pathways.
Heather S Comstra +14 more
doaj +1 more source
Carboplatin/taxane-induced gastrointestinal toxicity: a pharmacogenomics study on the SCOTROC1 trial [PDF]
, 2016 Carboplatin/taxane combination is first-line therapy for ovarian cancer. However, patients can encounter treatment delays, impaired quality of life, even death because of chemotherapy-induced gastrointestinal (GI) toxicity.
Brown, R. +7 more
core +1 more source
Journal of Inherited Metabolic Disease, 2023 In patients with ATP7A‐related disorders, counseling is challenging due to clinical overlap between the entities, the absence of predictive biomarkers and a clear genotype‐phenotype correlation. We performed a systematic literature review by querying the
S. De Feyter, A. Beyens, B. Callewaert
semanticscholar +1 more source