Expression of miRNAs Targeting ATP Binding Cassette Transporter 1 (ABCA1) among Patients with Significant Carotid Artery Stenosis [PDF]
Biomedicines, 2021 Background: Carotid artery stenosis is a dynamic process associated with an increased risk of cardiovascular events. However, knowledge of biomarkers useful for identifying and quantifying high-risk carotid plaques associated with the increased incidence
Seonjeong Jeong +5 more
doaj +5 more sources
ATP-binding cassette transporter 1 attenuates ovalbumin-induced neutrophilic airway inflammation. [PDF]
Am J Respir Cell Mol Biol, 2014 Apolipoprotein A-I (apoA-I) is an important component of high-density lipoprotein particles that mediates reverse cholesterol transport out of cells by interacting with the ATP-binding cassette transporter 1 (ABCA1). apoA-I has also been shown to attenuate neutrophilic airway inflammation in experimental ovalbumin (OVA)-induced asthma by reducing the ...
Dai C +13 more
europepmc +6 more sources
Corticotropin-Releasing Hormone (CRH) Promotes Macrophage Foam Cell Formation via Reduced Expression of ATP Binding Cassette Transporter-1 (ABCA1). [PDF]
PLoS ONE, 2015 Atherosclerosis, the major pathology of cardiovascular disease, is caused by multiple factors involving psychological stress. Corticotropin-releasing hormone (CRH), which is released by neurosecretory cells in the hypothalamus, peripheral nerve terminals
Wonkyoung Cho +2 more
doaj +6 more sources
The ATP-binding cassette transporter 1 mediates lipid efflux from Sertoli cells and influences male fertility [PDF]
Journal of Lipid Research, 2004 The liver X receptor/retinoid X receptor (LXR/RXR)-regulated gene ABCA1 effluxes cellular cholesterol and phospholipid to apolipoprotein A1 (apoA1), which is the rate-limiting step in high-density lipoprotein synthesis.
David M. Selva +9 more
doaj +3 more sources
D-helix influences dimerization of the ATP-binding cassette (ABC) transporter associated with antigen processing 1 (TAP1) nucleotide-binding domain. [PDF]
PLoS ONE, 2017 ATP-binding cassette (ABC) transporters form a large family of transmembrane importers and exporters. Using two nucleotide-binding domains (NBDs), which form a canonical ATP-sandwich dimer at some point within the transport cycle, the transporters ...
Ahmet S Vakkasoglu +2 more
doaj +5 more sources
DeepRTCP: Predicting ATP-Binding Cassette Transporters Based on 1-Dimensional Convolutional Network [PDF]
Frontiers in Cell and Developmental Biology, 2021 ATP-binding cassette (ABC) transporters can promote cells to absorb nutrients and excrete harmful substances. It plays a vital role in the transmembrane transport of macromolecules. Therefore, the identification of ABC transporters is of great significance for the biological research. This paper will introduce a novel method called DeepRTCP.
Zhaoxi Zhang +3 more
openaire +3 more sources
ANALYSIS OF THE FAMILY OF A PATIENT WITH X-LINKED ADRENOLEUKODYSTROPHY AND LITERATURE REVIEW [PDF]
精准医学杂志, 2023 Objective To analyze the mutation site in the ATP-binding cassette subfamily D member 1 gene (ABCD1) in the family of a patient with X-linked adrenoleukodystrophy (X-ALD), and to explore the diagnosis, treatment, and prognosis of X-ALD based on the ...
JIANG Jing, JIN Yang, WU Yujiao, LIU Xuewu
doaj +1 more source
Stem Cell Research, 2021 ATP-binding cassette transporter subfamily D member 1 (ABCD1) gene is a member of ABC transporter super family, which conduct peroxisomal import of very long chain fatty acid and crucial underlying factor that induces X-linked adrenoleukodystrophy (X-ALD)
Wonjun Hong +5 more
doaj +1 more source
Asymmetric Conformational Flexibility in the ATP-Binding Cassette Transporter HI1470/1 [PDF]
Biophysical Journal, 2009 Putative metal-chelate-type ABC transporter HI1470/1 is homologous with vitamin B(12) importer BtuCD but exhibits a distinct inward-facing conformation in contrast to the outward-facing conformation of BtuCD. Normal-mode analysis of HI1470/1 reveals the intrinsic asymmetric conformational flexibility in this transporter and demonstrates that the ...
Weng, Jingwei +3 more
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Increased protein expression of ABCA1, HMG-CoA reductase, and CYP46A1 induced by garlic and allicin in the brain mouse and astrocytes-isolated from C57BL/6J [PDF]
Avicenna Journal of Phytomedicine, 2021 Objective: Regulation of cholesterol level is essential for the brain optimal function. The beneficial effect of garlic consumption on cholesterol homeostasis is well known; however, the molecular mechanism to support its properties is unclear.
Zahra Nazeri +4 more
doaj +1 more source