Results 121 to 130 of about 40,880 (280)
Journal of Biological Chemistry, 2003 We have mapped the domains of lipid-free apoA-I that promote cAMP-dependent and cAMP-independent cholesterol and phospholipid efflux. The cAMP-dependent lipid efflux in J774 mouse macrophages was decreased by ∼80–92% by apoA-I[Δ(185–243)], only by 15% by
A. Chroni +6 more
semanticscholar +1 more source
Redox control of multidrug resistance and Its possible modulation by antioxidants [PDF]
, 2016 Clinical efficacy of anticancer chemotherapies is dramatically hampered by multidrug resistance (MDR) dependent on inherited traits, acquired defence against toxins, and adaptive mechanisms mounting in tumours.
Cort, A. +4 more
core +3 more sources
Advanced Science, Volume 13, Issue 5, 27 January 2026.Impaired anti‐tumor immunity is mediated by TREM2 + macrophages in non‐small cell lung cancer. TREM2 + macrophages prevent anti‐tumor immunity depending on the limitation of CD4 + T and NK cells. TREM2 promotes cholesterol efflux via ABCA1 to limit the production of CX3CL1 in macrophages.
Yunhan Wang +9 more
wiley +1 more source
Transcriptional regulation of ATP-binding cassette transporter A1 expression by a novel signaling pathway. [PDF]
J Biol Chem, 2011 ATP-binding cassette transporter A1 (ABCA1) is a membrane-bound protein that regulates the efflux of cholesterol derived from internalized lipoproteins. Using a mouse macrophage cell line, this report studied the impact of low-density lipoproteins (LDL) on ABCA1 expression and the signaling pathway responsible for lipoprotein-induced ABCA1 expression ...
Chen X +5 more
europepmc +4 more sources
A Chemical Genetic Approach To The Study Of Cellular Transport [PDF]
, 2005 The focus of this thesis is the use of chemical genetics to study two different aspects of membrane biology, (a) the mechanisms underlying cellular lipid transport and (b) the intersection between endocytic and exocytic traffic.
Nieland, T.J.F.
core +2 more sources
Biology of Cholangiocytes: From Bench to Bedside [PDF]
, 2016 Cholangiocytes, the lining epithelial cells in bile ducts, are an important subset of liver cells. They are activated by endogenous and exogenous stimuli and are involved in the modification of bile volume and composition.
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core +1 more source
Advanced Science, Volume 13, Issue 6, 30 January 2026.NAD⁺ homeostasis maintains neuronal integrity through opposing actions of NMNAT2 and SARM1. Loss of NMNAT2 in glutamatergic neurons reprograms cortical metabolism from glucose to lipid catabolism, depletes lipid stores, and triggers inflammation and neurodegeneration.
Zhen‐Xian Niou +9 more
wiley +1 more source
Intestinal cholesterol absorption is substantially reduced in mice deficient in both ABCA1 and ACAT2
Journal of Lipid Research, 2005 The process of cholesterol absorption has yet to be completely defined at the molecular level. Because of its ability to esterify cholesterol for packaging into nascent chylomicrons, ACAT2 plays an important role in cholesterol absorption.
Ryan E. Temel +7 more
doaj +1 more source
Expression pattern of the human ABC transporters in pluripotent embryonic stem cells and in their derivatives [PDF]
, 2014 Background: ATP-binding Cassette (ABC) transporters have key roles in various physiological functions as well as providing chemical defense and stress tolerance in human tissues.
Apáti, Ágota +10 more
core +1 more source
Flow Cytometry: Advances, Challenges and Trends
BioEssays, Volume 48, Issue 1, January 2026.Recent advances in flow cytometry span hardware, data processing, and AI‐driven analytics. Emerging modalitiesincluding spectral, imaging, mass, and nano/EV cytometryenable higher‐parameter and small‐particle detection. Integrated machine learning drives a shift from manual gating toward automated multi‐omics workflows.
J. Paul Robinson +2 more
wiley +1 more source