Results 91 to 100 of about 634,427 (259)

Reconstructing enzyme evolution by protein engineering

FEBS Letters, EarlyView.
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler, Markus R. Busch, Reinhard Sterner   +2 more
wiley   +1 more source

Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential

FEBS Letters, EarlyView.
Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta, Hari Baskar Balasubramanian, Amir Pasokh, Marietta Zille   +3 more
wiley   +1 more source

Epigenetic reprogramming of lineage switching in cancer

FEBS Letters, EarlyView.
Cancer cells rarely commit to a single identity. Epigenetic mechanisms and tumor microenvironment cues push epithelial cells toward flexible, hybrid states that can shift into mesenchymal, neuroendocrine, or stem‐like fates, driving metastasis, drug resistance, and tumor heterogeneity. Targeting the epigenetic regulators behind these transitions, using
Ezgi Boyvatlı, Burcu Akman, Ezgi Bağırsakçı, Nese Atabey, Serap Erkek‐Ozhan   +4 more
wiley   +1 more source

Attention Bias or the Attention Control Ability: Measuring the Role of Attention Bias as a Cause for Anxiety Vulnerability

Procedia - Social and Behavioral Sciences, 2013
AbstractTo our knowledge, at the moment there is no study to directly test the hypothesis of threatening information bias as a cause of anxiety, by means of using a control group. In the present study we propose the concomitant testing of two hypothesis regarding anxiety etiology: the threatening information bias hypothesis and the attention control ...
openaire   +1 more source

Effect of Cognitive Rehabilitation on Reduction of Attention Bias to Frightful Stimuli in Adolescents with Post-Traumatic Stress Disorder

طب جانباز, 2014
Aims: Post-traumatic stress disorder is one of the anxiety disorders which is occured in response to total panic in the disaster that threaten the life of the person.
T. Alsafi, V. Nejati, N.A. Sarhan, M. Maghsudloo   +3 more
doaj  

Sustained, not habituated, activity in the human amygdala: A pilot fMRI dot-probe study of attentional bias to fearful faces

Cogent Psychology, 2016
The human amygdala consciously and nonconsciously processes facial expressions and directs spatial attention to them. Research has shown that amygdala activity habituates after repeated exposure to emotionally salient stimuli during passive viewing tasks.
Millicent A. Weber, Kelly A. Morrow, Will S. Rizer, Keara J. Kangas, Joshua M. Carlson   +4 more
doaj   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Keratin 19 as a prognostic marker and contributing factor of metastasis and chemoresistance in high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch, Isabel Vogel, Sina Nokodian, Johanna Moeller, Antonia Blechschmidt, Vicky Hecht, Vanessa Kuentzel, Katharina Thiedig, Melissa Schwab, Oliver Schilling, Holger Bronger, Marion Kiechle, Viktor Magdolen, Tobias Dreyer   +13 more
wiley   +1 more source

Attentional bias alignment for pain: A neurophysiological approach

The Journal of Pain
Attentional bias (AB) toward pain-related information has been implicated in the development and maintenance of pain problems. Recent theoretical frameworks propose that AB is not a fixed trait but rather a dynamic process that aligns with contextual and goal-related factors.
Eleana A. Pinto, Justine Mac Goris, Stefaan Van Damme, Richard Benning, Dimitri ML Van Ryckeghem   +4 more
openaire   +4 more sources

Longitudinal circulating tumor DNA profiling in patients with advanced endometrial cancer using an off‐the‐shelf targeted NGS panel

Molecular Oncology, EarlyView.
Intratumour heterogeneity complicates precision management of advanced endometrial cancer. Circulating tumor DNA (ctDNA) offers a minimally invasive strategy to capture tumor evolution and therapeutic resistance. Here, we compare tumor‐agnostic NGS with tumor‐informed ddPCR, outlining their relative sensitivity, concordance, and clinical implications ...
Carlos Casas‐Arozamena, Karin Teien Lande, Eva Diaz, Ana Vilar, Juan Cueva, Efigenia Arias, Victoria Sampayo, Alicia Abalo, Nerea González, Eva Colás, Antonio Gil‐Moreno, Miguel Abal, Gema Moreno‐Bueno, Therese Sørlie, Kristina Lindemann, Laura Muinelo‐Romay   +15 more
wiley   +1 more source