Protective efficacy of centralized and polyvalent envelope immunogens in an attenuated equine lentivirus vaccine. [PDF]
PLoS Pathogens, 2015 Lentiviral Envelope (Env) antigenic variation and related immune evasion present major hurdles to effective vaccine development. Centralized Env immunogens that minimize the genetic distance between vaccine proteins and circulating viral isolates are an ...
Jodi K Craigo +6 more
doaj +20 more sources
Evaluation of a Newly Developed Live Attenuated Vaccine Candidate Against Lawsonia intracellularis [PDF]
VaccinesBackground/Objectives: Lawsonia intracellularis (L. intracellularis) is an important intestinal pathogen that causes porcine proliferative enteropathy (PPE) in swine production worldwide.
Huixing Lin +5 more
doaj +2 more sources
Cost-Effectiveness Analysis of Herpes Zoster Vaccination in a Chinese Population: Recombinant Subunit Vaccine versus Live Attenuated Vaccine [PDF]
VaccinesBackground: Currently, the recombinant subunit vaccine and live attenuated vaccine in the prevention of herpes zoster are approved for marketing in China.
Jiaqi Wang +5 more
doaj +2 more sources
HA Protein acetylation modulates replication, pathogenicity, and immunogenicity of influenza virus and facilitates live-attenuated vaccine design. [PDF]
Emerg Microbes InfectWu M +11 more
europepmc +2 more sources
Establishment and Application of Mismatch Amplification Mutation Assay-PCR for Rapid Detection and Differentiation of Duck Hepatitis A Virus-1 Attenuated Vaccine and Wild Strains [PDF]
AnimalsDuck hepatitis A virus type 1 (DHAV-1) is the main pathogen causing viral hepatitis in ducks, marked by high contagion and acute mortality. Live attenuated DHAV-1 vaccines are widely used to control the disease.
Cheng-Dong Yu +7 more
doaj +2 more sources
Evaluation of the Safety Profile of the ASFV Vaccine Candidate ASFV-G-ΔI177L
Viruses, 2022 African swine fever (ASF) is the cause of a recent pandemic that is posing a threat to much of the world swine production. The etiological agent, ASF virus (ASFV), infects domestic and wild swine, producing a variety of clinical presentations depending ...
Xuan Hanh Tran +10 more
doaj +1 more source
A live-attenuated SARS-CoV-2 vaccine candidate with accessory protein deletions
Nature Communications, 2022 A live-attenuated COVID vaccine could enrich the current vaccine portfolio. Here, Liu et al. engineer a live-attenuated SARS-CoV-2 vaccine candidate by deleting four viral accessory genes and show immunogenicity and protection in mice and hamsters.
Yang Liu +18 more
doaj +1 more source
Vaccines, 2022 The attenuated yellow fever (YF) vaccine is one of the most successful vaccines ever developed. After a single dose administration YF vaccine can induce balanced Th1/Th2 immune responses and long-lasting neutralizing antibodies. These attributes endorsed
Ana Carolina dos Reis Albuquerque Cajaraville +10 more
doaj +1 more source
H5N1 vaccine-specific B cell responses in ferrets primed with live attenuated seasonal influenza vaccines. [PDF]
PLoS ONE, 2009 Live attenuated influenza H5N1 vaccines have been produced and evaluated in mice and ferrets that were never exposed to influenza A virus infection (Suguitan et al., Plos Medicine, e360:1541, 2006).
Xing Cheng +7 more
doaj +1 more source
BioTechniques, 2022 Live attenuated Newcastle disease virus (NDV) vaccines have been used widely to protect chickens against Newcastle disease. However, the vaccine issues caused by genome mutations can seriously affect poultry health. In this study, the authors demonstrate
Kai Sun +5 more
doaj +1 more source