Results 191 to 200 of about 112,681 (232)

Immune regulation by atypical chemokine receptors

Nature Reviews Immunology, 2013
Chemokines have fundamental roles in regulating immune and inflammatory responses, primarily through their control of leukocyte migration and localization. The biological functions of chemokines are typically mediated by signalling through G protein-coupled chemokine receptors, but chemokines are also bound by a small family of atypical chemokine ...
Robert J B, Nibbs, Gerard J, Graham
openaire   +4 more sources

Atypical chemokine receptors in the immune system

Nature Reviews Immunology
Leukocyte migration is a fundamental component of innate and adaptive immune responses as it governs the recruitment and localization of these motile cells, which is crucial for immune cell priming, effector functions, memory responses and immune regulation.
Iain Comerford, Shaun R. McColl
openaire   +4 more sources

Chemokine sequestration by atypical chemokine receptors

Biochemical Society Transactions, 2006
Leucocyte migration is essential for robust immune and inflammatory responses, and plays a critical role in many human diseases. Chemokines, a family of small secreted protein chemoattractants, are of fundamental importance in this process, directing leucocyte trafficking by signalling through heptahelical G-protein-coupled receptors expressed by the ...
C A H, Hansell, C V, Simpson, R J B, Nibbs   +2 more
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Atypical chemokine receptors: emerging therapeutic targets in cancer

Trends in Pharmacological Sciences, 2022
Atypical chemokine receptors (ACKRs) regulate the availability of chemokines via chemokine scavenging, while also having the capacity to elicit downstream function through β-arrestin coupling. This contrasts with conventional chemokine receptors that directly elicit immune cell migration through G protein-coupled signaling. The significance of ACKRs in
Robert J, Torphy, Elliott J, Yee, Richard D, Schulick, Yuwen, Zhu   +3 more
openaire   +2 more sources

New nomenclature for atypical chemokine receptors

Nature Immunology, 2014
Chemokine receptors, the largest family of receptors containing a seven-transmembrane domain that are expressed on leukocytes, can be categorized into two principal subgroups that are highly related phylogenetically and cluster in the same branch of class A rhodopsin-like receptors: a larger subgroup (eighteen in humans) of G protein– coupled leukocyte
Bachelerie Françoise, Graham Gerard J., Locati Massimo, Mantovani Alberto, Murphy Philip M., Nibbs Robert, Rot Antal, Sozzani Silvano, Sozzani Silvano, Thelen Marcus   +9 more
openaire   +4 more sources

Atypical Chemokine Receptors in Inflammatory Disease

Current Molecular Medicine, 2009
There is considerable interest in the therapeutic utility of inhibiting cellular trafficking in a variety of inflammatory diseases. Approaches including inhibition of adhesion molecule function and in particular of chemokine effector function have met with high levels of success in many models of disease but have been of less value in application to ...
Manish, Patel, Iain B, McInnes, Gerard, Graham   +2 more
openaire   +2 more sources

Histone deacetylase 2 regulates STAT1-dependent upregulation of atypical chemokine receptor 3 to induce M2 macrophage migration and immune escape in hepatocellular carcinoma.

Molecular Immunology, 2022
Atypical chemokine receptor 3 (ACKR3) has been linked to the tumor microenvironment. This work investigates the effects of ACKR3 and its regulatory molecules on the chemotactic migration of tumor-associated macrophages (TAMs) in hepatocellular carcinoma (
Fu-Kun Chen, Liang Yang, Xueqiang Peng, Minghuan Mao, Xiaodan Liu, Jianbo Song, Jingyao Hu   +6 more
semanticscholar   +1 more source

Connexin 43 and Atypical Chemokine Receptor 3 in Peripheral Blood Mononuclear Cells of Patients With Aneurysmal Subarachnoid Hemorrhage.

Angiology
The expression levels of connexin 43 (Cx43) and atypical chemokine receptor 3 (ACKR3) in peripheral blood mononuclear cells (PBMCs) of patients with aneurysmal subarachnoid hemorrhage (aSAH) and their predictive value for cerebral vasospasm (CVS) were ...
Jian Yan, Dianda Chen, Jinlin Xiao, Xuye Wu, Erming Zeng, Tao Hong, Jian Duan   +6 more
semanticscholar   +1 more source

Canonical and atypical chemokine receptors in the neutrophil life cycle

Cytokine, 2023
Chemokines are mainly studied for their local function in the control of leukocyte extravasation in homeostatic and inflammatory conditions. However, they have additional roles at the systemic level including the regulation of the hematopoietic process and leukocyte differentiation.
Rachele Di Donato, Raffaella Bonecchi, Francesca Albano   +2 more
openaire   +2 more sources

Atypical chemokine receptors—“chemokine PACMANs” as new therapeutic targets in glomerulonephritis

Kidney International, 2018
Inflammatory cells are recruited to sites of inflammation by chemokines. Atypical chemokine receptors regulate chemokine gradients, thereby limiting inflammation. In this issue of Kidney International, atypical chemokine receptor 2 knockouts were described to be increasingly susceptible to immune complex-mediated glomerulonephritis.
Kathrin, Eller, Alexander R, Rosenkranz
openaire   +2 more sources