Results 201 to 210 of about 112,681 (232)

Seven structures of atypical chemokine receptor 3 reveal the molecular bases for its promiscuity and signaling bias

The FASEB Journal, 2022
Atypical chemokine receptor 3 (ACKR3) is a seven transmembrane (TM) spanning heptahelical receptor that is involved in different stages of cancer progression. Unlike canonical G protein‐coupled receptors (GPCRs), ACKR3 does not couple to heterotrimeric G
Y. Yen, Christopher T. Schafer, Martin Gustavsson, S. A. Eberle, Pawel K. Dominik, D. Deneka, Penglie Zhang, T. Schall, A. Kossiakoff, T. Handel, J. Tesmer   +10 more
semanticscholar   +1 more source

Deciphering Opioid Peptide Binding Modes at Atypical Chemokine Receptor 3.

ACS Pharmacology & Translational Science
ACKR3 is a class A G protein-coupled receptor that is considered as an atypical chemokine receptor. It does not activate G proteins but efficiently recruits β-arrestin and mediates ligand internalization and was thus proposed as a scavenger receptor ...
Friederike Wunsch, Ester Cassano, Kristina Puls, Gerhard Wolber, M. Szpakowska, A. Chevigné, Marcel Bermúdez   +6 more
semanticscholar   +1 more source

#1561 Atypical chemokine receptor 4 is involved in blood pressure regulation and ameliorates experimental glomerulonephritis

Nephrology, Dialysis and Transplantation
Hypertension is a multifactorial disease that affects nearly 50% of all adults and represents the second most prevalent cause of chronic kidney disease (CKD).
Daniel Leitinger, Stefan Russo, Corinna Schabhuettl, E. Hub, Julia Gutjahr, Maryna Samus, A. Kirsch, Philipp Eller, Alexander R Rosenkranz, K. Eller, K. Artinger, Antal Rot   +11 more
semanticscholar   +1 more source

Dissecting Trafficking and Signaling of Atypical Chemokine Receptors

2013
Atypical chemokine receptors are a distinct subset of chemokine receptors able to modulate immune responses by acting as chemokine decoy/scavengers or transporters. Intracellular trafficking properties sustained by Gαi-independent signaling have emerged as a major determinant of their biological properties, which support continuous uptake, transport ...
E. Borroni, C. Cancellieri, M. Locati, R. Bonecchi   +3 more
openaire   +3 more sources

Novel Small-Molecule Atypical Chemokine Receptor 3 Agonists: Design, Synthesis, and Pharmacological Evaluation for Antiplatelet Therapy.

Journal of Medicinal Chemistry
ACKR3, an atypical chemokine receptor, has been associated with prothrombotic events and the development of cardiovascular events. We designed, synthesized, and evaluated a series of novel small molecule ACKR3 agonists.
Alpaykut Bayrak, M. Szpakowska, Valerie Dicenta-Baunach, M. Counson, Alexander Rasch, Anne-Katrin Rohlfing, A. Chevigné, M. Gawaz, Stefan A. Laufer, Thanigaimalai Pillaiyar   +9 more
semanticscholar   +1 more source

Regulation of Endothelial Cell function by Integration of Gαi and β‐arrestin signaling at Atypical Chemokine Receptor 3

The FASEB Journal, 2022
Atypical Chemokine receptor 3 (ACKR3), also known as C‐X‐C chemokine receptor type 7 (CXCR7), is a G protein‐coupled receptor (GPCR) implicated in several physiological processes including leukocyte trafficking, cancer, and angiogenesis.
Claudia Y. Lee, Taylor Kohlmann, Xinyu Xiong, S. Rajagopal   +3 more
semanticscholar   +1 more source

Atypical chemokine receptors in tumor cell growth and metastasis

2020
Atypical chemokine receptors (ACKRs) are seven-transmembrane cell surface protein receptors expressed in immune cells, normal mesenchymal cells, and several tumor cells. As of this writing, six ACKRs have been characterized by diverse activities. They bind both cysteine-cysteine (CC) type and cysteine-X-cysteine (CXC)-type chemokines, either alone, or ...
Bal L, Lokeshwar, Georgios, Kallifatidis, James J, Hoy   +2 more
openaire   +2 more sources

Regulation of Breast Cancer Metastasis by Atypical Chemokine Receptors

Clinical Cancer Research, 2009
Abstract The interaction between chemokines and their G-protein-coupled receptors plays an important role in promoting metastasis of different kinds of human cancers. However, the expression of an atypical chemokine receptor, CCX-CKR, which serves as a decoy receptor to attract chemokines, inhibits the growth and metastasis of breast ...
Xiaoyun, Cheng, Mien-Chie, Hung
openaire   +2 more sources

The biochemistry and biology of the atypical chemokine receptors

Immunology Letters, 2012
A subset of chemokine receptors, initially called "silent" on the basis of their apparent failure to activate conventional signalling events, has recently attracted growing interest due to their ability to internalize, degrade, or transport ligands and thus modify gradients and create functional chemokine patterns in tissues.
G. J. Graham, M. Locati, A. Mantovani, A. Rot, M. Thelen   +4 more
openaire   +3 more sources

Atypical chemokine receptor 4 (ACKR4/CCX‐CKR): A comprehensive exploration across physiological and pathological landscapes in contemporary research

Cell Biochemistry and Function
Atypical chemokine receptor 4 (ACKR4), also known as CCX‐CKR, is a member of the chemokine receptor family that lacks typical G protein signaling activity.
Israa Habeeb Naser, Asia Ali Hamza, Ahmed Alhili, A. Faisal, Mohammed Shnain Ali, Noor Abdulaala Kadhim, Muath Suliman, M. Alshahrani, A. Alawadi   +8 more
semanticscholar   +1 more source