Atypical Chemokine Receptor 3 Generates Guidance Cues for CXCL12-Mediated Endothelial Cell Migration [PDF]
Frontiers in Immunology, 2019 Chemokine receptor CXCR4, its ligand stromal cell-derived factor-1 (CXCL12) and the decoy receptor atypical chemokine receptor 3 (ACKR3, also named CXCR7), are involved in the guidance of migrating cells in different anatomical districts.
Chiara Tobia +8 more
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Atypical chemokine receptor 3 induces colorectal tumorigenesis in mice by promoting β-arrestin-NOLC1-fibrillarin-dependent rRNA biogenesis. [PDF]
Acta Pharmacol Sin, 2022 Yang J +6 more
europepmc +2 more sources
Atypical Chemokine Receptor 1 (Ackr1)-deficient Mice Resist Lethal SARS-CoV-2 Challenge
bioRxiv, 2023 Majumdar S +14 more
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Prospects for targeting ACKR1 in cancer and other diseases
Frontiers in Immunology, 2023 The chemokine network is comprised of a family of signal proteins that encode messages for cells displaying chemokine G-protein coupled receptors (GPCRs).
Kyler S. Crawford, Brian F. Volkman
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Phosphoproteomic mapping of CCR5 and ACKR2 signaling properties
Frontiers in Molecular Biosciences, 2022 ACKR2 is an atypical chemokine receptor which is structurally uncoupled from G proteins and is unable to activate signaling pathways used by conventional chemokine receptors to promote cell migration.
Alessandro Vacchini +16 more
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Atypical Chemokine Receptors in Renal Inflammation [PDF]
Nephron Experimental Nephrology, 2010 Chemokines are structurally related proteins which form a large family of chemotactic cytokines. They provide a general communication system for cells and regulate lymphocyte migration. These proteins orchestrate the formation of microenvironments in lymphoid tissue, promote lymphoid organogenesis and help foster vascular and lymphatic angiogenesis. In
Segerer, S, Jedlicka, J, Wüthrich, R P
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Role of Atypical Chemokines and Chemokine Receptors Pathways in the Pathogenesis of COPD [PDF]
Current Medicinal Chemistry, 2021 Chronic obstructive pulmonary disease (COPD) represents a heightened inflammatory response in the lung generally resulting from tobacco smoking-induced recruitment and activation of inflammatory cells and/or activation of lower airway structural cells.
Francesco Nucera +10 more
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ACKR3 promotes CXCL12/CXCR4-mediated cell-to-cell-induced lymphoma migration through LTB4 production
Frontiers in Immunology, 2023 Chemotaxis is an essential physiological process, often harnessed by tumors for metastasis. CXCR4, its ligand CXCL12 and the atypical receptor ACKR3 are overexpressed in many human cancers.
Paola Antonello +10 more
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Beyond Cell Motility: The Expanding Roles of Chemokines and Their Receptors in Malignancy
Frontiers in Immunology, 2020 The anti-tumor activities of some members of the chemokine family are often overcome by the functions of many chemokines that are strongly and causatively linked with increased tumor progression.
Dina Morein +2 more
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Atypical Chemokine Receptors in Cardiovascular Disease [PDF]
Thrombosis and Haemostasis, 2019 AbstractInflammation has been well recognized as one of the main drivers of atherosclerosis development and therefore cardiovascular diseases (CVDs). It has been shown that several chemokines, small 8 to 12 kDa cytokines with chemotactic properties, play a crucial role in the pathophysiology of atherosclerosis.
Gencer, Selin +5 more
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