Results 21 to 30 of about 112,681 (232)

Targeting the atypical chemokine receptor 2 (<i>Ackr2</i>) improves the benefit of anti-PD-1 immunotherapy in melanoma mouse model. [PDF]

Oncoimmunology
Immune checkpoint blockade (ICB) therapies, such as anti-PD-1, have transformed cancer treatment, but many patients do not respond due to a non-inflammatory tumor microenvironment (TME).
Noman MZ, Szpakowska M, Xiao M, Gao R, Van Moer K, Kumar A, Ollert M, Berchem G, Chevigné A, Janji B.   +9 more
europepmc   +2 more sources

The atypical chemokine receptor-2 fine-tunes the immune response in herpes stromal keratitis. [PDF]

Front Immunol, 2022
Herpes stromal keratitis (HSK) is a blinding corneal disease caused by herpes simplex virus-1 (HSV-1), a common pathogen infecting most of the world’s population.
Yu T, Schuette F, Christofi M, Forrester JV, Graham GJ, Kuffova L.   +5 more
europepmc   +2 more sources

Corrigendum: ACKR2: An Atypical Chemokine Receptor Regulating Lymphatic Biology [PDF]

Frontiers in Immunology, 2017
Ornella Bonavita, Ornella Bonavita, Valeria Mollica Poeta, Valeria Mollica Poeta, Elisa Setten, Elisa Setten, Matteo Massara, Matteo Massara, Raffaella Bonecchi, Raffaella Bonecchi   +9 more
doaj   +4 more sources

Conformational dynamics underlying atypical chemokine receptor 3 activation

Proceedings of the National Academy of Sciences, 2023
Atypical Chemokine Receptor 3 (ACKR3) is a G protein-coupled receptor that does not signal through G proteins. It is known as a chemokine scavenger involved in various pathologies, making it an appealing yet intriguing therapeutic target.
Omolade Otun, Christelle Aljamous, Elise Del Nero, Marta Arimont-Segura, R. Bosma, B. Zarzycka, Tristan Girbau, C. Leyrat, C. de Graaf, R. Leurs, T. Durroux, S. Granier, Xiaojing Cong, Cherine Bechara   +13 more
semanticscholar   +4 more sources

Design, Synthesis and Pharmacological Characterization of the First Photoswitchable Small-Molecule Agonist for the Atypical Chemokine Receptor 3. [PDF]

ACS Omega
Photopharmacology offers the promise of optical modulation of cellular signaling in a spatially and temporally controlled fashion with light-sensitive molecules.
Bérenger S, Adamska JM, Deflorian F, de Graaf C, Palmer CB, Szpakowska M, Chevigné A, de Esch IJP, Zarzycka B, Vischer HF, Wijtmans M, Leurs R.   +11 more
europepmc   +2 more sources

Stimulation of the atypical chemokine receptor 3 (ACKR3) by a small-molecule agonist attenuates fibrosis in a preclinical liver but not lung injury model. [PDF]

Cell Mol Life Sci, 2022
Atypical chemokine receptor 3 (ACKR3, formerly CXC chemokine receptor 7) is a G protein-coupled receptor that recruits β-arrestins, but is devoid of functional G protein signaling after receptor stimulation.
Van Loy T, De Jonghe S, Castermans K, Dheedene W, Stoop R, Verschuren L, Versele M, Chaltin P, Luttun A, Schols D.   +9 more
europepmc   +2 more sources

The atypical chemokine receptor 2 reduces T cell expansion and tertiary lymphoid tissue but does not limit autoimmune organ injury in lupus-prone B6lpr mice. [PDF]

Front Immunol
Introduction The atypical chemokine receptor 2 (ACKR2) is a chemokine scavenger receptor, which limits inflammation and organ damage in several experimental disease models including kidney diseases.
Xia W, Eltrich N, Vielhauer V.
europepmc   +2 more sources

The dimeric form of CXCL12 binds to atypical chemokine receptor 1. [PDF]

Sci Signal, 2021
Biological functions of CXCL12 dimers may be modified by the atypical receptor ACKR1. An atypical pathway for chemokine action The chemokine CXCL12 functions in tissue development, vascular integrity, hematopoiesis, and immunity.
Gutjahr JC, Crawford KS, Jensen DR, Naik P, Peterson FC, Samson GPB, Legler DF, Duchene J, Veldkamp CT, Rot A, Volkman BF.   +10 more
europepmc   +2 more sources

Context-Dependent Signaling of CXC Chemokine Receptor 4 and Atypical Chemokine Receptor 3 [PDF]

Molecular Pharmacology, 2019
G protein-coupled receptors (GPCRs) are regulated by complex molecular mechanisms, both in physiologic and pathologic conditions, and their signaling can be intricate. Many factors influence their signaling behavior, including the type of ligand that activates the GPCR, the presence of interacting partners, the kinetics involved, or their location. The
Heuninck, Joyce, Perpina Viciano, Cristina, Işbilir, Ali, Caspar, Birgit, Capoferri, Davide, Briddon, Stephen J., Durroux, Thierry, Hill, Stephen J., Lohse, Martin J., Milligan, Graeme, Pin, Jean-Philippe, Hoffmann, Carsten   +11 more
exaly   +7 more sources

Atypical chemokine receptor 4 shapes activated B cell fate [PDF]

Journal of Experimental Medicine, 2018
Activated B cells can initially differentiate into three functionally distinct fates-early plasmablasts (PBs), germinal center (GC) B cells, or early memory B cells-by mechanisms that remain poorly understood.
Alsharifi, Mohammed, Babb, Rachelle, Bastow, Cameron R., Bourne, Katherine, Brink, Robert, Comerford, Iain, Cyster, Jason G., Fenix, Kevin A., Gilchrist, Derek S., Gregor, Carly E., Hermes, Jana R., Hill, Geoffrey R., Kara, Ervin E., McColl, Shaun R., McKenzie, Duncan R., Nibbs, Robert J., Norton, Todd S., Rodda, Lauren B., Tarlinton, David M., Vinuesa, Carola G., Zotos, Dimitra   +20 more
core   +9 more sources