Results 11 to 20 of about 112,681 (232)

Atypical Chemokine Receptor 3 "Senses" CXC Chemokine Receptor 4 Activation Through GPCR Kinase Phosphorylation. [PDF]

Mol Pharmacol, 2023
Atypical chemokine receptor 3 (ACKR3) is an arrestin-biased receptor that regulates extracellular chemokine levels through scavenging. The scavenging process restricts the availability of the chemokine agonist CXCL12 for the G protein-coupled receptor ...
Schafer CT, Chen Q, Tesmer JJG, Handel TM.   +3 more
europepmc   +9 more sources

Structures of atypical chemokine receptor 3 reveal the basis for its promiscuity and signaling bias. [PDF]

Sci Adv, 2022
Both CXC chemokine receptor 4 (CXCR4) and atypical chemokine receptor 3 (ACKR3) are activated by the chemokine CXCL12 yet evoke distinct cellular responses. CXCR4 is a canonical G protein–coupled receptor (GPCR), whereas ACKR3 is intrinsically biased for
Yen YC, Schafer CT, Gustavsson M, Eberle SA, Dominik PK, Deneka D, Zhang P, Schall TJ, Kossiakoff AA, Tesmer JJG, Handel TM.   +10 more
europepmc   +4 more sources

Novel neutrophil biology insights underlying atypical chemokine receptor-1/Duffy antigen receptor of chemokines-associated neutropenia. [PDF]

Curr Opin Hematol
Purpose of review Atypical chemokine receptor-1 (ACKR1)/Duffy antigen receptor of chemokines (DARC)-associated neutropenia (ADAN; OMIM 611862), previously named benign ethnic neutropenia, and present in two-thirds of individuals identifying as Black in ...
Liu JM, Luo HR.
europepmc   +4 more sources

The Role of Atypical Chemokine Receptor D6 (ACKR2) in Physiological and Pathological Conditions; Friend, Foe, or Both? [PDF]

Frontiers in Immunology, 2022
Chemokines exert crucial roles in inducing immune responses through ligation to their canonical receptors. Besides these receptors, there are other atypical chemokine receptors (ACKR1–4) that can bind to a wide range of chemokines and carry out various ...
Arezoo Gowhari Shabgah, Farhad Jadidi-Niaragh, Farhad Jadidi-Niaragh, Hamed Mohammadi, Hamed Mohammadi, Farnoosh Ebrahimzadeh, Maziar Oveisee, Abbas Jahanara, Jamshid Gholizadeh Navashenaq   +8 more
doaj   +3 more sources

The atypical chemokine receptor ACKR3/CXCR7 is a broad-spectrum scavenger for opioid peptides [PDF]

Nature Communications, 2020
Opioids modulate pain, anxiety and stress by activating four subtypes of opioid receptors. The authors show that atypical chemokine receptor 3 (ACKR3) is a scavenger for various endogenous opioid peptides regulating their availability without activating ...
Max Meyrath, Martyna Szpakowska, Julian Zeiner, Laurent Massotte, Myriam P. Merz, Tobias Benkel, Katharina Simon, Jochen Ohnmacht, Jonathan D. Turner, Rejko Krüger, Vincent Seutin, Markus Ollert, Evi Kostenis, Andy Chevigné   +13 more
doaj   +3 more sources

Small Molecule Fluorescent Ligands for the Atypical Chemokine Receptor 3 (ACKR3). [PDF]

ACS Med Chem Lett, 2023
The atypical chemokine receptor 3 (ACKR3) is a receptor that induces cancer progression and metastasis in multiple cell types. Therefore, new chemical tools are required to study the role of ACKR3 in cancer and other diseases.
Dekkers S, Comez D, Karsai N, Arimont-Segura M, Canals M, Caspar B, de Graaf C, Kilpatrick LE, Leurs R, Kellam B, Hill SJ, Briddon SJ, Stocks MJ.   +12 more
europepmc   +2 more sources

Inhibition of constitutive activity of the atypical chemokine receptor 3 by the small-molecule inverse agonist VUF16840. [PDF]

Mol Pharmacol
The atypical chemokine receptor 3 (ACKR3) has emerged as a promising drug target for the treatment of cancer, cardiovascular, and autoimmune diseases. In this study, we present the pharmacological characterization of VUF16840, the first small-molecule ...
Bosma R, Nesheva D, Rijnsburger M, Riemens R, Adamska JM, Meyrath M, Mobach S, Buzink CM, van der Pol S, de Esch IJP, Szpakowska M, Wijtmans M, Chevigne A, Vischer HF, Leurs R.   +14 more
europepmc   +2 more sources

Extended repertoire of CXC chemokines acting as agonists and antagonists of the human and murine atypical chemokine receptor ACKR2. [PDF]

J Leukoc Biol
Atypical chemokine receptors are a subfamily of important regulators of chemokine functions. Among them, ACKR2 has long been considered a scavenger of multiple inflammatory chemokines exclusively from the CC family.
Luís R, Volkman BF, Szpakowska M, Chevigné A.   +3 more
europepmc   +2 more sources

Hsa-miR-100-5p promotes the development and progression of gastric cancer through targeted atypical chemokine receptor 3. [PDF]

Int J Clin Exp Pathol
OBJECTIVES Gastric cancer (GC) ranks as the fourth most prevalent malignancy globally and is a leading cause of cancer-related mortality. This study aims to comprehensively investigate the pathogenesis of gastric cancer and propose innovative strategies ...
Wang XL, Jiang JC, Song JY, Ni JY, Song L, Xiao JZ, Fu D, Chen ZY, Cao YF.   +8 more
europepmc   +2 more sources

Bystander Expression of Atypical Chemokine Receptor 2 Protects T Cells from Chemoattraction towards Cancer-Associated Fibroblasts. [PDF]

Eur J Immunol
Atypical chemokine receptors (ACKRs) are a subclass of chemokine receptors that internalise and degrade chemokines instead of eliciting chemotaxis.
Tang R, Tay SS, Sharbeen G, Herrmann D, Youkhana J, Timpson P, Phillips PA, Biro M.   +7 more
europepmc   +2 more sources