Results 131 to 140 of about 27,026 (263)

Immune endotypes in tuberculosis: Keys to decoding disease complexity

Journal of Internal Medicine, Volume 299, Issue 6, Page 670-693, June 2026.
Abstract Tuberculosis (TB) remains a major global health challenge, with multi‐drug antibiotic regimens as the current standard of care. While effective at killing Mycobacterium tuberculosis, these treatments do not resolve persistent inflammation, prevent lung damage, or reverse immune dysregulation that contribute to poor outcomes and disease ...
Shamila D. Alipoor, Julia Guthrie, Lina Davies Forsman, Andrew R. Di Nardo, Susanna Brighenti   +4 more
wiley   +1 more source

α1‐Adrenergic Receptors Function Within Hetero‐Oligomeric Complexes With Atypical Chemokine Receptor 3 and Chemokine (C‐X‐C motif) Receptor 4 in Vascular Smooth Muscle Cells

Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, 2017
BackgroundRecently, we provided evidence that α1‐adrenergic receptors (ARs) in vascular smooth muscle are regulated by chemokine (C‐X‐C motif) receptor (CXCR) 4 and atypical chemokine receptor 3 (ACKR3). While we showed that CXCR4 controls α1‐ARs through
Lauren J. Albee, Jonathan M. Eby, Abhishek Tripathi, Heather M. LaPorte, Xianlong Gao, Brian F. Volkman, Vadim Gaponenko, Matthias Majetschak   +7 more
doaj   +1 more source

Chemokine Expression in Peripheral Tissues from the Monosodium Lodoacetate Model of Chronic Joint Pain [PDF]

, 2013
Background Chronic pain arising from degenerative diseases of the joint such as osteoarthritis (OA) has a strong peripheral component which is likely to be mediator driven. Current treatments which reduce the production of such mediators i.e.
David LH Bennett, Hannes Kiesewetter, James R Perkins, John M Dawes, Stephen B McMahon   +4 more
core   +1 more source

Single‐Cell Sequencing Reveals That CCL2+ Adipose‐Derived Stem Cells Promote Diabetic Wound Healing Through the CCL2‐ACKR1 Signaling Axis

The FASEB Journal, Volume 40, Issue 9, 15 May 2026.
scRNA‐seq of human adipose and diabetic wounds revealed a CCL2+ ADSC subpopulation with high stemness and ECM‐enriched pathways. These cells serve as a signaling hub via TGFB1‐TGFBR1, IL34‐CSF1R, and CCL2‐ACKR1. Their exosomes (CCL2‐Exos), carrying CCL2, TGFB1, and IL34, accelerate diabetic wound healing in mice by promoting angiogenesis, collagen ...
Songyun Zhao, Wanying Chen, Kaibo Liu, Jiaheng Xie, Yanming Chen, Hao Dai, Zhongqiu Lu, Longwang Chen, Yucang He, Hua Yu, Liqun Li   +10 more
wiley   +1 more source

G-Protein Coupled Receptor Targeting on Myeloid Cells in Atherosclerosis

Frontiers in Pharmacology, 2019
Atherosclerosis, the underlying cause of the majority of cardiovascular diseases (CVDs), is a lipid-driven, inflammatory disease of the large arteries.
Emiel P. C. van der Vorst, Emiel P. C. van der Vorst, Emiel P. C. van der Vorst, Emiel P. C. van der Vorst, Linsey J. F. Peters, Madeleine Müller, Selin Gencer, Yi Yan, Christian Weber, Christian Weber, Christian Weber, Yvonne Döring, Yvonne Döring   +12 more
doaj   +1 more source

Synthetic and Endogenous Cannabinoids Inhibit Breast Cancer Cell Growth and Metastasis [PDF]

, 2011
With one million cases diagnosed yearly worldwide, breast cancer is the second most common cancer in women. Metastasis to the brain is the leading cause of death in breast cancer patients due to the inability of drug treatments to cross the blood brain ...
Smith, Diane
core  

GPND‐AI NULISA: A 15‐Protein AI classifier for diagnosis and co‐pathology profiling across neurodegenerative diseases

Alzheimer's &Dementia, Volume 22, Issue 5, May 2026.
Abstract INTRODUCTION Accurate clinical diagnosis of neurodegenerative diseases remains challenging, particularly when individuals have mixed pathologies. We implemented the generalizable protein‐based neurodegenerative disease artificial intelligence (GPND‐AI) classifier using the NUcleic acid‐Linked Immuno‐Sandwich Assay (NULISA) central nervous ...
Ying Xu, Marisa N Denkinger, Menghan Liu, Katherine Gong, Yike Chen, Daniel Western, Jigyasha Timsina, Yuchen Cheng, Yunchang Xie, Rui Mu, John Budde, Thomas G. Beach, Geidy E. Serrano, Eric M. Reiman, Alpana Singh, Isabel Alfradique‐Dunham, Tammie L. S. Benzinger, Suzanne E. Schindler, John C. Morris, David M. Holtzman, Joel S. Perlumtter, B Joy Snider, Meghan C. Campbell, Paul T. Kotzbauer, Nicholas J. Ashton, Carlos Cruchaga   +25 more
wiley   +1 more source

Expression of the chemokine decoy receptor D6 mediates dendritic cell function and promotes corneal allograft rejection [PDF]

, 2014
Purpose To identify the role of chemokine receptor 6 (D6) expression by dendritic cells (DCs) and its role in corneal transplant immunity. Methods: Flow cytometry analysis was used to assess the expression level of the D6 chemokine receptor in different ...
Chauhan, Sunil K., Dana, Reza, Hajrasouliha, Amir R., Lee, Hyung K., Sadrai, Zahra   +4 more
core  

The Role of Atypical Chemokine Receptor CCXCKR (CCRL1) in Human Diseases [PDF]

, 2016
Parvin Salimi, Abolghasem Esmaeili
openalex   +1 more source

Chronic Inflammatory Demyelinating Polyneuropathy (CIDP): A Comprehensive Review of Types, Pathophysiology, and Treatment Approaches

Brain and Behavior, Volume 16, Issue 5, May 2026.
Chronic inflammatory demyelinating polyneuropathy is an autoimmune disorder causing demyelination, leading to distal weakness, sensory loss, and autonomic dysfunction. Immune activation triggers macrophage‐mediated myelin damage and conduction failure.
Ayesha Khan, Arsal Khan, Kuldeep Dalpat Rai, Anzel Saeed, Harsh Kumar, Aneesh Kumar Sangtiani, Tehreem Fatima, Muhammad Tanveer Alam, Faiza Rajput, Sakshi Chawla, Hussain Haider Shah, Humaira Kalam   +11 more
wiley   +1 more source