Results 141 to 150 of about 27,026 (263)

Identification of critical residues at the C-terminal tip of ACKR4 regulating chemokine internalization and βarrestin involvement

Cell Communication and Signaling
Background Atypical chemokine receptors (ACKRs) play an important role in regulating the availability of chemokines and are responsible for the formation of chemokine gradients required for the directed migration of immune cells in health and disease ...
Oliver J. Gerken, Nicola Catone, Daniel F. Legler   +2 more
doaj   +1 more source

Distinct activation mechanisms of CXCR4 and ACKR3 revealed by single-molecule analysis of their conformational landscapes

eLife
The canonical chemokine receptor CXCR4 and atypical receptor ACKR3 both respond to CXCL12 but induce different effector responses to regulate cell migration.
Christopher T Schafer, Raymond F Pauszek III, Martin Gustavsson, Tracy M Handel, David P Millar   +4 more
doaj   +1 more source

Deficiency of Duffy Antigen Receptor for Chemokines Ameliorated Cochlear Damage From Noise Exposure

Frontiers in Molecular Neuroscience, 2018
Cochlear inflammatory response to various environmental insults, including acoustic and ototoxic overexposures, has been increasingly become a topic of interest.
Bouchra Edderkaoui, Bouchra Edderkaoui, Liana Sargsyan, Alisa Hetrick, Hongzhe Li, Hongzhe Li, Hongzhe Li   +6 more
doaj   +1 more source

Supplementary Figure 2 from ERK-Dependent Downregulation of the Atypical Chemokine Receptor D6 Drives Tumor Aggressiveness in Kaposi Sarcoma [PDF]

, 2023
Benedetta Savino, Nicoletta Caronni, Achille Anselmo, Fabio Pasqualini, Elena Monica Borroni, Gianluca Basso, Giuseppe Celesti, Luigi Laghi, Athanasia Tourlaki, V. Boneschi, Lucia Brambilla, Manuela Nebuloni, Gianluca Vago, Alberto Mantovani, Massimo Locati, Raffaella Bonecchi   +15 more
openalex   +1 more source

The Immune Landscape of Acral Melanoma: From Basic to Clinical

Cancer Medicine, Volume 15, Issue 5, May 2026.
ABSTRACT Background Acral melanoma (AM) is an aggressive melanoma subtype with poor prognosis and limited response to immune checkpoint inhibitors (ICIs). Despite increasing research efforts, the mechanisms underlying therapeutic resistance remain incompletely understood.
Lihong Jiang, Zhaotian Zhang
wiley   +1 more source

Novel neutrophil biology insights underlying atypical chemokine receptor-1/Duffy antigen receptor of chemokines-associated neutropenia

Current Opinion in Hematology
Purpose of review Atypical chemokine receptor-1 (ACKR1)/Duffy antigen receptor of chemokines (DARC)-associated neutropenia (ADAN; OMIM 611862), previously named benign ethnic neutropenia, and present in two-thirds of individuals identifying as Black in the USA, is associated with mild to moderate decreases in peripheral ...
Liu, Johnson M., Luo, Hongbo R.
openaire   +2 more sources

Simultaneous Establishment of Autologous Colorectal Cancer and Mesothelial Stromal Cell Lines from Malignant Ascites Reveals a Mesothelial‐Stromal FGFR3 Axis as a Potential Vulnerability in Peritoneal Metastasis

Cancer Medicine, Volume 15, Issue 5, May 2026.
ABSTRACT Colorectal cancer (CRC) with peritoneal dissemination remains a major therapeutic challenge because of poor prognosis and limited treatment options. Experimental models that accurately recapitulate tumor–mesothelial interactions are scarce. Here, we report the establishment of a novel autologous paired model comprising a CRC cell line (OMUCR‐1)
Yasuhiro Fukui, Hiroaki Kasashima, Zizhou Wang, Iguru Omori, Yukina Kusunoki, Kanae Echizen, Yoshiki Nonaka, Yuki Seki, Kenji Kuroda, Yuichiro Miki, Mami Yoshii, Tatsunari Fukuoka, Tatsuro Tamura, Masatsune Shibutani, Takahiro Toyokawa, Yu Muta, Yuki Nakanishi, Masakazu Yashiro, Naoko Ohtani, Kiyoshi Maeda   +19 more
wiley   +1 more source

The role of the atypical chemokine receptor CCRL2 in myelodysplastic syndrome and secondary acute myeloid leukemia

, 2022
Theodoros Karantanos, Patric Teodorescu, Brandy Perkins, Ilias Christodoulou, Christopher Esteb, Ravi Varadhan, Eric Helmenstine, Trivikram Rajkhowa, Bogdan C. Paun, Challice L. Bonifant, W. Brian Dalton, Lukasz P. Gondek, Alison R. Moliterno, Mark J. Levis, Gabriel Ghiaur, Richard J. Jones   +15 more
openalex   +1 more source

GPR182 is an endothelium-specific atypical chemokine receptor that maintains hematopoietic stem cell homeostasis [PDF]

, 2021
Alan Le Mercier, Rémy Bonnavion, Weijia Yu, Mohamad Wessam Alnouri, Sophie Ramas, Yang Zhang, Yannick Jäger, Kenneth Anthony Roquid, Hyun‐Woo Jeong, Kishor K. Sivaraj, Haaglim Cho, Xinyi Chen, Boris Strilić, Tjeerd Sijmonsma, Ralf H. Adams, Timm Schroeder, Michael A. Rieger, Stefan Offermanns   +17 more
openalex   +1 more source

Trimethoprim/Sulfamethoxazole‐Induced Systemic Toxic Epidermal Necrolysis Syndrome: A Case Report

Clinical Case Reports, Volume 14, Issue 5, May 2026.
ABSTRACT Trimethoprim/sulfamethoxazole can induce life‐threatening toxic epidermal necrolysis. Early recognition, immediate drug cessation, and multidisciplinary supportive care are critical. Even with aggressive therapy, mortality remains high, and SCORTEN score aids in prognostication.
Qing Wang, Litong Chen, Wen Ye
wiley   +1 more source