Exp Cell Res, 2011 Atypical chemokine receptors (ACRs) are cell surface receptors with seven transmembrane domains structurally homologous to chemokine G-protein coupled receptors (GPCRs). However, upon ligation by cognate chemokines, ACRs fail to induce classical signaling and downstream cellular responses characteristic for GPCRs.
Ulvmar MH, Hub E, Rot A.
europepmc +4 more sources
Large chemokine binding spectrum of human and mouse atypical chemokine receptor GPR182 (ACKR5)
Frontiers in Pharmacology, 2023 Atypical chemokine receptors (ACKRs) play pivotal roles in immune regulation by binding chemokines and regulating their spatial distribution without inducing G-protein activation.
Remy Bonnavion +8 more
doaj +4 more sources
The atypical chemokine receptor ACKR2 is protective against sepsis [PDF]
Shock, 2018 Sepsis is a systemic inflammatory response as a result of uncontrolled infections. Neutrophils are the first cells to reach the primary sites of infection and chemokines play a key role in recruiting neutrophils.
Alves-Filho, José Carlos +15 more
core +5 more sources
Evaluation of Atypical Chemokine Receptor Expression in T Cell Subsets
Cells, 2022 Chemokines are molecules that pertain to a family of small cytokines and can generate cell chemotaxis through the interaction with their receptors.
Messias Oliveira Pacheco +3 more
doaj +3 more sources
Atypical chemokine receptor 4 shapes activated B cell fate [PDF]
Journal of Experimental Medicine, 2018 Activated B cells can initially differentiate into three functionally distinct fates-early plasmablasts (PBs), germinal center (GC) B cells, or early memory B cells-by mechanisms that remain poorly understood.
Alsharifi, Mohammed +20 more
core +9 more sources
Distinct activation mechanisms of CXCR4 and ACKR3 revealed by single-molecule analysis of their conformational landscapes [PDF]
eLifeThe canonical chemokine receptor CXCR4 and atypical receptor ACKR3 both respond to CXCL12 but induce different effector responses to regulate cell migration.
Christopher T Schafer +4 more
doaj +2 more sources
Atypical chemokine receptors: emerging therapeutic targets in cancer. [PDF]
Trends Pharmacol Sci, 2022 Atypical chemokine receptors (ACKRs) regulate the availability of chemokines via chemokine scavenging, while also having the capacity to elicit downstream function through β-arrestin coupling. This contrasts with conventional chemokine receptors that directly elicit immune cell migration through G protein-coupled signaling. The significance of ACKRs in
Torphy RJ, Yee EJ, Schulick RD, Zhu Y.
europepmc +3 more sources
Atypical chemokine receptor 2 expression is directly regulated by hypoxia inducible factor-1 alpha in cancer cells under hypoxia [PDF]
Scientific ReportsLack of significant and durable clinical benefit from anti-cancer immunotherapies is partly due to the failure of cytotoxic immune cells to infiltrate the tumor microenvironment.
Alice Benoit +4 more
doaj +2 more sources
Chemokine (C-X-C Motif) Receptor 4 and Atypical Chemokine Receptor 3 Regulate Vascular α1-Adrenergic Receptor Function [PDF]
Molecular medicine (Cambridge, Mass.), 2014 Chemokine (C-X-C motif) receptor (CXCR) 4 and atypical chemokine receptor (ACKR) 3 ligands have been reported to modulate cardiovascular function in various disease models. The underlying mechanisms, however, remain unknown. Thus, it was the aim of the present study to determine how pharmacological modulation of CXCR4 and ACKR3 regulate cardiovascular ...
Harold H. Bach +7 more
openalex +3 more sources
Development of specific anti-mouse atypical chemokine receptor 4 monoclonal antibodies
Biochemistry and Biophysics ReportsLeukocyte migration is an essential function of innate and adaptive immune responses. Chemokines and their receptors control the migration system. The abundance of chemokines is controlled by atypical chemokine receptors (ACKRs), chemokine receptor-like ...
Miu Hirose +5 more
doaj +3 more sources