Results 31 to 40 of about 28,527 (253)
Atypical activation and molecular glue-like dimerization mechanism of an intrinsically-biased chemokine receptor [PDF]
Banerjee N +20 more
europepmc +2 more sources
Genes and Diseases, 2022 Obesity-induced inflammation, characterized by augmented infiltration and altered balance of macrophages, is a critical component of systemic insulin resistance. Chemokine-chemokine receptor system plays a vital role in the macrophages accumulation.
Min Xu +8 more
doaj +1 more source
Multiple Roles for Chemokines in Neutrophil Biology
Frontiers in Immunology, 2020 Chemokines are recognized as the most critical mediators for selective neutrophil recruitment during inflammatory conditions. Furthermore, they are considered fundamental regulators of neutrophil mobilization from the bone marrow (BM) to the bloodstream ...
Arianna Capucetti +4 more
doaj +1 more source
Context-Dependent Signaling of CXC Chemokine Receptor 4 and Atypical Chemokine Receptor 3 [PDF]
Molecular Pharmacology, 2019 G protein-coupled receptors (GPCRs) are regulated by complex molecular mechanisms, both in physiologic and pathologic conditions, and their signaling can be intricate. Many factors influence their signaling behavior, including the type of ligand that activates the GPCR, the presence of interacting partners, the kinetics involved, or their location. The
Heuninck, Joyce +11 more
openaire +5 more sources
Conformational dynamics underlying Atypical Chemokine Receptor 3 activation
Proceedings of the National Academy of Sciences, 2023 AbstractAtypical Chemokine Receptor 3 (ACKR3) is a G protein-coupled receptor that does not signal through G proteins. It is known as a chemokine scavenger involved in various pathologies, making it an appealing yet intriguing therapeutic target. Indeed, the structural properties that govern ACKR3 functional selectivity and the overall conformational ...
Omolade Otun +13 more
openaire +3 more sources
Atypical Chemokine Receptors in Cardiovascular Disease [PDF]
Thrombosis and Haemostasis, 2019 AbstractInflammation has been well recognized as one of the main drivers of atherosclerosis development and therefore cardiovascular diseases (CVDs). It has been shown that several chemokines, small 8 to 12 kDa cytokines with chemotactic properties, play a crucial role in the pathophysiology of atherosclerosis.
Gencer, Selin +5 more
openaire +3 more sources
Chemokine Receptors and Phagocyte Biology in Zebrafish
Frontiers in Immunology, 2020 Phagocytes are highly motile immune cells that ingest and clear microbial invaders, harmful substances, and dying cells. Their function is critically dependent on the expression of chemokine receptors, a class of G-protein-coupled receptors (GPCRs ...
Frida Sommer +2 more
doaj +1 more source
Atypical chemokine receptors: from silence to sound [PDF]
Biochemical Society Transactions, 2013 ACRs (atypical chemokine receptors) were initially referred to as ‘silent’ receptors on the basis of a lack of signalling and functional activities that are typically observed with conventional chemokine receptors. Although ACRs do not directly induce cell migration, they indirectly control leucocyte recruitment by shaping chemokine gradients in ...
C. Cancellieri +4 more
openaire +2 more sources
Molecular Pharmacology, 2023 AbstractAtypical chemokine receptor 3 (ACKR3) is an arrestin-biased receptor that regulates extracellular chemokine levels through scavenging. The scavenging action mediates the availability of the chemokine CXCL12 for the G protein-coupled receptor (GPCR) CXCR4 and requires phosphorylation of the ACKR3 C-terminus by GPCR kinases (GRKs).
Christopher T. Schafer +3 more
openaire +6 more sources
Chemokines, molecular drivers of thromboinflammation and immunothrombosis
Frontiers in Immunology, 2023 Blood clotting is a finely regulated process that is essential for hemostasis. However, when dysregulated or spontaneous, it promotes thrombotic disorders.
Julian Leberzammer +4 more
doaj +1 more source