Results 11 to 20 of about 2,249 (120)

The value of repeat kidney biopsy during an atypical course of membranous nephropathy

BMC Nephrology, 2022
Background The clinical trajectory for patients with primary membranous nephropathy ranges widely from spontaneous remission to a rapid decline in kidney function.
Sumaiya Ahmed, David Massicotte-Azarniouch, Mark Canney, Clare Booth, Paula Blanco, Gregory L. Hundemer   +5 more
doaj   +1 more source

CHAPLE‐Like Enteropathy and Renal Microangiopathy in an Adult Patient With CD46 Deficiency [PDF]

J Clin Lab Anal
We report an adult patient with a homozygous CD46 variant presenting with lifelong protein‐losing enteropathy, intestinal lymphangiectasia, and CVID‐like hypogammaglobulinemia mimicking CHAPLE syndrome. Concurrent renal biopsy revealed PLA2R‐negative membranous nephropathy with chronic thrombotic microangiopathy, establishing multi‐organ complement ...
Erden B, Korkmaz P, Yazici H, Dirim A, Beşışık F, Kahveci N, Kilinc Z, Unal D, Yegit O, Kalaycı T, Hürdoğan Ö, Özlük Y, Büyük M, Gelincik A, Demir S.   +14 more
europepmc   +2 more sources

Case Report: Atypical Manifestations Associated With FOXP3 Mutations. The “Fil Rouge” of Treg Between IPEX Features and Other Clinical Entities?

Frontiers in Immunology, 2022
IntroductionThe Forkhead box protein P3 (FOXP3) is a transcription factor central to the function of regulatory T cells (Treg). Mutations in the FOXP3 gene lead to a systemic disease called immune dysregulation, polyendocrinopathy, and enteropathy, an X ...
Micaela Gentile, Micaela Gentile, Maurizio Miano, Paola Terranova, Stefano Giardino, Maura Faraci, Filomena Pierri, Enrico Drago, Daniela Verzola, Gianmarco Ghiggeri, Enrico Verrina, Andrea Angeletti, Barbara Cafferata, Alice Grossi, Isabella Ceccherini, Gianluca Caridi, Francesca Lugani, Lorenzo Nescis, Enrico Fiaccadori, Enrico Fiaccadori, Luca Lanino, Daniela Fenoglio, Daniela Fenoglio, Edoardo La Porta, Edoardo La Porta   +24 more
doaj   +1 more source

Clinical periodontal diagnosis

Periodontology 2000, EarlyView., 2023
Abstract Periodontal diseases include pathological conditions elicited by the presence of bacterial biofilms leading to a host response. In the diagnostic process, clinical signs such as bleeding on probing, development of periodontal pockets and gingival recessions, furcation involvement and presence of radiographic bone loss should be assessed prior ...
Giovanni E. Salvi, Andrea Roccuzzo, Jean‐Claude Imber, Alexandra Stähli, Björn Klinge, Niklaus P. Lang   +5 more
wiley   +1 more source

Deposition of the Membrane Attack Complex in Healthy and Diseased Human Kidneys

Frontiers in Immunology, 2021
The membrane attack complex—also known as C5b-9—is the end-product of the classical, lectin, and alternative complement pathways. It is thought to play an important role in the pathogenesis of various kidney diseases by causing cellular injury and tissue
Jacob J. E. Koopman, Jacob J. E. Koopman, Mieke F. van Essen, Helmut G. Rennke, Aiko P. J. de Vries, Cees van Kooten   +5 more
doaj   +1 more source

Distinct Complement Activation Profiles Between NELL1‐ and PLA2R‐Associated Membranous Nephropathy: A Clinicopathological and Proteomic Study [PDF]

Nephrology (Carlton)
We compared the clinicopathological features and complement activation profiles of PLA2R‐associated and NELL1‐associated membranous nephropathy. NELL1‐associated membranous nephropathy was associated with older age, more chronic histologic changes and less glomerular C3 and C4d deposition.
Suzuki T, Dedong K, Kawanishi K, Ueda M, Kajio Y, Kobayashi K, Kanazawa N, Takahashi‐Kobayashi M, Usui J, Baba M, Honda H, Honda K, Iyoda M.   +12 more
europepmc   +2 more sources

Renal Biopsy in Patients with Diabetes: Indications, Results, and Clinical Predictors of Diabetic Kidney Disease

Turkish Journal of Nephrology, 2021
Objective: Diabetic kidney disease (DKD) is one of the most common etiologies of end-stage kidney disease. Kidney biopsies are performed less frequently in patients with diabetes; however, these patients can have glomerular diseases other than diabetic ...
Ayşe Serra Artan, Meltem Gürsu, Ganime Çoban, Ömer Celal Elçioğlu, Rumeyza Kazancıoğlu   +4 more
doaj   +1 more source

Complement Inhibitors in Clinical Trials for Glomerular Diseases

Frontiers in Immunology, 2019
Defective complement action is a cause of several human glomerular diseases including atypical hemolytic uremic syndrome (aHUS), anti-neutrophil cytoplasmic antibody mediated vasculitis (ANCA), C3 glomerulopathy, IgA nephropathy, immune complex ...
Peter F. Zipfel, Peter F. Zipfel, Thorsten Wiech, Ramona Rudnick, Sara Afonso, Fermin Person, Christine Skerka   +6 more
doaj   +1 more source

Idiopathic membranous nephropathy with renal amyloidosis: A case report

Frontiers in Medicine, 2022
BackgroundImmunoglobulin light chain amyloidosis is a clonal, non-proliferative plasma cell disorder, in which fragments of immunoglobulin light chain are deposited in tissues.
Yue Wang, Xueyao Wang, Jinyu Yu, Shan Wu, Zhonggao Xu, Weixia Sun   +5 more
doaj   +1 more source

Podocyte Infolding Glomerulopathy, First Case Report From North America

Canadian Journal of Kidney Health and Disease, 2021
Rationale: Podocyte infolding glomerulopathy (PIG) is a newly described condition with only 37 cases reported worldwide. Due to its rarity, the pathogenesis and evolution of this disease is unclear.
Julie Anne Ting, Wayne Hung, Susanna A. McRae, Sean J. Barbour, Michael Copland, Maziar Riazy   +5 more
doaj   +1 more source