Results 31 to 40 of about 2,249 (120)

Interleukin‐12: Central Roles in Immune Regulation and Disease Therapy

Immunology &Cell Biology, EarlyView.
IL‐12 levels are tightly regulated to balance effective protective immunity against infections and cancer with the risk of excessive inflammation and autoimmune disease. Both insufficient and excessive IL‐12 activity can therefore be detrimental, highlighting the importance of precisely controlling its production and signaling. ABSTRACT Interleukin‐12 (
Anthi Psoma, Geert van den Bogaart
wiley   +1 more source

Diagnostic model based on machine learning with multi‐feature analysis for diabetic peripheral neuropathy in type 2 diabetes: A single‐center retrospective study

Journal of Diabetes Investigation, EarlyView.
ABSTRACT Objective Diabetic peripheral neuropathy (DPN) is a common and serious complication of diabetes, which imposes a significant economic burden on both society and individuals. Therefore, early identification and diagnosis are crucial for the prevention and treatment of DPN.
Xi Zheng, Keke Yang, Ruyi Qu, Xiaomin Peng, Ling Yang   +4 more
wiley   +1 more source

Case report: Nephrotic syndrome and portal hypertensive ascites after allogeneic hematopoietic stem cell transplantation: a rare manifestation of chronic graft-versus-host disease

Frontiers in Immunology
Chronic graft-versus-host disease (GVHD) is a major complication after allogeneic hematopoietic stem cell transplantation (HSCT). Chronic GVHD may have atypical manifestations affecting non-classical organs.
SanXi Ai, YuBing Wen, XiaoHong Fan, TianRui Hua, Wei Ye, XueMei Li, Yan Qin   +6 more
doaj   +1 more source

Neutrophils: Heterogeneity, Biology, Diseases, and Therapeutic Strategies

MedComm, Volume 7, Issue 11, November 2026.
Neutrophils exhibit remarkable functional plasticity and play dual roles in tissue protection and disease progression. This review summarizes their key biological functions and highlights the shift from conventional broad‐spectrum interventions to neutrophil‐based drug delivery systems.
Yibing Zhang, Siwen Wu, Yusi Wang, Die Hu, Li Yang   +4 more
wiley   +1 more source

Phospholipase A2 receptor-negative membranous nephropathy presenting as a rare renal manifestation of IgG4-related disease

SAGE Open Medical Case Reports
IgG4-related disease is a fibroinflammatory condition characterized by dense lymphoplasmacytic infiltrates rich in IgG4-positive plasma cells affecting multiple organs.
Srikar Sama, Alexander Weickhardt, Preethi Subramanian, Pooja Reddy   +3 more
doaj   +1 more source

The value of renal biopsy in PLA2R- antibody-positive patients with proteinuria: impact of additional pathologies on management and prognosis in a Chinese Cohort

Frontiers in Physiology
IntroductionThe detection of serum anti-phospholipase A2 receptor (PLA2R) antibodies (SAbs), a method to diagnose membranous nephropathy (MN) that replaces renal biopsy, is becoming increasingly accepted.
Shan Lu, Xiaoyang Wang, Xiaoxue Wang, Mengjiao Zhao, Hong Li, Zhanzheng Zhao   +5 more
doaj   +1 more source

Animal models of anemia of inflammation: Methodological advances, limitations, and translational applications

Animal Models and Experimental Medicine, Volume 9, Issue 10, Page 1982-2000, October 2026.
Anemia of inflammation is a highly prevalent secondary anemia complicating chronic inflammatory diseases. Current animal models are categorized into sterile inflammation, disease‐specific, and genetically engineered models, with comparative analysis of their modeling principles, characteristic phenotypes, and translational advantages to elucidate core ...
Jiayi Cheng, Xiaodi Zhou, Qian Liu, Zixian Liu, Hao Wu   +4 more
wiley   +1 more source

Case Report: Membranous nephropathy associated with mantle cell lymphoma: a rare case

Frontiers in Medicine
Mantle cell lymphoma (MCL) is a rare, aggressive non-Hodgkin lymphoma (NHL) that can affect the kidneys. In this research, we described a very rare case of secondary membranous nephropathy (MN) associated with MCL.
Mian Ren, Luxi Cao, Quanquan Shen, Bin Zhu, Juan Wu   +4 more
doaj   +1 more source

Suboptimal Response to Eculizumab in Renal‐Limited Thrombotic Microangiopathy Associated With Malignant Hypertension and Monoclonal Gammopathy: A Case Report

Clinical Case Reports, Volume 14, Issue 10, October 2026.
ABSTRACT Renal‐limited thrombotic microangiopathy (TMA) is clinically milder but etiologically complex and is often underdiagnosed. This case presents as complement‐mediated TMA with malignant hypertension and monoclonal gammopathy but showed suboptimal response to eculizumab treatment, suggesting heterogeneity in both etiology and treatment outcomes.
Wenjuan Lei, Tianli Shi, Man Xu, Jun Zhou   +3 more
wiley   +1 more source

Human biomarker navigator

iMeta, Volume 5, Issue 5, October 2026.
The Human Biomarker Navigator integrates the disease continuum, biomarker dynamics, cross‐organ biomarker networks, biomarker classification, and technology‐driven paradigms. It maps how biomarkers link multi‐system physiology and pathology across the nervous, respiratory, endocrine, circulatory, immune, digestive, urinary, reproductive, and ...
Meng‐Yao Li, Qian Zhang, Zijie Wang, Zeping Gui, Jing Liu, Jingda Li, Maojun Jiang, Zukang Chang, Qingqing Han, Bendong Yang, Tariq Saeed, Jun Li, Jinghan Jia, Chenghu Song, Tong Shao, Tianhuan Peng, Xueying Zhang, Pingping Guo, Jun Luo, Gangao Yang, Yuan Wan, Gokhan Zengin, Quan Yuan, Lingru Li, Xiaohui Fan, Yang Luo, Lvyun Zhu, Yanfei Zheng, Wenjun Mao, Wenlong Sun   +29 more
wiley   +1 more source