Results 51 to 60 of about 2,249 (120)

New Anticomplement Drugs in Nephrology: Mechanism and Indication

Kidney & Blood Pressure Research
Background: The complement system is a key component of innate immunity, critical for pathogen defense, inflammation, and immune regulation.
Lucia Macciò, Elisa Russo, Francesca Costigliolo, Yuri Battaglia, Francesca Viazzi, Pasquale Esposito   +5 more
doaj   +1 more source

Non-Diabetic Kidney Disease in Type 2 Diabetic Patients: Prevalence, Clinical Predictors and Outcomes

Kidney & Blood Pressure Research, 2017
Background/Aims: Diabetic kidney disease (DKD) is one of the most frequent microvascular complications of diabetes and is the leading cause of end-stage kidney disease worldwide.
Siyar  Erdogmus, Saba Kiremitci, Zeynep Kendi Celebi, Serkan Akturk, Neval Duman, Kenan Ates, Sehsuvar Erturk, Gokhan Nergizoglu, Sim Kutlay, Sule Sengul, Arzu Ensari, Kenan Keven   +11 more
doaj   +1 more source

Type 2 Diabetes Mellitus: Molecular Pathogenesis and Therapeutic Interventions

MedComm, Volume 7, Issue 8, August 2026.
This graphical summary illustrates the multiorgan therapeutic landscape for Type 2 diabetes mellitus (T2D), integrating molecular pathogenesis with modern treatment strategies. It depicts how current interventions, including SGLT2 inhibitors, GLP‐1 receptor agonists, and insulin secretagogues, target key organs—kidney, pancreas, gastrointestinal tract,
Shinuan Fei, Xiyue Xiong, Lu Zhang, Jian Zhang, Lawrence W. C. Chan, Hong Jiang, Qingqing Xiong, Changtao Hu, Jie Chen, Sijun Yang   +9 more
wiley   +1 more source

Differentiating the Clinical and Variant Spectrum of Hardikar Syndrome From Other MED12 ‐Related Developmental Disorders

American Journal of Medical Genetics Part A, Volume 200, Issue 7, Page 1619-1650, July 2026.
ABSTRACT The rare X‐linked female‐restricted Hardikar syndrome (HDKR, OMIM # 301068) is characterized by multiple congenital anomalies including orofacial clefts, gastrointestinal, genitourinary, and cardiac anomalies, but cognitive and neurobehavioral development is rarely impaired.
Tinne Warmoeskerken, Miel Theunis, Kris Van den Bogaert, Koenraad Devriendt, Jeroen Breckpot   +4 more
wiley   +1 more source

Living Donor Kidney Transplantation in High-Recurrence Kidney Diseases: Precision Risk Stratification and Management

Kidney International Reports
Living-donor kidney transplantation (KT) offers the best outcomes for patients with kidney failure (KF). However, recurrence of primary kidney disease in the allograft remains a major concern and represents 1 of the leading causes of graft loss ...
Catherine Verhellen, Arnaud Devresse, Valentine Gillion, Elliott Van Regemorter, Tom Darius, Antoine Buemi, Eric Goffin, Nada Kanaan   +7 more
doaj   +1 more source

Membranous Nephropathy: Advances in Diagnosis and Treatment, with an Eye on PLA2R1-Negative Forms

Kidney and Dialysis
Membranous nephropathy (MN) is an immune complex-mediated glomerular disease defined by sub-epithelial deposits that trigger complement activation and podocyte injury. Its pathogenesis reflects loss of immune tolerance and may present as a kidney-limited
Micaela Anna Casiraghi, Anna J. Peired, Adele Mitrotti, Fiammetta Ravaglia, Giuseppe Spatoliatore, Francesca Digennaro, Loreto Gesualdo, Augusto Vaglio   +7 more
doaj   +1 more source

Evolution of idiopathic membranous nephropathy to class v lupus nephritis: a case report and literature review

Frontiers in Medicine
BackgroundThe M-type phospholipase A2 receptor (PLA2R) antibody positivity is considered a specific serological marker for idiopathic membranous nephropathy (IMN), and its presence in class V lupus nephritis (LN) is rare.
Bo Shen, Cheng Peng, Weicheng Xiao
doaj   +1 more source

A membranous nephropathy variant mimicking minimal change disease

The Journal of Pathology: Clinical Research
This study characterizes a novel disease pattern of membranous nephropathy (MN) that exhibits overlapping clinicopathological features with minimal change disease (MCD), termed ‘MCD‐like MN’.
Chuqi Pan, Silin Xiang, Mengya Jiang, Yuan Li, Biao Huang, Tian Ye, Yuanyuan Du, Xuanli Tang, Yuan Yuan   +8 more
doaj   +1 more source

Prevalence and Factors Predicting Nondiabetic Kidney Disease in Type 2 Diabetic Patients

Indian Journal of Kidney Diseases
Background: Renal involvement in type 2 diabetes is mostly presumed to be due to diabetic nephropathy; however, a significant majority of diabetic patients can have pure nondiabetic kidney disease (NDKD) or NDKD superimposed on diabetic kidney disease ...
Vignesh Subramani, Vaishnavi Venkatasubramanian, Jasmine Sethi, Aravind Sekar, Ritambhra Nada, Manish Rathi   +5 more
doaj   +1 more source

Diagnostic value of renal biopsy in anti-phospholipase A2 receptor antibody-positive patients with proteinuria in China

Scientific Reports
Renal biopsy remains the gold standard for diagnosing membranous nephropathy (MN). Recent studies have suggested that renal biopsy can be replaced with the serum phospholipase A2 receptor (PLA2R) antibody test for MN diagnosis in patients with nephrotic ...
Shan Lu, Jing Xiao, Dong Liu, Yan Zhang, Yijun Dong, Zhanzheng Zhao   +5 more
doaj   +1 more source