Results 41 to 50 of about 2,249 (120)

Iron and Other Metal Ions in Human Health and Disease

MedComm, Volume 7, Issue 10, October 2026.
Iron, copper, zinc, and calcium orchestrate cellular function through distinct yet cooperative mechanisms: redox‐active iron and copper cycle between oxidation states to act as Fenton catalysts and electron carriers in oxidative phosphorylation (OXPHOS); redox‐inert zinc serves as a structural component of zinc‐finger proteins and a catalytic cofactor ...
Xiaofeng Dai, Jitian Li
wiley   +1 more source

Broadening horizons: Pathogenesis and therapeutics of renal ciliopathies

Journal of Cell Communication and Signaling, Volume 20, Issue 3, September 2026.
This review elucidates the molecular mechanisms and aberrant signaling pathways in renal ciliopathies, links genetic heterogeneity to clinical phenotypes, and lays a theoretical basis for prenatal diagnosis and novel therapies. Abstract Renal ciliopathies encompass a spectrum of genetic disorders arising from structural or functional impairments of ...
Qiaowei Zhang, Shuwen Xue, Zhi Gao, Panlai Shi, Li Wang, Qi Feng, Xiangdong Kong, Xiaofan Zhu   +7 more
wiley   +1 more source

Focal segmental glomerulosclerosis, excluding atypical lesion, is a predictor of renal outcome in patients with membranous nephropathy: a retrospective analysis of 716 cases

BMC Nephrology, 2019
Background Focal segmental lesions (FSLs) are not uncommon in idiopathic membranous nephropathy (IMN). The reported percentage of IMN patients with focal segmental glomerulosclerosis (FSGS) lesions varies widely between studies.
Hong-Guang He, Chao-Qing Wu, Kun Ye, Chun Zeng, Yi-Yun Huang, Shu-Wen Luo, Wu Yin, Qiu-Rong Ye, Xiao-Mei Peng   +8 more
doaj   +1 more source

Advances in FGF/FGFR Signaling: Implications for Disease and Therapy

MedComm, Volume 7, Issue 9, September 2026.
The FGF/FGFR signaling is indispensable for the maintenance of physiological homeostasis and governs multiple biological processes, including embryonic development, bone metabolism, angiogenesis, and neurogenesis, whereas aberrant hyperactivation of this pathway drives the progression of malignancies and autoimmune disorders, including inflammatory ...
Miaoyu Song, Xi Liu, Yang Xiao, Yongsheng Li, Huakan Zhao   +4 more
wiley   +1 more source

Phenotypic and Genotypic Landscape of Sitosterolemia in China: Including a Rare Case With Nephronophthisis

Molecular Genetics &Genomic Medicine, Volume 14, Issue 9, September 2026.
This study describes the first reported case of concurrent sitosterolemia (STSL) and nephronophthisis (NPHP). Additionally, we provide a systematic review of the clinical and genetic characteristics of Chinese STSL patients, representing the largest comprehensive cohort in China to date.
Dan Ding, Hongmei Wu, Fei Zhao, Bixia Zheng, Qiuxia Chen   +4 more
wiley   +1 more source

When Hepatitis B Virus-Associated Glomerulonephritis Mimics Lupus Nephritis: A Case of Adult-Onset Disease With Full-House Pattern

Kidney Medicine
Although membranous nephritis represents the classic presentation of hepatitis B virus--associated glomerulonephritis (HBV-GN) in children, adult cases can exhibit quite different features.
Kei Kono, Naoki Sawa, Hiroki Mizuno, Yuki Oba, Noriko Inoue, Akinari Sekine, Kiho Tanaka, Masayuki Yamanouchi, Eiko Hasegawa, Tatsuya Suwabe, Satoshi Saitoh, Takeshi Fujii, Yutaka Takazawa, Kenichi Ohashi, Takehiko Wada, Yoshifumi Ubara   +15 more
doaj   +1 more source

A large, international study on post-transplant glomerular diseases: the TANGO project

BMC Nephrology, 2018
Background Long-term outcomes in kidney transplantation (KT) have not significantly improved during the past twenty years. Despite being a leading cause of graft failure, glomerular disease (GD) recurrence remains poorly understood, due to heterogeneity ...
Audrey Uffing, Maria José Pérez-Sáez, Gaetano La Manna, Giorgia Comai, Clara Fischman, Samira Farouk, Roberto Ceratti Manfro, Andrea Carla Bauer, Bruno Lichtenfels, Juliana B. Mansur, Hélio Tedesco-Silva, Gianna M. Kirsztajn, Anna Manonelles, Oriol Bestard, Miguel Carlos Riella, Silvia Regina Hokazono, Carlos Arias-Cabrales, Elias David-Neto, Carlucci Gualberto Ventura, Enver Akalin, Omar Mohammed, Eliyahu V. Khankin, Kassem Safa, Paolo Malvezzi, Michelle Marie O’Shaughnessy, Xingxing S. Cheng, Paolo Cravedi, Leonardo V. Riella   +27 more
doaj   +1 more source

A Rare Case of COPA Syndrome: Multisystem Relapse and Fatal Septic Complication

Respirology Case Reports, Volume 14, Issue 9, September 2026.
A 45‐year‐old man with a history of recurrent respiratory failure, arthritis and renal dysfunction was diagnosed with COPA syndrome through genetic testing after years of progressive interstitial lung disease and immune‐mediated manifestations. He initially responded to immunosuppressive therapy but relapsed after treatment discontinuation, developing ...
Flavia Castro Velasco Fernandes, Pedro Paulo Teixeira e Silva Torres, Elisângela de Paula Silveira‐Lacerda, Matheus Rabahi, Lucas Velasco Magalhaes Fernandes, Laís Rocha Lopes, Marise Amaral Rebouças Moreira, Marcelo Fouad Rabahi   +7 more
wiley   +1 more source

Targeted therapy in glomerular diseases

Journal of the Formosan Medical Association
Targeted therapy has emerged as a more precise approach to treat glomerular diseases, focusing on specific molecular or cellular processes that contribute to disease development or progression.
Yi-Chan Lin, Tyng-Shiuan Gau, Zheng-Hong Jiang, Kuan-Yu Chen, Yi-Ting Tsai, Kuan-Yu Lin, Hung-Ning Tung, Fan-Chi Chang   +7 more
doaj   +1 more source

Stage‐Specific H3K14 and H3K23 Succinylation Orchestrates Insect Metamorphosis and Oogenesis

Advanced Science, Volume 13, Issue 43, 3 August 2026.
Stage‐specific succinylation of histone H3 at lysine 14 and 23 differentially controls insect metamorphosis and oogenesis through distinct GPCR‐PKC signaling cascades, revealing an evolutionarily conserved epigenetic mechanism that coordinates key life‐history traits.
Yu‐Pu Jing, Lunjie Li, Libin Yang, Lin‐Jie Zhang, Qiang Yan, Ci Zhang, Zanrong Wen, Guangze Yu, Qian Li, Shutang Zhou   +9 more
wiley   +1 more source