Results 21 to 30 of about 25,279 (271)

Low dose of Rotigotine in post-stroke patients with vascular parkinsonism and obstructive sleep apnoea syndrome, effects on quality of life and rehabilitation therapy [PDF]

, 2017
Stroke is a frequent cause of disability in U.S.A. (200.000/ year). Aim: The aim of this study is to underline the effect of low dose of Rotigotine patches 2 mg/24 h, a complete dopamine agonist with continuous dopaminergic stimulation through the ...
Ceratti U, Dalmaso S, Fabrizio A, Maietta A, Marchitto N, Monaco P, Raimondi G, Sindona F   +7 more
core   +1 more source

Atypical parkinsonism – new advances

Current Opinion in Neurology, 2016
Purpose of review This update discusses novel aspects on genetics, pathophysiology and therapeutic approaches for atypical parkinsonism (progressive supranuclear palsy, corticobasal degeneration and multiple system atrophy) published in the last 2 years.
Stamelou, M., Bhatia, K.P.
openaire   +3 more sources

MRI Signs of Parkinson’s Disease and Atypical Parkinsonism [PDF]

RöFo - Fortschritte auf dem Gebiet der Röntgenstrahlen und der bildgebenden Verfahren, 2021
Background Diagnosis of Parkinson’s disease and atypical parkinsonism is based on clinical evaluation of the patient’s symptoms and on magnetic resonance imaging (MRI) of the brain, which can be supplemented by nuclear medicine techniques. MRI plays a leading role in the differentiation between Parkinson’s disease and atypical parkinsonism.
Schekeb, Aludin, Lars-Patrick Andreas, Schmill   +1 more
openaire   +2 more sources

Atypical parkinsonism-associated retromer mutant alters endosomal sorting of specific cargo proteins [PDF]

, 2016
The retromer complex acts as a scaffold for endosomal protein complexes that sort integral membrane proteins to various cellular destinations. The retromer complex is a heterotrimer of VPS29, VPS35, and VPS26.
Adam P. Jellett, Arighi, Balana, Bean, Bean, Brett M. Collins, Burd, Cai, Chan, Chapin, Chris M. Danson, Cullen, Damseh, Frances C. Tilley, Freeman, Gallon, Gomez, Gustavsson, Harbour, Harbour, Hesketh, Ian McGough, Joubert, Kate J. Heesom, Kerr, Kevin A. Wilkinson, Kirsty J. McMillan, Lauffer, MacLeod, Matthew Gallon, McGough, McGough, Muhammad, Peter J. Cullen, Phillips-Krawczak, Popoff, Rovelet-Lecrux, Seaman, Seaman, Seaman, Seaman, Shannon, Shi, Small, Steinberg, Steinberg, Temkin, Thomas Clairfeuille, Vardarajan, Vilariño-Güell, Vilariño-Güell, Wang, Yoshimura, Zavodszky, Zimprich   +54 more
core   +3 more sources

Clinical Application of Brain MRI in the Diagnostic Work-up of Parkinsonism

Journal of Parkinson’s Disease, 2017
Background: Differentiating Parkinson’s disease and atypical parkinsonism on clinical parameters is challenging, especially in early disease courses. This is due to large overlap in symptoms and because the so called red flags, i.e.
Frederick J.A. Meijer, Bozena Goraj, Bastiaan R. Bloem, Rianne A.J. Esselink   +3 more
doaj   +1 more source

Pain in neurodegenerative diseases with atypical parkinsonism: a systematic review on prevalence, clinical presentation, and findings from experimental studies

Journal of Integrative Neuroscience, 2021
Parkinson’s disease-related pain has increasingly been investigated in research studies. Still, only a few studies have addressed the prevalence and clinical characteristics of pain in neurodegenerative disorders with atypical parkinsonism.
Jerry Yi Chang, Katarina Rukavina, Timothy Lawn, K Ray Chaudhuri   +3 more
doaj   +1 more source

DJ-1 interacts with and regulates paraoxonase-2, an enzyme critical for neuronal survival in response to oxidative stress. [PDF]

, 2014
Loss-of-function mutations in DJ-1 (PARK7) gene account for about 1% of all familial Parkinson's disease (PD). While its physiological function(s) are not completely clear, DJ-1 protects neurons against oxidative stress in both in vitro and in vivo ...
Aleyasin, Hossein, Bourquard, Noam, Callaghan, Steve, Figeys, Daniel, Huang, En, Irrcher, Isabella, Kim, Raymond H, Mak, Tak W, Park, David S, Parsanejad, Mohammad, Qu, Dianbo, Reddy, Srinivasa T, Rousseaux, Maxime WC, Slack, Ruth S, Vaillant, Dominique C, Zhang, Yi   +15 more
core   +7 more sources

Medio-Lateral Balance Impairment Differentiates between Parkinson's Disease and Atypical Parkinsonism

Journal of Parkinson’s Disease, 2014
In early disease stages, it can be difficult to differentiate clinically between Parkinson's disease and the various forms of atypical parkinsonism, like multiple system atrophy or progressive supranuclear palsy.
Jorik Nonnekes, Marjolein B. Aerts, W.F. Abdo, Bastiaan R. Bloem   +3 more
doaj   +1 more source

Corticobasal syndrome in a man with Gaucher disease type 1: Expansion of the understanding of the neurological spectrum

Molecular Genetics and Metabolism Reports, 2018
Gaucher disease (GD) is an autosomal recessive condition that results from a deficiency of the enzyme β-glucocerebrosidase. The increased risk of primary parkinsonism symptoms among individuals affected with GD and carriers for the disorder is well ...
Kunal C. Potnis, Lauren B. Flueckinger, Stephanie M. DeArmey, Roy N. Alcalay, Jeffrey W. Cooney, Priya S. Kishnani   +5 more
doaj   +1 more source

Utility of the new Movement Disorder Society clinical diagnostic criteria for Parkinson's disease applied retrospectively in a large cohort study of recent onset cases [PDF]

, 2017
Objective: To examine the utility of the new Movement Disorder Society (MDS) diagnostic criteria in a large cohort of Parkinson's disease (PD) patients.
,, Bajaj, Nin, Barker, Roger A., Ben-Shlomo, Yoav, Burn, David J., Foltynie, Tom, Grosset, Donald G., Grosset, Katherine A., Hardy, John, Lawton, Michael A., Malek, Naveed, Morris, Huw R., Williams, Nigel M., Wood, Nicholas   +13 more
core   +5 more sources