Results 1 to 10 of about 8,070 (210)
Auranofin potentiates linezolid activity against MRSA by disrupting redox homeostasis and inhibiting SarA-mediated virulence and biofilm [PDF]
VirulenceMethicillin-resistant Staphylococcus aureus (MRSA) remains a major therapeutic challenge and poses a significant global health threat. Developing adjuvants to enhance the efficacy of existing antibiotics represents a promising strategy to address this ...
Jian-Guo Li +8 more
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Auranofin Ameliorates Gouty Inflammation by Suppressing NLRP3 Activation and Neutrophil Migration via the IL-33/ST2–CXCL1 Axis [PDF]
CellsGout is a form of sterile inflammatory arthritis in which monosodium urate (MSU) crystals deposit and provoke a neutrophil-predominant response, primarily driven by activation of the NACHT, leucine-rich repeat, and pyrin domain-containing protein 3 ...
Hyeyeon Yoo +7 more
doaj +2 more sources
Reactive oxygen species promotion drives auranofin’s antiviral activity against hepatitis E virus [PDF]
Journal of VirologyHepatitis E virus (HEV) causes roughly 20 million yearly global infections and is associated with chronic hepatitis, neurological sequelae, and pregnancy-related adverse outcomes that require antiviral intervention.
Kateland Tiller +5 more
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Comprehensive chemical proteomics for target deconvolution of the redox active drug auranofin
Redox Biology, 2020 Chemical proteomics encompasses novel drug target deconvolution methods in which compound modification is not required. Herein we use Thermal Proteome Profiling, Functional Identification of Target by Expression Proteomics and multiplexed redox ...
Amir Ata Saei +2 more
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Synthesis and in vitro characterization of [198Au]Auranofin [PDF]
EJNMMI Radiopharmacy and ChemistryBackground Radiopharmaceuticals offer targeted treatment by combining diagnostic or therapeutic radionuclides with biologically active molecules. Auranofin is the only Food and Drug Administration (FDA) approved gold(I) complex, originally developed for ...
Punita Bhardwaj +6 more
doaj +2 more sources
Ligand supplementation restores the cancer therapy efficacy of the antirheumatic drug auranofin from serum inactivation [PDF]
Nature CommunicationsAuranofin, an FDA-approved antirheumatic gold drug, has gained ongoing interest in clinical studies for treating advanced or recurrent tumors. However, gold ion’s dynamic thiol exchange nature strongly attenuates its bioactivity due to the fast formation
Yuan Wang +8 more
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Antileishmanial activity of auranofin against Leishmania major in vitro
International Archives of Health Sciences, 2022 Aim: Despite the various studies done in the field of cutaneous leishmaniasis treatment, there is still no perfect and safe drug for definite treatment of this disease. Therefore, the quest to find an appropriate drug continues.
Mohammad Ezati Mehmandust Olya +5 more
doaj +1 more source
Fisheries and Aquatic Sciences, 2023 Auranofin is a US Food and Drug Administration (FDA)-approved anti-arthritis medication that functions as a thioredoxin reductase inhibitor. Spermidine, a polyamine present in marine algae, can exert various physiological functions.
Hyun Hwangbo +7 more
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Molecules, 2022 Auranofin, as a thioredoxin reductase (TrxR) inhibitor, has promising anti-cancer activity in several cancer types. However, little is known about the inhibitory effect of auranofin on lung cancer cell growth.
Xia Ying Cui +2 more
doaj +1 more source
Scientific Reports, 2021 Bacterial infection of pressure ulcers (PUs) are a notable source of hospitalization for individuals with diabetes. This study evaluated the safety profile and efficacy of auranofin to treat diabetic PUs infected with methicillin-resistant Staphylococcus
Haroon Mohammad +4 more
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