Insulin autoantibodies as determined by competitive radiobinding assay are positively correlated with impaired beta-cell function — The Ulm-Frankfurt population study [PDF]
, 1991 Out of a random population of 4208 non-diabetic pupils without a family history of Type I diabetes 44 (1.05%) individuals had islet cell antibody (ICA) levels greater or equal to 5 Juvenile Diabetes Foundation (JDF) units. 39 of these ICA-positives could
N. Yassin I +14 more
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Immunologic Research, 2013 Autoimmune diseases (ADs) are chronic conditions initiated by the loss of immunological tolerance to self-antigens. The pathogenic hypothesis comprises a complex interaction between genetic, environmental and hormonal factors that interact with an individual over time generating a dysregulation of the immune system leading to disease development ...
PERRICONE, CARLO +5 more
openaire +3 more sources
Secretion of celiac disease autoantibodies after in vitro gliadin challenge is dependent on small-bowel mucosal transglutaminase 2-specific IgA deposits [PDF]
, 2008 Background: In celiac disease gluten, the disease-inducing toxic component in wheat, induces the secretion of autoantibodies which are targeted against transglutaminase 2 (TG2). These autoantibodies are produced in the small-intestinal mucosa, where they
Markku Maki +31 more
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Extrapancreatic autoantibody profiles in type I diabetes. [PDF]
PLoS ONE, 2012 Type I diabetes (T1D) is an autoimmune disease characterized by destruction of insulin-producing β-cells in the pancreas. Although several islet cell autoantigens are known, the breadth and spectrum of autoantibody targets has not been fully explored ...
Peter D Burbelo +9 more
doaj +1 more source
Autoantibody profiles in systemic sclerosis; a comparison of diagnostic tests
Autoimmunity, 2021 Objectives Autoimmune antibody profiling plays a prominent role in both classification and prognosis of systemic sclerosis (SSc). In the last years novel autoantibodies have been discovered and have become available in diagnostic assays.
Wynand Alkema +10 more
doaj +1 more source
Iranian Journal of Allergy, Asthma and Immunology, 2022 Expression and location of nucleolin are often abnormal in malignancies, which may result in the production of autoantibodies. Despite this, the identification of such autoantibodies may be essential for the early diagnosis and prognosis of cancers.
Fatemeh Ezzatifar +4 more
doaj +1 more source
Autoantibodies to insulin, insulinoma-associated antigen-2, and zinc transporter 8 improve the prediction of early insulin requirement in adult-onset autoimmune diabetes [PDF]
, 2010 Objective: The aim of this study was to indentify the predictive marker for early insulin requirement in adult-onset autoimmune diabetes in the Japanese populations.Design/Patients: We analyzed insulin autoantibodies (IAA), IA-2 autoantibodies (IA-2icA)
Eguchi, Katsumi +8 more
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Anticytokine Autoantibodies: Association with Infection and Immune Dysregulation
Antibodies, 2016 The association of autoantibodies to cytokines with immune deficiency, autoimmunity and/or immune dysregulation is increasingly being recognized. For example, autoantibodies to interferon gamma have been found to be associated with chronic, treatment ...
Vijaya Knight +2 more
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ESC Heart Failure, 2023 Aims A causal link between non‐ischaemic heart failure (HF) and humoral autoimmunity against G‐protein‐coupled receptors (GPCR) remains unclear except for Chagas' cardiomyopathy.
Elric Zweck +11 more
doaj +1 more source
Inflammatory bowel disease-specific autoantibodies in HLA-B27-associated spondyloarthropathies: Increased prevalence of ASCA and pANCA [PDF]
, 2004 Aims: An association between inflammatory bowel disease (IBD) and spondyloarthropathies (SpA) has repeatedly been reported. The aim of the present study was to investigate whether serologic markers of IBD, e. g.
Folwaczny, Christian +15 more
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