Results 1 to 10 of about 219,094 (347)

Enhanced treatment strategies and distinct disease outcomes among autoantibody-positive and -negative rheumatoid arthritis patients over 25 years: A longitudinal cohort study in the Netherlands.

PLoS Medicine, 2020
BackgroundBased on different genetic and environmental risk factors and histology, it has been proposed that rheumatoid arthritis (RA) consists of 2 types: autoantibody-positive and autoantibody-negative RA. However, until now, this remained hypothetical.
Xanthe M E Matthijssen, Ellis Niemantsverdriet, Tom W J Huizinga, Annette H M van der Helm-van Mil   +3 more
doaj   +2 more sources

Use of thymidine kinase 1 autoantibody, thymidine kinase antigen, extracellular protein kinase A autoantibody, and C‐reactive protein for early detection of malignant tumors in dogs [PDF]

Journal of Veterinary Internal Medicine
Background Although the importance of early diagnosis of malignant tumors is a major concern, an easily accessible in‐house method has not been established.
Yoonhee Kim, Wonhee Lee, Byunggak Kim, Bonghwan Jang, Kyung‐Rok Yu, Hong Sook Kim, Minok Ryu, Yein Oh, Kyoungwon Seo, Chul Park, Ulsoo Choi, Dongha Bhang, Hwayoung Youn   +12 more
doaj   +2 more sources

Islet autoantibodies as precision diagnostic tools to characterize heterogeneity in type 1 diabetes: a systematic review [PDF]

Communications Medicine
Background Islet autoantibodies form the foundation for type 1 diabetes (T1D) diagnosis and staging, but heterogeneity exists in T1D development and presentation.
Jamie L. Felton, Maria J. Redondo, Richard A. Oram, Cate Speake, S. Alice Long, Suna Onengut-Gumuscu, Stephen S. Rich, Gabriela S. F. Monaco, Arianna Harris-Kawano, Dianna Perez, Zeb Saeed, Benjamin Hoag, Rashmi Jain, Carmella Evans-Molina, Linda A. DiMeglio, Heba M. Ismail, Dana Dabelea, Randi K. Johnson, Marzhan Urazbayeva, John M. Wentworth, Kurt J. Griffin, Emily K. Sims, On behalf of the ADA/EASD PMDI   +22 more
doaj   +2 more sources

Prediction of impending type 1 diabetes through automated dual-label measurement of proinsulin:C-peptide ratio [PDF]

, 2016
Background : The hyperglycemic clamp test, the gold standard of beta cell function, predicts impending type 1 diabetes in islet autoantibody-positive individuals, but the latter may benefit from less invasive function tests such as the proinsulin: C ...
Annelien Van Dalem, Bart Keymeulen, Belgian Diabetes Registry, Bruno Lapauw, Christophe De Block, Daniël Pipeleers, Eric V Balti, Eric Weber, Frans K Gorus, Ilse Vermeulen, Ilse Weets, Pascale Abrams, Pieter De Pauw, Pieter Gillard, Simke Demeester   +14 more
core   +18 more sources

Positive Predictive Value of Myelin Oligodendrocyte Glycoprotein Autoantibody Testing

JAMA Neurology, 2021
Key Points Question What is the positive predictive value of myelin oligodendrocyte glycoprotein (MOG)–IgG1 testing in a clinical setting? Findings Of 1260 consecutive patients tested for MOG-IgG1 at the Mayo Clinic over 2 years, 92 (7.3%) were positive,
E. Sechi, Marina Buciuc, S. Pittock, John J. Chen, J. Fryer, S. Jenkins, A. Budhram, B. Weinshenker, A. S. Lopez-Chiriboga, J. Tillema, A. McKeon, J. Mills, W. Tobin, E. Flanagan   +13 more
semanticscholar   +1 more source

Autoantibody-Specific Signalling in Pemphigus

Frontiers in Medicine, 2021
Pemphigus is a severe autoimmune disease impairing barrier functions of epidermis and mucosa. Autoantibodies primarily target the desmosomal adhesion molecules desmoglein (Dsg) 1 and Dsg 3 and induce loss of desmosomal adhesion.
T. Schmitt, J. Waschke
semanticscholar   +1 more source

Anti-Myxovirus Resistance Protein-1 Immunoglobulin A Autoantibody in Idiopathic Pulmonary Fibrosis

Canadian Respiratory Journal, 2022
Background. We have previously analysed serum autoantibody levels in patients with idiopathic pulmonary fibrosis (IPF), idiopathic nonspecific interstitial pneumonia (iNSIP), and healthy controls and identified the autoantibody against anti-myxovirus ...
Toru Arai, Masaki Hirose, Yoshimasa Hamano, Tomoko Kagawa, Akihiro Murakami, Hiroshi Kida, Atsushi Kumanogoh, Yoshikazu Inoue   +7 more
doaj   +1 more source

Effectiveness of pirfenidone in idiopathic pulmonary fibrosis according to the autoantibody status: a retrospective cohort study

BMC Pulmonary Medicine, 2021
Background Pirfenidone is an anti-fibrotic agent shown to slow the progression of idiopathic pulmonary fibrosis (IPF). However, its effectiveness in association with serological autoimmune features in IPF remains unclear.
Myung Jin Song, Sang Hoon Lee, Ji Ye Jung, Young Ae Kang, Moo Suk Park, Young Sam Kim, Joon Chang, Song Yee Kim   +7 more
doaj   +1 more source

Comprehensive autoantibody profiling in systemic autoimmunity by a highly-sensitive multiplex protein array

Frontiers in Immunology, 2023
Comprehensive autoantibody evaluation is essential for the management of autoimmune disorders. However, conventional methods suffer from poor sensitivity, low throughput, or limited availability.
Ai Kuzumi, Yuta Norimatsu, Kazuki M. Matsuda, Chihiro Ono, Taishi Okumura, Emi Kogo, Naoki Goshima, Naoki Goshima, Takemichi Fukasawa, Takemichi Fukasawa, Natsumi Fushida, Motoki Horii, Takashi Yamashita, Asako Yoshizaki-Ogawa, Kei Yamaguchi, Kei Yamaguchi, Takashi Matsushita, Shinichi Sato, Ayumi Yoshizaki, Ayumi Yoshizaki   +19 more
doaj   +1 more source

A Mathematical Model of Thyroid Disease Response to Radiotherapy [PDF]

Mathematics 2021, 9(19), 2365, 2021
We present a mechanistic biomathematical model of molecular radiotherapy of thyroid disease. The general model consists of a set of differential equations describing the dynamics of different populations of thyroid cells with varying degrees of damage caused by radiotherapy (undamaged cells, sub-lethally damaged cells, doomed cells, and dead cells), as
arxiv   +1 more source