Results 91 to 100 of about 228,187 (396)

Autoantibody-producing plasmablasts after B cell depletion identified in muscle-specific kinase myasthenia gravis.

JCI Insight, 2017
Myasthenia gravis (MG) is a B cell-mediated autoimmune disorder of neuromuscular transmission. Pathogenic autoantibodies to muscle-specific tyrosine kinase (MuSK) can be found in patients with MG who do not have detectable antibodies to the acetylcholine
P. Stathopoulos, Aditya Kumar, R. Nowak, K. O’Connor   +3 more
semanticscholar   +1 more source

Cell Membrane‐Coated Lipid Nanoparticles for Drug Delivery

Aggregate, EarlyView.
This review highlights recent progress in cell membrane‐coated lipid nanoparticles (CMC‐LNPs), focusing on their design, preparation methods, functional integration, and biomedical applications. It discusses various types of LNPs and coating strategies, characterization techniques, therapeutic functions, and applications.
Moataz B. Zewail, Guangze Yang, Yilong Fan, Yue Hui, Chun‐Xia Zhao, Yun Liu   +5 more
wiley   +1 more source

Islet autoantibody positivity in overweight and obese adults with type 2 diabetes

Autoimmunity, 2018
Islet autoantibodies are typically associated with type 1 diabetes, but have been found in patients diagnosed with type 2 diabetes in whom they are associated with lower adiposity.
Scott J. Pilla, Ashok Balasubramanyam, William C. Knowler, Mariana Lazo, David M. Nathan, Xavier Pi-Sunyer, Jeanne M. Clark, Nisa M. Maruthur, The Look AHEAD Research Group   +8 more
doaj   +1 more source

Identification and Validation of Novel Serum Autoantibodies Biomarkers for Staging Liver Fibrosis in Patients With Chronic Hepatitis B

Frontiers in Medicine, 2022
Aim: Liver fibrosis monitoring is essential in patients with chronic hepatitis B (CHB). However, less robust, noninvasive diagnostic methods for staging liver fibrosis, other than liver biopsy, are available.
Saiping Qi, Jing Li, Xiaomin He, Jialing Zhou, Jialing Zhou, Zhibin Chen, Xiaojin Li, Bei Zhang, Hong Ma, Hong You, Hong You, Hong You, Jian Huang   +12 more
doaj   +1 more source

Capillary blood islet autoantibody screening for identifying pre-type 1 diabetes in the general population: design and initial results of the Fr1da study

BMJ Open, 2016
Introduction Type 1 diabetes can be diagnosed at an early presymptomatic stage by the detection of islet autoantibodies. The Fr1da study aims to assess whether early staging of type 1 diabetes (1) is feasible at a population-based level, (2) prevents ...
J. Raab, F. Haupt, Marlon Scholz, Claudia Matzke, K. Warncke, K. Lange, R. Assfalg, Katharina Weininger, Susanne Wittich, Stephanie Löbner, A. Beyerlein, U. Nennstiel-Ratzel, M. Lang, O. Laub, D. Dunstheimer, E. Bonifacio, P. Achenbach, C. Winkler, A. Ziegler   +18 more
semanticscholar   +1 more source

A replication study confirms the association of TNFSF4 (OX40L) polymorphisms with systemic sclerosis in a large European cohort [PDF]

, 2010
<p><b>Objectives</b> The aim of this study was to confirm the influence of TNFSF4 polymorphisms on systemic sclerosis (SSc) susceptibility and phenotypic features.</p> <p><b>Methods</b> A total of 8 European ...
A E Voskuyl, A Fernández-Nebro, A Herrick, A J Schuerwegh, A Kreuter, A Nordin, A Pros, B A Lie, B P Koeleman, B Rueda, C Denton, C Fonseca, C P Simeon, C Tolosa, E De Langhe, E Vicente-Rabaneda, F De Keyser, F Houssiau, F J García-Hernández, G Espinosa, G Riemekasten, H Manku, I Castellví, I Gómez-Gracia, J A Román-Ivorra, J M van Laar, J Martín, J Worthington, JCA Broen, K Claes, L Beretta, L Bossini-Castillo, L Padykov, L Rodríguez, M A González-Gay, M C Vonk, M F González-Escribano, M Gallego, M M Chee, M T Camps, M V Egurbide, MJ Gough, MJH Coenen, N Hunzelmann, N Navarrete, N Ortego-Centeno, P Airó, P Carreira, P García de la Peña, P Gourh, P Shiels, R Hesselstrand, R Madhok, R Scorza, R Westhovens, T Witte, TRDJ Radstake, V Follonosa, V Smith, Ø Palm   +59 more
core   +5 more sources

Mixed Autoimmune Hemolytic Anemia: A Systematic Review of Epidemiology, Clinical Characteristics, Therapies, and Outcomes

American Journal of Hematology, EarlyView.
Mixed autoimmune hemolytic anemia (AIHA) is a rare condition characterized by the presence of both warm and cold autoantibodies, often leading to severe, treatment‐resistant hemolysis. In this systematic review of 81 patients across 35 studies, the median age was 45 years with a notable female predominance.
Jeremy W. Jacobs, Sheharyar Raza, Landon M. Clark, Laura D. Stephens, Elizabeth S. Allen, Jennifer S. Woo, Rachel Lane Walden, Cristina A. Figueroa Villalba, Christopher A. Tormey, Caroline G. Stanek, Brian D. Adkins, Evan M. Bloch, Garrett S. Booth   +12 more
wiley   +1 more source

Glial cells and neurologic autoimmune disorders

Frontiers in Cellular Neuroscience, 2022
Neurologic autoimmune disorders affect people’s physical and mental health seriously. Glial cells, as an important part of the nervous system, play a vital role in the occurrence of neurologic autoimmune disorders.
Zhao-Qing Li, Tong-Xin Li, Miao Tian, Ze-Sheng Ren, Chen-Yi Yuan, Rui-Kun Yang, Su-Juan Shi, Hui Li, Zhen-Zhen Kou   +8 more
doaj   +1 more source

Hereditary Multiple Osteochondromas and Acute Lymphoblastic Leukemia: A Possible Role for EXT1 and EXT2 in Hematopoietic Malignancies

American Journal of Medical Genetics Part A, Volume 197, Issue 7, July 2025.
ABSTRACT Hereditary multiple osteochondromas (HMO) is an autosomal dominant disorder caused by heterozygous deleterious variants in the EXT1 or EXT2 genes. While the clinical core phenotype is well established and mainly consists of bone deformities, limb length discrepancies, multiple benign bone neoplasms, and increased risk of chondrosarcoma, the ...
Francesco Comisi, Carmela Fusco, Rosamaria Mura, Carla Cerruto, Leonardo D'Agruma, Salvatore Carnazzo, Marco Castori, Salvatore Savasta   +7 more
wiley   +1 more source

AASLD practice guidance on drug, herbal, and dietary supplement–induced liver injury

, 2022
Hepatology, EarlyView.
Robert J. Fontana, Iris Liou, Adrian Reuben, Ayako Suzuki, M. Isabel Fiel, William Lee, Victor Navarro   +6 more
wiley   +1 more source