Results 91 to 100 of about 92,398 (247)

Expert Perspective: Diagnosis and Treatment of Castleman Disease

Arthritis &Rheumatology, EarlyView.
Castleman disease (CD) is a major diagnostic challenge for rheumatologists. Unicentric CD (UCD) involves one enlarged lymph node region, whereas multicentric CD (MCD) involves multiple enlarged lymph node regions. Both UCD and MCD may exhibit a wide range of symptoms that overlap with other immune‐mediated conditions.
Luke Y. C. Chen, Lu Zhang, David C. Fajgenbaum   +2 more
wiley   +1 more source

Genetically determined aberrant down-regulation of FcγRIIB1 in germinal center B cells associated with hyper-IgG and IgG autoantibodies in murine systemic lupus erythematosus [PDF]

, 1999
Yi Jiang, Sachiko Hirose, Reiko Sanokawa‐Akakura, Masaaki Abe, Xiaoyi Mi, Na Li, Yuko Miura, Jun Shirai, Danqing Zhang, Yoshitomo Hamano, Toshikazu Shirai   +10 more
openalex   +1 more source

Loss of Tripartite Motif–Containing Protein 21 and UVB‐Induced Systemic Inflammation by Regulating DNA‐Sensing Pathways

Arthritis &Rheumatology, EarlyView.
Objective Patients with systemic lupus erythematosus (SLE) experience photosensitivity, with exposure to UVB light driving lupus flares and triggering symptoms like joint pain, fatigue, and cutaneous lesions. Although the mechanism(s) linking UVB exposure to systemic effects are unclear, type I interferons (IFNs) are known to play a role.
Gantsetseg Tumurkhuu, Graziela Perri, Richard Moore, Lihong Huo, Arati Naveen Kumar, Richard Ainsworth, Trinitee Oliver, Gabriela De Los Santos, David Gibb, Jessica Carriere, Jeong Min Yu, Rachel Abuav, Lindsy Forbess, Daniel J. Wallace, Mariko Ishimori, Wonwoo Shon, Christian Stehlik, Caroline A. Jefferies   +17 more
wiley   +1 more source

Chimeric autoantibody receptor T cells specifically eliminate Graves’ Disease autoreactive B cells

Frontiers in Immunology
IntroductionChimeric antigen receptor (CAR) T cells have recently become an important treatment for hematological cancers by efficiently eliminating B cells.
Abigail Cheever, Hunter G. Lindsay, Chloe C. Kang, Mackenzie Hansen, Kimball Demars, Kim L. O’Neill, K. Scott Weber   +6 more
doaj   +1 more source

A Tolerogenic Plasmid Inhibits Autoantibody Production Triggered by Immunization With Human Peptidyl Arginine Deiminase 4

Arthritis &Rheumatology, EarlyView.
Objective Rheumatoid arthritis (RA) is usually preceded and likely mediated by autoantibodies to citrullinated proteins (ACPAs) that recognize citrulline residues on multiple proteins. Conversion of arginine into citrulline is performed by enzymes called peptidyl arginine deiminases (PADs). We have previously demonstrated that the human PAD4 (hPAD4) is
Philippe P. Pagni, Vijetha Kumar, Nathalie C. Lambert, Eva Frison, Herve Luche, Marielle Mello, Magali Torres, Johnna D. Wesley, Matthias von Herrath, Jean Roudier, Isabelle Auger   +10 more
wiley   +1 more source

Plasma IgG and IgM autoantibodies to COPT1 as potential biomarkers for detection of non-small cell lung cancer

Frontiers in Immunology
BackgroundEarly diagnosis of lung cancer is crucial for improving patient outcomes. Autoantibodies against tumor-associated antigens (TAAs) found in the plasma can serve as biomarkers for lung cancer detection.
Xiaobin Cao, Xiaobin Cao, Jing Li, Siyu Liu, Siyu Liu, Aichen Liu, Lulu Zhang, Fengqi Chen, Yutong Li, Yutong Li, Hanke Ma, Wenke Sun, Songyun Ouyang, Liping Dai, Jingjing Liu   +14 more
doaj   +1 more source

AB0607 MYOSITIS-RELATED INTERSTITIAL LUNG DISEASES: CLINICAL FEATURES, BIOMARKERS AND AUTOANTIBODIES IN LATINOAMERICAN PATIENTS [PDF]

, 2020
S. M. Sánchez Romo, Guiomar Mendieta, Miguel Ángel Villarreal‐Alarcón, I. D. J. Hernandez-Galarza, D. Á. Galarza-Delgado   +4 more
openalex   +1 more source

Pregnancy Outcomes in Women With Systemic Sclerosis Before and/or After Diagnosis and by Parity: A Swedish Population‐Based Cohort Study

Arthritis &Rheumatology, EarlyView.
Objective To assess risks of adverse pregnancy outcomes (APOs) in a contemporary cohort of women with systemic sclerosis (SSc) in relation to the timing of SSc diagnosis and by parity. Methods From the nationwide Swedish Medical Birth Register, we assembled pregnancies with births in women with SSc and in comparator women from the general population ...
Weng Ian Che, Luigi Annicchiarico, Laura Andreoli, Olof Stephansson, Marie Holmqvist, Karin Hellgren   +5 more
wiley   +1 more source

Clinical Significance of Anti‐Histidyl‐tRNA Synthetase (Jo1) Autoantibodies [PDF]

, 2007
E. Gomard-Mennesson, Nicole Fabien, Jean-François Cordier, J. Ninet, Jacques Tébib, H Rousset   +5 more
openalex   +1 more source

Autoantibody Response Toward Chromatin in Patients With Juvenile Idiopathic Arthritis

Arthritis &Rheumatology, EarlyView.
Objective Patients with juvenile idiopathic arthritis (JIA) frequently exhibit antinuclear antibodies (ANAs), but the specific antigen target recognized by them and the presence of additional autoantibody specificities in patients with JIA remains elusive.
Viola Pitkänen, Terhi Remes‐Pakarinen, Paula Vähäsalo, Milja Möttönen, Minna‐Maija Grönlund, Miika Arvonen, Mikael Knip, Riitta Veijola, Jorma Toppari, Jorma Ilonen, Johanna Lempainen, Anna‐Mari Schroderus, Liisa Kröger, Tuure Kinnunen   +13 more
wiley   +1 more source