Results 11 to 20 of about 235,603 (337)

Enhanced treatment strategies and distinct disease outcomes among autoantibody-positive and -negative rheumatoid arthritis patients over 25 years: A longitudinal cohort study in the Netherlands.

PLoS Medicine, 2020
BackgroundBased on different genetic and environmental risk factors and histology, it has been proposed that rheumatoid arthritis (RA) consists of 2 types: autoantibody-positive and autoantibody-negative RA. However, until now, this remained hypothetical.
Xanthe M E Matthijssen, Ellis Niemantsverdriet, Tom W J Huizinga, Annette H M van der Helm-van Mil   +3 more
doaj   +2 more sources

Positive Predictive Value of Myelin Oligodendrocyte Glycoprotein Autoantibody Testing

JAMA Neurology, 2021
Key Points Question What is the positive predictive value of myelin oligodendrocyte glycoprotein (MOG)–IgG1 testing in a clinical setting? Findings Of 1260 consecutive patients tested for MOG-IgG1 at the Mayo Clinic over 2 years, 92 (7.3%) were positive,
E. Sechi, Marina Buciuc, S. Pittock, John J. Chen, J. Fryer, S. Jenkins, A. Budhram, B. Weinshenker, A. S. Lopez-Chiriboga, J. Tillema, A. McKeon, J. Mills, W. Tobin, E. Flanagan   +13 more
semanticscholar   +1 more source

Autoantibody-Specific Signalling in Pemphigus

Frontiers in Medicine, 2021
Pemphigus is a severe autoimmune disease impairing barrier functions of epidermis and mucosa. Autoantibodies primarily target the desmosomal adhesion molecules desmoglein (Dsg) 1 and Dsg 3 and induce loss of desmosomal adhesion.
T. Schmitt, J. Waschke
semanticscholar   +1 more source

Autoantibody Specificities in Myasthenia Gravis; Implications for Improved Diagnostics and Therapeutics

Frontiers in Immunology, 2020
Myasthenia gravis (MG) is an autoimmune disease characterized by muscle weakness and fatiguability of skeletal muscles. It is an antibody-mediated disease, caused by autoantibodies targeting neuromuscular junction proteins.
K. Lazaridis, S. Tzartos
semanticscholar   +1 more source

The reliability of immunoassays to detect autoantibodies in patients with myositis is dependent on autoantibody specificity

Rheumatology, 2020
Objectives In order to address the reliability of commercial assays to identify myositis-specific and -associated autoantibodies, we aimed to compare the results of two commercial immunoassays with the results obtained by protein immunoprecipitation ...
S. Tansley, Danyang Li, Z. Betteridge, N. McHugh   +3 more
semanticscholar   +1 more source

Myasthenia Gravis: Autoantibody Specificities and Their Role in MG Management

Frontiers in Neurology, 2020
Myasthenia gravis (MG) is the most common autoimmune disorder affecting the neuromuscular junction, characterized by skeletal muscle weakness and fatigability.
K. Lazaridis, S. Tzartos
semanticscholar   +1 more source

Comparison of clinical and laboratory characteristics in children with type 1 diabetes according to pancreatic autoantibodies [PDF]

Korean Journal of Pediatrics, 2010
Purpose:The purpose of this study was to determine whether there is any difference in the clinical and laboratory characteristics of patients with autoantibody-positive and patients with autoantibody-negative type 1 diabetes at initial presentation ...
Ji Hae Choi, Min Sun Kim, Chan Jong Kim, Jong Duk Kim, Dae-Yeol Lee   +4 more
doaj   +1 more source

Prevalence and Outcome of Serum Autoantibodies in Chronic Hepatitis C Patients Undergoing Direct-Acting Antiviral Treatment

Frontiers in Immunology, 2022
BackgroundChronic immune stimulation by hepatitis C virus (HCV) may cause occurrence of several autoantibodies in infected patients, with or without features of clinically overt autoimmune diseases.
Ciro Romano, Olga Tortorella, Liliana Dalla Mora, Dario Di Stasio, Ausilia Sellitto, Luigi Elio Adinolfi, Aldo Marrone   +6 more
doaj   +1 more source

Screening for type 1 diabetes-, thyroid-, gastric-, and adrenal-specific humoral autoimmunity in 529 children and adolescents with celiac disease at diagnosis identifies as positive one in every nine patients [PDF]

, 2016
No abstract ...
Anania, Caterina, Cucchiara, Salvatore, Lenzi, Andrea, Montuori, Monica, Morano, Susanna, Panimolle, Francesca, Tiberti, Claudio, Trovato, CHIARA MARIA, Valitutti, Francesco, Vestri, Anna Rita   +9 more
core   +1 more source

Hierarchical Order of Distinct Autoantibody Spreading and Progression to Type 1 Diabetes in the TEDDY Study

Diabetes Care, 2020
OBJECTIVE The first-appearing β-cell autoantibody has been shown to influence risk of type 1 diabetes (T1D). Here, we assessed the risk of autoantibody spreading to the second-appearing autoantibody and further progression to clinical disease in The ...
Kendra Vehik, E. Bonifacio, Å. Lernmark, Liping Yu, A. Williams, D. Schatz, M. Rewers, J. She, J. Toppari, W. Hagopian, B. Akolkar, A. Ziegler, J. Krischer   +12 more
semanticscholar   +1 more source