Results 21 to 30 of about 228,187 (396)

Correlates of survival after autoantibody reduction therapy for acute IPF exacerbations.

open access: yesPLoS ONE, 2021
BackgroundNo medical treatment has proven efficacy for acute exacerbations of idiopathic pulmonary fibrosis (AE-IPF), and this syndrome has a very high mortality.
Tejaswini Kulkarni   +10 more
doaj   +1 more source

The reliability of immunoassays to detect autoantibodies in patients with myositis is dependent on autoantibody specificity

open access: yesRheumatology, 2020
Objectives In order to address the reliability of commercial assays to identify myositis-specific and -associated autoantibodies, we aimed to compare the results of two commercial immunoassays with the results obtained by protein immunoprecipitation ...
S. Tansley   +3 more
semanticscholar   +1 more source

Myasthenia Gravis: Autoantibody Specificities and Their Role in MG Management

open access: yesFrontiers in Neurology, 2020
Myasthenia gravis (MG) is the most common autoimmune disorder affecting the neuromuscular junction, characterized by skeletal muscle weakness and fatigability.
K. Lazaridis, S. Tzartos
semanticscholar   +1 more source

Comparison of clinical and laboratory characteristics in children with type 1 diabetes according to pancreatic autoantibodies [PDF]

open access: yesKorean Journal of Pediatrics, 2010
Purpose:The purpose of this study was to determine whether there is any difference in the clinical and laboratory characteristics of patients with autoantibody-positive and patients with autoantibody-negative type 1 diabetes at initial presentation ...
Ji Hae Choi   +4 more
doaj   +1 more source

Use of two methods to elute anti-IgG and anti-(IgG + C3d) type autoantibody from sensitized erythrocytes

open access: yesGlobal Journal of Transfusion Medicine, 2018
Background: Autoimmune hemolytic anemia (AIHA) is an immunological disease caused by autoantibodies. Warm autoantibody mainly includes anti-IgG and anti-(IgG+C3d) type, which can cause direct antiglobulin test (DAT) positive.
He Ziyi, Hu Yingming, Cui Siping
doaj   +1 more source

Autoantibody of NRIP, a novel AChR‐interacting protein, plays a detrimental role in myasthenia gravis

open access: yesJournal of Cachexia, Sarcopenia and Muscle, 2021
Background Nuclear receptor interaction protein (NRIP) co‐localizes with acetylcholine receptor (AChR) at the neuromuscular junction (NMJ), and NRIP deficiency causes aberrant NMJ architecture.
Li‐Kai Tsai   +10 more
doaj   +1 more source

Autoantibody Discovery, Assay Development and Adoption: Death Valley, the Sea of Survival and Beyond

open access: yesFrontiers in Immunology, 2021
Dating to the discovery of the Lupus Erythematosus (LE) cell in 1948, there has been a dramatic growth in the discovery of unique autoantibodies and their cognate targets, all of which has led to the availability and use of autoantibody testing for a ...
Marvin J. Fritzler   +3 more
doaj   +1 more source

Different Hierarchies of Anti–Modified Protein Autoantibody Reactivities in Rheumatoid Arthritis

open access: yesArthritis & Rheumatology, 2020
Anti–citrullinated protein antibodies (ACPAs) are a hallmark of seropositive rheumatoid arthritis (RA). Yet, the precise disease‐relevant autoantigens that are targeted by ACPAs remains a matter of debate.
P. Sahlström   +15 more
semanticscholar   +1 more source

Hierarchical Order of Distinct Autoantibody Spreading and Progression to Type 1 Diabetes in the TEDDY Study

open access: yesDiabetes Care, 2020
OBJECTIVE The first-appearing β-cell autoantibody has been shown to influence risk of type 1 diabetes (T1D). Here, we assessed the risk of autoantibody spreading to the second-appearing autoantibody and further progression to clinical disease in The ...
Kendra Vehik   +12 more
semanticscholar   +1 more source

Pathways Responsible for Human Autoantibody and Therapeutic Intravenous IgG Activity in Humanized Mice

open access: yesCell Reports, 2015
Immunoglobulin G (IgG) antibodies are major drivers of autoimmune pathology, but they are also used in the form of intravenous IgG (IVIg) therapy to suppress autoantibody activity. To identify the pathways underlying human autoantibody and IVIg activity,
Inessa Schwab, Anja Lux, Falk Nimmerjahn
doaj   +1 more source

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