Results 31 to 40 of about 137,428 (335)

Systemic translocation of Staphylococcus drives autoantibody production in HIV disease

Microbiome, 2019
Background Increased autoreactive antibodies have been reported in HIV disease; however, the mechanism accounting for autoantibody induction in HIV remains unknown.
Zhenwu Luo, Min Li, Yongxia Wu, Zhefeng Meng, Lisa Martin, Lumin Zhang, Elizabeth Ogunrinde, Zejun Zhou, Shenghui Qin, Zhuang Wan, Maria Anna Julia Westerink, Stephanie Warth, Hui Liu, Ping Jin, David Stroncek, Quan-Zhen Li, Ena Wang, Xueling Wu, Sonya L. Heath, Zihai Li, Alexander V. Alekseyenko, Wei Jiang   +21 more
doaj   +1 more source

Genome-Wide Assessment of Differential DNA Methylation Associated with Autoantibody Production in Systemic Lupus Erythematosus. [PDF]

PLoS ONE, 2015
Systemic lupus erythematosus (SLE) is characterized by the development of autoantibodies associated with specific clinical manifestations. Previous studies have shown an association between differential DNA methylation and SLE susceptibility, but have ...
Sharon A Chung, Joanne Nititham, Emon Elboudwarej, Hong L Quach, Kimberly E Taylor, Lisa F Barcellos, Lindsey A Criswell   +6 more
doaj   +1 more source

Autoreactive B cells recruited to lungs by silica exposure contribute to local autoantibody production in autoimmune-prone BXSB and B cell receptor transgenic mice

Frontiers in Immunology, 2022
Occupational exposure to inhaled crystalline silica dust (cSiO2) is linked to systemic lupus erythematosus, rheumatoid arthritis, systemic sclerosis, and anti-neutrophil cytoplasmic autoantibody vasculitis.
Lanette Fee, Lanette Fee, Advika Kumar, Robert M. Tighe, Robert M. Tighe, Mary H. Foster, Mary H. Foster   +6 more
doaj   +1 more source

A Toll for lupus [PDF]

, 2005
Toll-like receptor (TLR)-9 recognizes CpG motifs in microbial DNA. TLR9 signalling stimulates innate antimicrobial immunity and modulates adaptive immune responses including autoimmunity against chromatin, e.g., in systemic lupus erythematosus (SLE ...
Anders HJ, H-J Anders, Stacey KJ
core   +1 more source

A case-control study of rheumatoid arthritis identifies an associated single nucleotide polymorphism in the NCF4 gene, supporting a role for the NADPH-oxidase complex in autoimmunity [PDF]

, 2007
Rheumatoid arthritis (RA) is a chronic inflammatory disease with a heritability of 60%. Genetic contributions to RA are made by multiple genes, but only a few gene associations have yet been confirmed.
Alfredsson, L, Burkhardt, H, Holmdahl, Rikard,, Kallberg, H, Klareskog, L, Lindqvist, Anna-Karin,, Lund University., Olsson, Lina,, Padyukov, L   +8 more
core   +2 more sources

Successful treatment of autoimmunity in NZB/NZW F1 mice with monoclonal antibody to L3T4. [PDF]

, 1985
Autoimmune NZB/NZW mice were treated with weekly injections of monoclonal antibody (mAb) to L3T4, an antigen expressed on a distinct subpopulation of T cells that respond to class II major histocompatibility antigens.
Seaman, WE, Wofsy, D
core   +1 more source

DPVis: Visual Analytics with Hidden Markov Models for Disease Progression Pathways

, 2020
Clinical researchers use disease progression models to understand patient status and characterize progression patterns from longitudinal health records.
Anand, Vibha, Frohnert, Brigitte I, Ghosh, Soumya, Kwon, Bum Chul, Lundgren, Markus, Ng, Kenney, Severson, Kristen A, Sun, Zhaonan   +7 more
core   +1 more source

Proinsulin Secretion Is a Persistent Feature of Type 1 Diabetes [PDF]

, 2019
OBJECTIVE: Abnormally elevated proinsulin secretion has been reported in type 2 and early type 1 diabetes when significant C-peptide is present. We questioned whether individuals with long-standing type 1 diabetes and low or absent C-peptide secretory
Arvan, Peter, Bahnson, Henry T., Blum, Janice, Considine, Robert V., Davis, Asa K., DiMeglio, Linda A., Evans-Molina, Carmella, Greenbaum, Carla J., Haataja, Leena, Marcovina, Santica, Mastracci, Teresa L., Mirmira, Raghavendra G., Morris, Margaret A., Nadler, Jerry, Nyalwidhe, Julius, Qian, Wei-Jun, Schmidt, C. Max, Sims, Emily K., Speake, Cate, Swensen, Adam C., T1D Exchange Residual C-peptide Study Group, Yi, Lian, Yip-Schneider, Michele   +22 more
core   +1 more source

Anti-BIRC5 autoantibody serves as a valuable biomarker for diagnosing AFP-negative hepatocellular carcinoma [PDF]

PeerJ
Background Autoantibodies targeting tumor-associated antigens (TAAbs) have emerged as promising biomarkers for early cancer detection. This research aimed to assess the diagnostic capacity of anti-BIRC5 autoantibody in detecting AFP-negative ...
Qing Li, Haiyan Liu, Han Wang, Wenzhuo Xiong, Liping Dai, Xiuzhi Zhang, Peng Wang, Hua Ye, Jianxiang Shi, Zhihao Fang, Keyan Wang   +10 more
doaj   +2 more sources

Altered Tim-1 and IL-10 Expression in Regulatory B Cell Subsets in Type 1 Diabetes

Frontiers in Immunology, 2021
BackgroundType 1 diabetes (T1D) is an autoimmune disease with a complex aetiology. B cells play an important role in the pathogenesis of T1D. Regulatory B cells (Bregs) are a subset of B cells that produce and secrete the inhibitory factor interleukin-10
Yikai Liu, Zhiying Chen, Junlin Qiu, Hongzhi Chen, Zhiguang Zhou   +4 more
doaj   +1 more source