Results 31 to 40 of about 219,094 (347)

Mechanisms of Autoantibody-Induced Pathology

Frontiers in Immunology, 2017
Autoantibodies are frequently observed in healthy individuals. In a minority of these individuals, they lead to manifestation of autoimmune diseases, such as rheumatoid arthritis or Graves’ disease.
R. Ludwig, K. Vanhoorelbeke, F. Leypoldt, Z. Kaya, K. Bieber, S. McLachlan, L. Komorowski, Jie Luo, O. Cabral-Marques, C. Hammers, J. Lindstrom, P. Lamprecht, A. Fischer, G. Riemekasten, C. Tersteeg, P. Sondermann, B. Rapoport, K. Wandinger, C. Probst, Asmaa El Beidaq, E. Schmidt, Alan Verkman, R. Manz, F. Nimmerjahn   +23 more
semanticscholar   +1 more source

Pathways Responsible for Human Autoantibody and Therapeutic Intravenous IgG Activity in Humanized Mice

Cell Reports, 2015
Immunoglobulin G (IgG) antibodies are major drivers of autoimmune pathology, but they are also used in the form of intravenous IgG (IVIg) therapy to suppress autoantibody activity. To identify the pathways underlying human autoantibody and IVIg activity,
Inessa Schwab, Anja Lux, Falk Nimmerjahn
doaj   +1 more source

Pathogenetic insights from the treatment of rheumatoid arthritis [PDF]

, 2017
Rheumatoid arthritis is a chronic autoimmune disease that causes progressive articular damage, functional loss, and comorbidity. The development of effective biologics and small-molecule kinase inhibitors in the past two decades has substantially ...
McInnes, Iain B., Schett, Georg
core   +1 more source

The Relationship between Serum Carbonic Anhydrase I-II Autoantibody Levels and Diabetic Retinopathy in Type 1 Diabetes Patients

Türk Oftalmoloji Dergisi, 2017
Objectives: To investigate the relationship between serum carbonic anhydrase I-II (CA-I and II) autoantibody levels and diabetic retinopathy (DRP) in cases with type 1 diabetes. Materials and Methods: A total of 37 type-1 diabetic patients, 17 with DRP (
Adem Türk, Süleyman Mollamehmetoğlu, Ahmet Alver, Ahmet Menteşe, İrfan Nuhoğlu, Cihangir Erem, Halil İbrahim İmamoğlu   +6 more
doaj   +1 more source

SERPINB3 delays glomerulonephritis and attenuates the lupus-like disease in lupus murine models by inducing a more tolerogenic immune phenotype [PDF]

, 2018
Objective: To explore the effects of SERPINB3 administration in murine lupus models with a focus on lupus-like nephritis. Methods: 40 NZB/W F1 mice were subdivided into 4 groups and intraperitoneally injected with recombinant SERPINB3 (7.5 \u3bcg/0.1 mL ...
Beggio, M, Biasiolo, A, Cappon, A, Cavicchioli, L, Codolo, G, Doria, A., Gatto, M, Ghirardello, A, Luisetto, R, Maggioni, G, Pontisso, P, Saccon, F, Venturini, R   +12 more
core   +2 more sources

GPCR-specific autoantibody signatures are associated with physiological and pathological immune homeostasis

Nature Communications, 2018
Autoantibodies have been associated with autoimmune diseases. However, studies have identified autoantibodies in healthy donors (HD) who do not develop autoimmune disorders.
O. Cabral-Marques, A. Marques, L. Giil, R. De Vito, J. Rademacher, J. Günther, T. Lange, J. Humrich, S. Klapa, S. Schinke, L. Schimke, Gabriele Marschner, S. Pitann, S. Adler, R. Dechend, D. Müller, I. Braicu, J. Sehouli, K. Schulze-Forster, T. Trippel, C. Scheibenbogen, A. Staff, P. Mertens, Madlen Löbel, Justin Mastroianni, C. Plattfaut, F. Gieseler, D. Dragun, B. Engelhardt, M. Fernandez-Cabezudo, H. Ochs, B. al-Ramadi, P. Lamprecht, A. Mueller, H. Heidecke, G. Riemekasten   +35 more
semanticscholar   +1 more source

The Autoantibody Array Assay: A Novel Autoantibody Detection Method

Diagnostics, 2023
Systemic sclerosis (SSc) and dermatomyositis (DM) are autoimmune collagen diseases. Specific autoantibodies are known to be involved in their pathogeneses, each presenting with a different clinical manifestation.
Yuta Norimatsu, Kazuki Mitsuru Matsuda, Kei Yamaguchi, Chihiro Ono, Taishi Okumura, Emi Kogo, Hirohito Kotani, Teruyoshi Hisamoto, Ai Kuzumi, Takemichi Fukasawa, Asako Yoshizaki-Ogawa, Naoki Goshima, Shinichi Sato, Ayumi Yoshizaki   +13 more
doaj   +1 more source

Stratification of Systemic Lupus Erythematosus Patients Using Gene Expression Data to Reveal Expression of Distinct Immune Pathways [PDF]

, 2020
Systemic lupus erythematosus (SLE) is the tenth leading cause of death in females 15-24 years old in the US. The diversity of symptoms and immune pathways expressed in SLE patients causes difficulties in treating SLE as well as in new clinical trials.
arxiv   +1 more source

Prevalence and Outcome of Serum Autoantibodies in Chronic Hepatitis C Patients Undergoing Direct-Acting Antiviral Treatment

Frontiers in Immunology, 2022
BackgroundChronic immune stimulation by hepatitis C virus (HCV) may cause occurrence of several autoantibodies in infected patients, with or without features of clinically overt autoimmune diseases.
Ciro Romano, Olga Tortorella, Liliana Dalla Mora, Dario Di Stasio, Ausilia Sellitto, Luigi Elio Adinolfi, Aldo Marrone   +6 more
doaj   +1 more source

Autoantibody Reversion: Changing Risk Categories in Multiple-Autoantibody–Positive Individuals

Diabetes Care, 2020
OBJECTIVE Most individuals with two or more islet autoantibodies progress to clinical type 1 diabetes. However, in some individuals, autoantibodies are subsequently lost.
Michelle So, Colin O'rourke, H. Bahnson, C. Greenbaum, C. Speake   +4 more
semanticscholar   +1 more source