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Molecular Portrait of Autoantigens in Type 1 Diabetes [PDF]

Biomolecules
This review focuses on the molecular pathogenesis of Type 1 diabetes (T1D), specifically on the key autoantigens targeted by the autoimmune response and the clinical implications of their epitope specificity.
Ilya Kandinov, Anastasia Knyazeva, Elizaveta Lander, Dmitry Gryadunov, Elena Savvateeva   +4 more
doaj   +2 more sources

Preclinical Models to Evaluate the Human Response to Autoantigen and Antigen-Specific Immunotherapy in Human Type 1 Diabetes

Frontiers in Endocrinology, 2022
Type 1 Diabetes (T1D) is an autoimmune disease that results from the destruction of pancreatic islet β-cells by auto-reactive T cells. The clinical management of T1D faces the lack of fully predictive biomarkers in its preclinical stage and of antigen ...
Pamela Houeiss, Pamela Houeiss, Christian Boitard, Christian Boitard, Sandrine Luce, Sandrine Luce   +5 more
doaj   +1 more source

Fcγ receptor activation mediates vascular inflammation and abdominal aortic aneurysm development

Clinical and Translational Medicine, 2021
Background Abdominal aortic aneurysm (AAA), a degenerative vascular pathology characterized by permanent dilation of the aorta, is considered a chronic inflammatory disease involving innate/adaptive immunity.
Laura Lopez‐Sanz, Susana Bernal, Luna Jimenez‐Castilla, Ignacio Prieto, Sara La Manna, Sergio Gomez‐Lopez, Luis Miguel Blanco‐Colio, Jesus Egido, Jose Luis Martin‐Ventura, Carmen Gomez‐Guerrero   +9 more
doaj   +1 more source

Aminoacyl-tRNA Synthetases: On Anti-Synthetase Syndrome and Beyond

Frontiers in Immunology, 2022
Anti-synthetase syndrome (ASSD) is an autoimmune disease characterized by the presence of autoantibodies targeting one of several aminoacyl t-RNA synthetases (aaRSs) along with clinical features including interstitial lung disease, myositis, Raynaud’s ...
Angeles S. Galindo-Feria, Angeles S. Galindo-Feria, Antonella Notarnicola, Ingrid E. Lundberg, Ingrid E. Lundberg, Begum Horuluoglu, Begum Horuluoglu   +6 more
doaj   +1 more source

An Autoantigen Atlas From Human Lung HFL1 Cells Offers Clues to Neurological and Diverse Autoimmune Manifestations of COVID-19

Frontiers in Immunology, 2022
COVID-19 is accompanied by a myriad of both transient and long-lasting autoimmune responses. Dermatan sulfate (DS), a glycosaminoglycan crucial for wound healing, has unique affinity for autoantigens (autoAgs) from apoptotic cells.
Julia Y. Wang, Wei Zhang, Victor B. Roehrl, Michael W. Roehrl, Michael H. Roehrl, Michael H. Roehrl   +5 more
doaj   +1 more source

B‐cell receptors of EBV‐negative Burkitt lymphoma bind modified isoforms of autoantigens

eJHaem, 2022
Burkitt lymphoma (BL) represents the most aggressive B‐cell‐lymphoma. Beside the hallmark of IG‐MYC‐translocation, surface B‐cell receptor (BCR) is expressed, and mutations in the BCR pathway are frequent.
Theresa Bock, Moritz Bewarder, Onur Cetin, Natalie Fadle, Evi Regitz, Eva C. Schwarz, Jana Held, Sophie Roth, Stefan Lohse, Thorsten Pfuhl, Rabea Wagener, Sigrun Smola, Sören L. Becker, Rainer Maria Bohle, Lorenz Trümper, Reiner Siebert, Martin‐Leo Hansmann, Michael Pfreundschuh, Hans G. Drexler, Markus Hoth, Boris Kubuschok, Klaus Roemer, Klaus‐Dieter Preuss, Sylvia Hartmann, Lorenz Thurner   +24 more
doaj   +1 more source

Identification of autoantigens and their potential post-translational modification in EGPA and severe eosinophilic asthma

Frontiers in Immunology, 2023
BackgroundThe chronic airway inflammation in severe eosinophilic asthma (SEA) suggests potential autoimmune aetiology with unidentified autoantibodies analogous to myeloperoxidase (MPO) in ANCA-positive EGPA (eosinophilic granulomatosis with polyangiitis)
Ilaria Esposito, Ioanna Kontra, Chiara Giacomassi, Chiara Giacomassi, Sotiria Manou-Stathopoulou, James Brown, Richard Stratton, Richard Stratton, Galateia Verykokou, Roberto Buccafusca, Michael Stevens, Michael Stevens, Ahuva Nissim, Myles J. Lewis, Paul E. Pfeffer, Paul E. Pfeffer   +15 more
doaj   +1 more source

Oral Dysbiosis and Autoimmunity: From Local Periodontal Responses to an Imbalanced Systemic Immunity. A Review

Frontiers in Immunology, 2020
The current paradigm of onset and progression of periodontitis includes oral dysbiosis directed by inflammophilic bacteria, leading to altered resolution of inflammation and lack of regulation of the inflammatory responses.
Lina J. Suárez, Hernan Garzón, Silie Arboleda, Adriana Rodríguez   +3 more
doaj   +1 more source

Setting the Stage for Insulin Granule Dysfunction during Type-1-Diabetes: Is ER Stress the Culprit?

Biomedicines, 2022
Type-1-diabetes (T1D) is a multifactorial disorder with a global incidence of about 8.4 million individuals in 2021. It is primarily classified as an autoimmune disorder, where the pancreatic β-cells are unable to secrete sufficient insulin.
Aishwarya A. Makam, Anusmita Biswas, Lakshmi Kothegala, Nikhil R. Gandasi   +3 more
doaj   +1 more source

Antigen-Presenting Cells in Psoriasis

Life, 2022
Psoriasis is classically considered a chronic inflammatory skin disorder, however the identification of autoantigens in its pathogenesis established it as a T cell mediated autoimmune disease.
Dóra Antal, Shahrzad Alimohammadi, Péter Bai, Attila Gábor Szöllősi, Magdolna Szántó   +4 more
doaj   +1 more source