Results 1 to 10 of about 64,232 (366)

Triggers of Autoimmunity: The Role of Bacterial Infections in the Extracellular Exposure of Lupus Nuclear Autoantigens

Frontiers in Immunology, 2019
Infections are considered important environmental triggers of autoimmunity and can contribute to autoimmune disease onset and severity. Nucleic acids and the complexes that they form with proteins—including chromatin and ribonucleoproteins—are the main ...
Connie C Qiu, Roberto Caricchio, Stefania Gallucci   +2 more
exaly   +4 more sources

A Spectrum of Neural Autoantigens, Newly Identified by Histo-Immunoprecipitation, Mass Spectrometry, and Recombinant Cell-Based Indirect Immunofluorescence

Frontiers in Immunology, 2018
BackgroundA plurality of neurological syndromes is associated with autoantibodies against neural antigens relevant for diagnosis and therapy. Identification of these antigens is crucial to understand the pathogenesis and to develop specific immunoassays.
Lars Komorowski
exaly   +4 more sources

The exposure of autoantigens by microparticles underlies the formation of potent inflammatory components: the microparticle‐associated immune complexes [PDF]

EMBO Molecular Medicine, 2012
Immunoglobulins, antigens and complement can assemble to form immune complexes (IC). ICs can be detrimental as they propagate inflammation in autoimmune diseases.
Nathalie Cloutier, Sisareuth Tan, Luc H. Boudreau, Catriona Cramb, Roopashree Subbaiah, Lauren Lahey, Alexandra Albert, Ruslan Shnayder, Reuben Gobezie, Peter A. Nigrovic, Richard W. Farndale, William H. Robinson, Alain Brisson, David M. Lee, Eric Boilard   +14 more
doaj   +3 more sources

Autoimmune Diseases and Molecular Mimicry in Tuberculosis [PDF]

Biology
Comorbidities in tuberculosis patients are increasing annually. Autoimmune pathology may influence the diagnosis and treatment of tuberculosis (TB). However, the molecular mimicry between Mycobacterium tuberculosis (Mtb) and human autoantigens is an ...
Leonid P. Churilov, Muslimbek G. Normatov, Hong Ling, Min Zhuang, Dmitry Kudlay, Anna Starshinova   +5 more
doaj   +2 more sources

Characterization and epitope mapping of human monoclonal antibodies to PDC-E2, the immunodominant autoantigen of primary biliary cirrhosis [PDF]

, 1992
Further to define the epitopes of PDC-E2, the major autoantigen in primary biliary cirrhosis (PBC), we have developed and characterized five human monoclonal antibodies. These antibodies were derived by fusing a regional hepatic lymph node from a patient
Bassendine, Baum, Casali, Chambers, Coppel, Coppel, Cram, Flannery, Fregeau, Fregeau, Fujikura, Fusey, Fussey, Gershwin, Gershwin, Griffin, Griffin, James, Kaplan, Kunicki, Larrick, Leung, Leung, Mackay, Mackay, Mathews, McNeilage, Okamoto, Pollack, Ramsden, Reeves, Reimer, Robbins, Rokeach, Rowley, Ruther, Salemuddin, Sturgess, Sudin, Surh, Surh, Surh, Surh, Tan, Uibo, Van de Water, Van de Water, Van de Water, Van de Water, Williams   +49 more
core   +3 more sources

Aminoacyl-tRNA Synthetases: On Anti-Synthetase Syndrome and Beyond

Frontiers in Immunology, 2022
Anti-synthetase syndrome (ASSD) is an autoimmune disease characterized by the presence of autoantibodies targeting one of several aminoacyl t-RNA synthetases (aaRSs) along with clinical features including interstitial lung disease, myositis, Raynaud’s ...
Angeles S. Galindo-Feria, Angeles S. Galindo-Feria, Antonella Notarnicola, Ingrid E. Lundberg, Ingrid E. Lundberg, Begum Horuluoglu, Begum Horuluoglu   +6 more
doaj   +1 more source

An Autoantigen Atlas From Human Lung HFL1 Cells Offers Clues to Neurological and Diverse Autoimmune Manifestations of COVID-19

Frontiers in Immunology, 2022
COVID-19 is accompanied by a myriad of both transient and long-lasting autoimmune responses. Dermatan sulfate (DS), a glycosaminoglycan crucial for wound healing, has unique affinity for autoantigens (autoAgs) from apoptotic cells.
Julia Y. Wang, Wei Zhang, Victor B. Roehrl, Michael W. Roehrl, Michael H. Roehrl, Michael H. Roehrl   +5 more
doaj   +1 more source

Retinal glycoprotein enrichment by concanavalin a enabled identification of novel membrane autoantigen synaptotagmin-1 in equine recurrent uveitis. [PDF]

, 2012
Complete knowledge of autoantigen spectra is crucial for understanding pathomechanisms of autoimmune diseases like equine recurrent uveitis (ERU), a spontaneous model for human autoimmune uveitis. While several ERU autoantigens were identified previously,
A Lux, AK Berntson, AK Steck, B Wiggert, Barbara Amann, BD McNeil, BM Spiess, C Eberhardt, C Kiel, CA Deeg, CA Deeg, CA Deeg, CA Deeg, CA Deeg, CA Deeg, CA Deeg, CA Deeg, CM Kalsow, Cornelia A. Deeg, CW Morgans, D Josic, D Schubert, ER Chapman, G Glavan, H de Wit, Hassan Y. Naim, HY Naim, J Petersen, J Ratelade, JK Zipplies, JP Collin, JW Becker, K Marino, KF Greif, KS Shamsi, LN Troelsen, Lucienne Chatenoud, M Mirshahi, M Takamori, M Takamori, M Takamori, M Takamori, M Vrljic, M Zhao, MA Koontz, Margarete E. Swadzba, MC Ehrenhofer, MC Kwok, MC Papadopoulos, ME Swadzba, MJ Lewis, N Martin-Moutot, P Ariel, P David, P Redecker, RA Levy, RL Degroote, RR Caspi, S Bohm, SM Hauck, SM Hauck, Stefanie M. Hauck, V Gauba, VA Lennon, VA Lennon, W Han, W Vennekate, XQ Liu, Y Wang   +68 more
core   +8 more sources

Fcγ receptor activation mediates vascular inflammation and abdominal aortic aneurysm development

Clinical and Translational Medicine, 2021
Background Abdominal aortic aneurysm (AAA), a degenerative vascular pathology characterized by permanent dilation of the aorta, is considered a chronic inflammatory disease involving innate/adaptive immunity.
Laura Lopez‐Sanz, Susana Bernal, Luna Jimenez‐Castilla, Ignacio Prieto, Sara La Manna, Sergio Gomez‐Lopez, Luis Miguel Blanco‐Colio, Jesus Egido, Jose Luis Martin‐Ventura, Carmen Gomez‐Guerrero   +9 more
doaj   +1 more source

Preclinical Models to Evaluate the Human Response to Autoantigen and Antigen-Specific Immunotherapy in Human Type 1 Diabetes

Frontiers in Endocrinology, 2022
Type 1 Diabetes (T1D) is an autoimmune disease that results from the destruction of pancreatic islet β-cells by auto-reactive T cells. The clinical management of T1D faces the lack of fully predictive biomarkers in its preclinical stage and of antigen ...
Pamela Houeiss, Pamela Houeiss, Christian Boitard, Christian Boitard, Sandrine Luce, Sandrine Luce   +5 more
doaj   +1 more source