Results 101 to 110 of about 64,232 (366)

Autoantibodies, Oxidative Stress, and Nutritional State in Anorexia Nervosa

open access: yesAntibodies
Background/Objectives: Anorexia nervosa (AN) is a complex psychiatric disorder characterized by an extreme fear of gaining weight, leading to severe calorie restriction and weight loss.
Andrea Amerio   +7 more
doaj   +1 more source

Interleukin-10+ Regulatory B Cells Arise Within Antigen-Experienced CD40+ B Cells to Maintain Tolerance to Islet Autoantigens

open access: yesDiabetes, 2014
Impaired regulatory B cell (Breg) responses are associated with several autoimmune diseases in humans; however, the role of Bregs in type 1 diabetes (T1D) remains unclear.
S. Kleffel   +15 more
semanticscholar   +1 more source

Autoantibody response towards chromatin in patients with juvenile idiopathic arthritis

open access: yesArthritis &Rheumatology, Accepted Article.
Objective Juvenile idiopathic arthritis (JIA) patients frequently exhibit antinuclear antibodies (ANAs), but the specific antigen target recognized by them and the presence of additional autoantibody specificities in JIA patients remains elusive. Methods Plasma samples from 110 untreated patients with active JIA, as well as from 14 children with ...
Viola Pitkänen   +13 more
wiley   +1 more source

The nature of the post-translational modifications of the autoantigen LL37 influences the autoreactive T-helper cell phenotype in psoriasis

open access: yesFrontiers in Immunology
Psoriasis is a chronic skin disease evolving to psoriatic arthritis (PsA) in 30% of cases. LL37 is a psoriasis T-cell autoantigen and, in complex with self-DNA/RNA, a trigger of type I interferon (IFN-I) and pro-inflammatory factors in dendritic cells ...
Roberto Lande   +15 more
doaj   +1 more source

Peripheral blood biomarkers in multiple sclerosis. [PDF]

open access: yes, 2015
Multiple sclerosis is the most common autoimmune disorder affecting the central nervous system. The heteroge-neity of pathophysiological processes in MS contributes to the highly variable course of the disease and unpre-dictable response to therapies ...
Acheson   +298 more
core   +1 more source

B cells and systemic sclerosis interstitial lung disease

open access: yesArthritis &Rheumatology, Accepted Article.
Interstitial lung disease is an important complication of systemic sclerosis (SSc‐ILD) with high mortality and morbidity. Recent clinical studies in SSc‐ILD have led to FDA‐approved therapies in SSc‐ILD. Importantly, evidence from these studies has been extrapolated to guide management of interstitial lung diseases of other systemic autoimmune ...
Nina Goldman   +2 more
wiley   +1 more source

Post-translational modifications, subcellular relocation and release in apoptotic microparticles: apoptosis turns nuclear proteins into autoantigens.

open access: yesFolia Histochemica et Cytobiologica, 2010
Autoantibodies against particular nuclear components, such as chromatin and snRNPs, are a characteristic feature of the autoimmune disease systemic lupus erythematosus.
Sylviane Muller, JĂźrgen Dieker
doaj   +1 more source

An Epigenetics-Based Hypothesis of Autoantigen Development in Systemic Lupus Erythematosus

open access: yesEpigenomes, 2020
Currently, we have a limited understanding of mechanisms leading to systemic lupus erythematosus, but we know that genetics, environmental factors, and epigenetics contribute to the disease. One common aspect of the various environmental triggers is that
Wesley Brooks
doaj   +1 more source

RNA-associated autoantigens activate B cells by combined B cell antigen receptor/Toll-like receptor 7 engagement

open access: yesJournal of Experimental Medicine, 2005
Previous studies (Leadbetter, E.A., I.R. Rifkin, A.H. Hohlbaum, B. Beaudette, M.J. Shlomchik, and A. Marshak-Rothstein. 2002. Nature. 416:603–607; Viglianti, G.A., C.M. Lau, T.M. Hanley, B.A. Miko, M.J. Shlomchik, and A. Marshak-Rothstein. 2003. Immunity.
Christina M. Lau   +10 more
semanticscholar   +1 more source

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