Results 141 to 150 of about 33,778 (258)

DAMPs, PAMPs, and Alarmins: From Mechanism to Therapy

MedComm, Volume 7, Issue 9, September 2026.
This review synthesizes the expanding biology of PAMPs and DAMPs, from their molecular sources and sensing mechanisms to regulatory networks that govern inflammation and homeostasis. Spanning from classical immune activation to trained immunity and interorgan communication, we highlight the interplay between PAMPs and DAMPs and their context‐dependent ...
Xuanxuan Yu, Yuqin Jin, Baochao Li, Jie Deng, Yiwen Zhou, Jinglun Zhang, Huang Li   +6 more
wiley   +1 more source

Role of Tertiary Lymphoid Structures in Autoimmune Diseases and Cancer

MedComm, Volume 7, Issue 9, September 2026.
Schematic overview of tertiary lymphoid structures (TLSs): The development process, detection, and the immune function that depends on the environment in different disease contexts of TLS. TLSs originate from loose lymphoid aggregates that acquire ordered follicular architecture to become primary follicular‐like TLS, before maturing into ...
Ze Yan, Bin Wen, Ying Hu, Xiaocui Wang, Xuemei Duan, Haonan Li, Shumin Dong, Yufeng Fan, Caihong Wang, Shutong Yang, Huifeng Shang, Yukai Jing   +11 more
wiley   +1 more source

EBNA1_381-452 and Cross-Reactive Antibody Responses Reveal Immune Signatures in Multiple Sclerosis. [PDF]

Neurol Neuroimmunol Neuroinflamm
De Wit D, Beliën J, David M, Swinnen S, Dedoncker N, Yshii L, Dubois B.   +6 more
europepmc   +1 more source

Tissue‐Resident Macrophage in Inflammation and Cancer

MedComm, Volume 7, Issue 9, September 2026.
Opposing macrophage functions in inflammation and cancer converge on shared mechanistic nodes, informing cross‐disease therapeutic strategies. ABSTRACT Tissue‐resident macrophages (TRMs) are long‐lived immune cells strategically distributed across organs, where their functional plasticity enables both homeostatic maintenance and pathological ...
Siyuan Huang, Jiangbo Fan, Wenyi Liu, Di Liu, Rui Wang, Yuanyang Wang, Jianhui Sun, Huacai Zhang, Qingli Cai, Zhe Xu, Fang Xu, Jianxin Jiang, Zhen Wang, Ling Zeng   +13 more
wiley   +1 more source

Large-Scale Autoantibody Reactome Analysis Reveals Shared and Specific Signatures Across Different Immune-Mediated Inflammatory Diseases. [PDF]

ACR Open Rheumatol
Bai Z, Yu B, Wei Z, Xiao P, Zhan M, Li M, Wang F, Cheng Y, Zhao M, Zhang C, Zhang X, Yu X, Liu Y.   +12 more
europepmc   +1 more source

Current Cell/Organoid and Animal Models for Primary Sclerosing Cholangitis

Portal Hypertension &Cirrhosis, Volume 5, Issue 3, Page 241-259, September 2026.
Primary sclerosing cholangitis (PSC) is a chronic cholestatic liver disease with limited therapeutic options and a marked risk of progression to biliary fibrosis, cirrhosis, and malignancy. Progress in PSC research has been hindered by the lack of models that faithfully recapitulate the complex biliary microenvironment and disease heterogeneity ...
Qigu Yao, Sheng Cheng, Qiaoling Pan, Jiong Yu, Hongcui Cao   +4 more
wiley   +1 more source

Preliminary Evidence for Autoimmune Regulator Occupancy at Promoter Regions of Known Autoantigens in Human Peripheral Lymphocytes Obtained by Chromatin Immunoprecipitation Assay. [PDF]

Int J Mol Sci
Nardella C, Mezzani I, Pace E, Fierabracci A.   +3 more
europepmc   +1 more source

Differential Expression of Human and Bacterial Proteins Reveals Microbiome–Host Crosstalk in Metabolic Disorders

PROTEOMICS – Clinical Applications, Volume 20, Issue 5, September 2026.
ABSTRACT Purpose The growing prevalence of obesity, MetS, and T2DM highlights the need to better understand host–microbiota interactions. While gut microbiota has been widely investigated, interactions between the oral microbiota and human salivary proteins remain largely unexplored.
Carlos Vinicius Ferreira da Silva, Carlos José Ferreira da Silva, Fernanda da Silva Marinho, Youssef Bacila Sade, Sandra Mara Naressi Scapin, Fabiano L. Thompson, Cristiane Thompson, Eidy de Oliveira Santos   +7 more
wiley   +1 more source

Effects of maternal autoantibody exposure at the cellular level: implications for the developing brain. [PDF]

Front Psychiatry
Blumenthal KH, McLellan J, Van de Water J.   +2 more
europepmc   +1 more source

Cancer survivorship in malignant melanoma

JDDG: Journal der Deutschen Dermatologischen Gesellschaft, Volume 24, Issue 9, Page e1291-e1308, September 2026.
Summary Robust long‐term survival data have transformed the prognosis of metastatic melanoma. For combination therapy with immune checkpoint inhibitors (ICIs), 10‐year melanoma‐specific survival rates now exceed 50 %, and durable disease control is achievable in a substantial proportion of patients, including those with brain metastases.
Markus Reitmajer, Susanne Dugas‐Breit, Chiara L. Blomen, Elisabeth Livingstone, Max Schlaak, Markus V. Heppt, Michael M. Sachse, Madlen Hörold, Friedegund Meier, Sebastian Haferkamp, Christian Apfelbacher, Georgia Schilling, Andrea von den Berg, Frank Meiss, Lisa Zimmer, Andrea Forschner   +15 more
wiley   +1 more source