Results 131 to 140 of about 44,843 (259)

Cross-reactive immune responses between enteroviruses and islet cell autoantigens [PDF]

open access: yes, 2002
Ohjaaja Merja Roivainen/MIBO ...
Härkönen, Taina
core  

Single‐Cell RNA Sequencing Informs Precision Targeting of Monogenic Lupus Associated With IKZF1 Haploinsufficiency

open access: yesArthritis &Rheumatology, Volume 78, Issue 6, Page 1231-1244, June 2026.
Objective This study aimed to investigate the mechanisms of immune dysregulation in a pediatric patient with monogenic lupus driven by IKZF1 haploinsufficiency. Methods Peripheral immune cells from a patient with IKZF1 haploinsufficiency, patients with lupus with no currently known genetic mutations, and healthy controls were analyzed using single‐cell
Qi Zheng   +6 more
wiley   +1 more source

Bone Marrow Failure Model Mimics Aplastic Anemia Patients: Single‐Cell Landscape of Immune Response Reveals Novel Mechanisms of Immune Imbalance in AA

open access: yesCancer Medicine, Volume 15, Issue 6, June 2026.
Single‐cell RNA‐seq is used in a mouse model of immune‐mediated bone marrow failure. Approach to platelets and mitochondrial data. Analysis of various immune cell landscapes, interactions and driving factors in BMF, involving platelets, CD4+ T Cells, CD8+ T Cells, macrophages, and mitochondrial energy metabolism pathways.
Shuai Tan   +5 more
wiley   +1 more source

Alterations of circulating innate lymphoid cells in recent‐onset type 1 diabetes

open access: yesClinical &Translational Immunology, Volume 15, Issue 6, 2026.
Circulating innate lymphoid cells (ILC) in patients with recent‐onset type 1 diabetes (T1D) show a chronic activation and a primed phenotype, with overexpression of HLA Class II (ILC1 and ILCP) and dysregulation of costimulatory and migratory mRNA transcripts. Glucose and cytokines (IL‐1β) mediate circulating ILC activation and HLA Class II expression.
Ariadna Roig   +5 more
wiley   +1 more source

The Role of Neutrophils and NETosis in Diseases: The Implications for Therapy

open access: yesMedComm, Volume 7, Issue 6, June 2026.
Neutrophils secrete cytokines, express specific surface proteins, increase or decrease in cell count, and their ratio to lymphocyte count can be used as biomarkers to characterize collective status and disease progression. Neutrophils can monitor and track the body's health status, “Wei Bing” status, disease status, and different times of disease ...
Zhen Ma   +6 more
wiley   +1 more source

Ribosomal Proteins in Cell Biology and Cancer

open access: yesMedComm – Oncology, Volume 5, Issue 2, June 2026.
The functions of ribosomal proteins (RPs) extend beyond the conventional translation process, as they also regulate gene expression, stress responses, and disease progression. Dysregulation of RPs contributes to the onset and progression of various diseases, including cancer and ribosomopathies, underscoring their dual role as critical disease ...
Ao Zhang   +4 more
wiley   +1 more source

Key autoantigens in SLE [PDF]

open access: yesRheumatology, 2005
G, Riemekasten, B H, Hahn
openaire   +2 more sources

Evaluation of Photophysical Properties and Biological Applications of Diarylmethanes

open access: yesChemistryOpen, Volume 15, Issue 6, June 2026.
The wide applications of diarylmethanes were investigated through various experimental and computational approaches. The solvent environment influences the electronic properties of diarylmethanes and hence their drug‐like properties. Interactions with PARP1 revealed stable binding supporting anticancer potential.
H. Ranjini Jenifer   +2 more
wiley   +1 more source

The Role of Inflammation in Infant Colic—A Systematic Review and Meta‐Analysis

open access: yesActa Paediatrica, Volume 115, Issue 6, Page 1158-1169, June 2026.
ABSTRACT Aim Despite being a self‐limiting condition, infant colic is associated with negative consequences for caregivers and infants. Gut inflammation is hypothesised as a contributing factor. We collected and meta‐analysed the most recent evidence on the association between infant colic and gut inflammation.
Dan Boëtius Andersen   +8 more
wiley   +1 more source

CYP2E1 and CYP2D6 in Anti‐Tuberculosis Drug‐Induced Liver Injury: Mechanisms, Epigenetic Regulation, and Translational Implications

open access: yesClinical and Translational Science, Volume 19, Issue 6, June 2026.
ABSTRACT Tuberculosis (TB) continues to be a significant global health issue, with anti‐tuberculosis drug‐induced liver injury (ATDILI) representing the most frequent and severe adverse event associated with first‐line therapy. Despite extensive investigation, the mechanistic basis of ATDILI remains incompletely understood.
Pathida Prakongsup   +1 more
wiley   +1 more source

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