Results 11 to 20 of about 59,330 (297)

The exposure of autoantigens by microparticles underlies the formation of potent inflammatory components: the microparticle-associated immune complexes [PDF]

EMBO Molecular Medicine, 2012
Immunoglobulins, antigens and complement can assemble to form immune complexes (IC). ICs can be detrimental as they propagate inflammation in autoimmune diseases.
Alain Brisson, Alexandra Albert, Bodary SC, Boyum A, Catriona Cramb, Chargaff E, David M. Lee, Eric Boilard, Kurki P, Lauren Lahey, Luc H. Boudreau, Nathalie Cloutier, Nigrovic PA, Peter A. Nigrovic, Reuben Gobezie, Richard W. Farndale, Roopashree Subbaiah, Ruslan Shnayder, Sisareuth Tan, Thiagarajan P, William H. Robinson   +20 more
core   +3 more sources

Identification of novel, clinically correlated autoantigens in the monogenic autoimmune syndrome APS1 by proteome-wide PhIP-Seq

eLife, 2020
The identification of autoantigens remains a critical challenge for understanding and treating autoimmune diseases. Autoimmune polyendocrine syndrome type 1 (APS1), a rare monogenic form of autoimmunity, presents as widespread autoimmunity with T and B ...
Sara E Vazquez, Elise MN Ferré, David W Scheel, Sara Sunshine, Brenda Miao, Caleigh Mandel-Brehm, Zoe Quandt, Alice Y Chan, Mickie Cheng, Michael German, Michail Lionakis, Joseph L DeRisi, Mark S Anderson   +12 more
doaj   +2 more sources

Immunoproteomics technologies in the discovery of autoantigens in autoimmune diseases

Biomolecular Concepts, 2016
Proteomics technologies are often used for the identification of protein targets of the immune system. Here, we discuss the immunoproteomics technologies used for the discovery of autoantigens in autoimmune diseases where immune system dysregulation ...
Ganesan Vinitha, Ascherman Dana P., Minden Jonathan S.   +2 more
doaj   +2 more sources

Autoimmune Diseases and Molecular Mimicry in Tuberculosis. [PDF]

Biology (Basel)
Comorbidities in tuberculosis patients are increasing annually. Autoimmune pathology may influence the diagnosis and treatment of tuberculosis (TB). However, the molecular mimicry between Mycobacterium tuberculosis (Mtb) and human autoantigens is an ...
Churilov LP, Normatov MG, Ling H, Zhuang M, Kudlay D, Starshinova A.   +5 more
europepmc   +2 more sources

Aminoacyl-tRNA Synthetases: On Anti-Synthetase Syndrome and Beyond

Frontiers in Immunology, 2022
Anti-synthetase syndrome (ASSD) is an autoimmune disease characterized by the presence of autoantibodies targeting one of several aminoacyl t-RNA synthetases (aaRSs) along with clinical features including interstitial lung disease, myositis, Raynaud’s ...
Angeles S. Galindo-Feria, Angeles S. Galindo-Feria, Antonella Notarnicola, Ingrid E. Lundberg, Ingrid E. Lundberg, Begum Horuluoglu, Begum Horuluoglu   +6 more
doaj   +1 more source

The DNA sensors AIM2 and IFI16 are SLE autoantigens that bind neutrophil extracellular traps

eLife, 2022
Background: Nucleic acid binding proteins are frequently targeted as autoantigens in systemic lupus erythematosus (SLE) and other interferon (IFN)-linked rheumatic diseases.
B. Antiochos, Daniela Trejo-Zambrano, P. Fenaroli, A. Rosenberg, Alan Baer, Archit Garg, J. Sohn, Jessica Li, M. Petri, D. Goldman, C. Mecoli, L. Casciola-Rosen, A. Rosen   +12 more
semanticscholar   +1 more source

Identification of four novel T cell autoantigens and personal autoreactive profiles in multiple sclerosis

Science Advances, 2022
Multiple sclerosis (MS) is an inflammatory disease of the central nervous system (CNS), in which pathological T cells, likely autoimmune, play a key role. Despite its central importance, the autoantigen repertoire remains largely uncharacterized. Using a
Mattias Bronge, Klara Asplund Högelin, Olivia G Thomas, Sabrina Ruhrmann, C. Carvalho-Queiroz, Ola B. Nilsson, Andreas Kaiser, M. Zeitelhofer, Erik Holmgren, M. Linnerbauer, Milena Z. Adzemovic, C. Hellström, I. Jelcic, Hao Liu, P. Nilsson, J. Hillert, L. Brundin, K. Fink, I. Kockum, K. Tengvall, R. Martin, Hanna Tegel, T. Gräslund, F. Al Nimer, A. O. Guerreiro-Cacais, M. Khademi, G. Gafvelin, T. Olsson, H. Grönlund   +28 more
semanticscholar   +1 more source

An Autoantigen Atlas From Human Lung HFL1 Cells Offers Clues to Neurological and Diverse Autoimmune Manifestations of COVID-19

Frontiers in Immunology, 2022
COVID-19 is accompanied by a myriad of both transient and long-lasting autoimmune responses. Dermatan sulfate (DS), a glycosaminoglycan crucial for wound healing, has unique affinity for autoantigens (autoAgs) from apoptotic cells.
Julia Y. Wang, Wei Zhang, Victor B. Roehrl, Michael W. Roehrl, Michael H. Roehrl, Michael H. Roehrl   +5 more
doaj   +1 more source

Enhanced Expression of Autoantigens During SARS-CoV-2 Viral Infection

Frontiers in Immunology, 2021
Immune homeostasis is disturbed during severe viral infections, which can lead to loss of tolerance to self-peptides and result in short- or long-term autoimmunity.
Narjes Saheb Sharif‐Askari, Fatemeh Saheb Sharif‐Askari, S. Ahmed, S. Hannawi, R. Hamoudi, Q. Hamid, R. Halwani   +6 more
semanticscholar   +1 more source

Fcγ receptor activation mediates vascular inflammation and abdominal aortic aneurysm development

Clinical and Translational Medicine, 2021
Background Abdominal aortic aneurysm (AAA), a degenerative vascular pathology characterized by permanent dilation of the aorta, is considered a chronic inflammatory disease involving innate/adaptive immunity.
Laura Lopez‐Sanz, Susana Bernal, Luna Jimenez‐Castilla, Ignacio Prieto, Sara La Manna, Sergio Gomez‐Lopez, Luis Miguel Blanco‐Colio, Jesus Egido, Jose Luis Martin‐Ventura, Carmen Gomez‐Guerrero   +9 more
doaj   +1 more source