Results 11 to 20 of about 64,232 (366)
eLife, 2020 The identification of autoantigens remains a critical challenge for understanding and treating autoimmune diseases. Autoimmune polyendocrine syndrome type 1 (APS1), a rare monogenic form of autoimmunity, presents as widespread autoimmunity with T and B ...
Sara E Vazquez +12 more
doaj +2 more sources
Immunoproteomics technologies in the discovery of autoantigens in autoimmune diseases
Biomolecular Concepts, 2016 Proteomics technologies are often used for the identification of protein targets of the immune system. Here, we discuss the immunoproteomics technologies used for the discovery of autoantigens in autoimmune diseases where immune system dysregulation ...
Ganesan Vinitha +2 more
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The DNA sensors AIM2 and IFI16 are SLE autoantigens that bind neutrophil extracellular traps
eLife, 2022 Background: Nucleic acid binding proteins are frequently targeted as autoantigens in systemic lupus erythematosus (SLE) and other interferon (IFN)-linked rheumatic diseases.
B. Antiochos +12 more
semanticscholar +1 more source
Science Advances, 2022 Multiple sclerosis (MS) is an inflammatory disease of the central nervous system (CNS), in which pathological T cells, likely autoimmune, play a key role. Despite its central importance, the autoantigen repertoire remains largely uncharacterized. Using a
Mattias Bronge +28 more
semanticscholar +1 more source
Enhanced Expression of Autoantigens During SARS-CoV-2 Viral Infection
Frontiers in Immunology, 2021 Immune homeostasis is disturbed during severe viral infections, which can lead to loss of tolerance to self-peptides and result in short- or long-term autoimmunity.
Narjes Saheb Sharif‐Askari +6 more
semanticscholar +1 more source
Immunogenicity of autoantigens [PDF]
BMC Genomics, 2011 Autoantibodies against self-antigens have been associated not only with autoimmune diseases, but also with cancer and are even found in healthy individuals. The mechanism causing the autoantibody response remains elusive for the majority of the immunogenic antigens. To deepen the understanding of autoantibody responses, we ask whether natural-occurring,
Eckart Meese +7 more
openaire +4 more sources
The nature of autoantigens [PDF]
Memórias do Instituto Oswaldo Cruz, 1987 1. Autoimmunity in deisease is driven by autoantigen; 2. Cell surface molecules may stimulate autoreactive T-helpers if call II MHC is expressed; special factors may predispose to the ease of class II induction; 3. Soluble autoantigens may be focussed by primed B-cells and processed for presentation to T-cell; 4.
Roitt, Ivan M., Cooke, Anne
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B‐cell receptors of EBV‐negative Burkitt lymphoma bind modified isoforms of autoantigens
eJHaem, 2022 Burkitt lymphoma (BL) represents the most aggressive B‐cell‐lymphoma. Beside the hallmark of IG‐MYC‐translocation, surface B‐cell receptor (BCR) is expressed, and mutations in the BCR pathway are frequent.
Theresa Bock +24 more
doaj +1 more source
Frontiers in Immunology, 2020 The current paradigm of onset and progression of periodontitis includes oral dysbiosis directed by inflammophilic bacteria, leading to altered resolution of inflammation and lack of regulation of the inflammatory responses.
Lina J. Suárez +3 more
doaj +1 more source
Autoantigenicity of nucleolar complexes [PDF]
Autoimmunity Reviews, 2003 Autoantibodies targeting nucleolar autoantigens (ANoA) are most frequently found in sera from patients with systemic sclerosis (SSc, also designated scleroderma) or with SSc overlap syndromes. During the last decade an extensive number of nucleolar components have been identified and this allowed a more detailed analysis of the identity of nucleolar ...
Welting, T.J.M. +2 more
openaire +3 more sources