Results 31 to 40 of about 49,748 (241)

Neoepitopes in Type 1 Diabetes: Etiological Insights, Biomarkers and Therapeutic Targets

Frontiers in Immunology, 2021
The mechanisms underlying type 1 diabetes (T1D) pathogenesis remain largely unknown. While autoantibodies to pancreatic beta-cell antigens are often the first biological response and thereby a useful biomarker for identifying individuals in early stages ...
Teresa Rodriguez-Calvo, James D. Johnson, Lut Overbergh, Jessica L. Dunne   +3 more
doaj   +1 more source

Infectious diseases and autoimmunity [PDF]

, 2011
Introduction: Autoimmunity occurs when the immune system recognizes and attacks host tissue. In addition to genetic factors, environmental triggers (in particular viruses, bacteria and other infectious pathogens) are thought to play a major role in the ...
Deidda, Silvia, Delitala, Giuseppe, Delogu, Lucia Gemma, Manetti, Roberto   +3 more
core   +1 more source

Arginine mutation alters binding of a human monoclonal antibody to antigens linked to systemic lupus erythematosus and the antiphospholipid syndrome [PDF]

, 2007
Objective: Previous studies have shown the importance of somatic mutations and arginine residues in the complementarity-determining regions (CDRs) of pathogenic anti-double-stranded DNA (anti-dsDNA) antibodies in human and murine lupus, and in studies of
Giles, I., Ioannou, Y., Isenberg, D.A., Lambrianides, A., Latchman, D.S., Manson, J.J., Mason, L., Rahman, A.   +7 more
core   +1 more source

Microarray ELISA for Autoantibody Screening in Connective Tissue Diseases [PDF]

Journal of Clinical and Diagnostic Research, 2012
Objective: This study was performed to demonstrate the use of an ELISA-based microarray technology which is termed as ‘PictArrays’, to identify autoantibody expression patterns in patients with symptoms of autoimmune connective tissue disease ...
Sarita Kumble, Lok Choi, Carlos Lopez-Muedano, Krishnanand D. Kumble   +3 more
doaj  

Identification of Ocular Autoantigens Associated With Juvenile Idiopathic Arthritis-Associated Uveitis

Frontiers in Immunology, 2019
The purpose of the current study was to analyze the binding patterns of serum autoantibodies from juvenile idiopathic arthritis (JIA) and JIA-associated uveitis (JIAU) patients to proteomes from different ocular tissues and to identify potential ocular ...
Martin Busch, Kira Leona Wefelmeyer, Karoline Walscheid, Kai Rothaus, Dirk Bauer, Cornelia A. Deeg, Roxane L. Degroote, Doreen Ackermann, Simone König, Solon Thanos, Maren Kasper, Arnd Heiligenhaus, Arnd Heiligenhaus, Arnd Heiligenhaus   +13 more
doaj   +1 more source

Gad65 is recognized by t-cells, but not by antibodies from nod-mice [PDF]

, 1994
Since the 64kDa-protein glutamic acid decarboxylase (GAD) is one of the major autoantigens in T-cell mediated Type 1 diabetes, its relevance as a T-cell antigen needs to be clarified. After isolation of splenic T-cells from non-obese diabetic (NOD) mice,
Alzari PM, Atkinson MA, Baekkeskov S, Bieg S, Christgau S, Christie MR, Diaz JL, Eisenbarth GS, Hackett CJ, Honeyman MC, J. Seissler, Jennings PA, L. Herberg, Leiter EH, Lie W, Mauch L, Miller LP, Ohneda A, Peters PJ, Roep BO, Roep BO, S. Bieg, Seissler J, Seissler J, Solimena M, Solimena M, Velloso LA, W. A. Scherbaum, W. Northemann   +28 more
core   +1 more source

Emerging immunopharmacological targets in multiple sclerosis. [PDF]

, 2015
Inflammatory demyelination of the central nervous system (CNS) is the hallmark of multiple sclerosis (MS), a chronic debilitating disease that affects more than 2.5 million individuals worldwide. It has been widely accepted, although not proven, that the
Abdolmohamad Rostami, Abrams, Abrams, Achiron, Adelman, Allen, Bachmann, Bai, Bai, Baker, Balcer, Bar-Or, Bar-Or, Bar-Or, Bar-Or, Ben-Nun, Biasi, Bielekova, Bielekova, Bielekova, Bielekova, Bielekova, Bitar, Bluestone, Bogoljub Ciric, Bour-Jordan, Bourdette, Bourquin, Brambilla, Brocke, Burman, Burns, Burrows, Chaudhuri, Chitnis, Coles, Constantinescu, Constantinescu, Correale, Correale, Cox, Cragg, Crowe, Darlington, Darlington, Disanto, Duddy, Emery, Espinoza-Delgado, Faria, Faria, Farjam, Feinstein, Fissolo, Fletcher, Freedman, Garren, Garren, Garren, Garren, Giovannoni, Giovannoni, Girvin, Girvin, Goodin, Gosselin, Goverman, Goverman, Guang-Xian Zhang, Hale, Hartmann, Hauser, Havrdova, Hawker, He, Hedegaard, Higgins, Hill-Cawthorne, Hilliard, Hilliard, Ho, Hoffmann, Hofman, Jankovic, Jennum, Kappos, Kappos, Karussis, Karussis, Kearney, Kerbrat, Le Page, Li, Liblau, Lider, Lider, Lindsey, Lindsey, Lisak, Liu, Lobell, Lobell, Lohse, Lund, Lyons, Marrie, Marta, Martin, Mease, Medaer, Mestecky, Mikulkova, Miller, Milo, Mirshafiey, Mojtaba Farjam, Moreau, Mowat, Nicoletti, Nightingale, O'Brien, Offner, Offner, Oh, Oksenberg, Pender, Pettitt, Phillips, Phillips, Podojil, Poli, Pozzilli, Pryce, Quintana, Racioppi, Rasouli, Robinson, Rose, Rose, Rostami, Sandrini, Schaub, Sclerosis, Selmaj, Selmaj, Sinha, Smith, Spuler, Stuve, Taoufik, Tsunoda, Turley, Turley, Turner, van Boxel-Dezaire, van den Hoogen, Van der Walt, van Oosten, van Oosten, van Oosten, Vandenbark, Vandenbark, Viglietta, Viglietta, Vollmer, Walczak, Waldmann, Wang, Weber, Wefer, Weiner, Weiner, Weissert, Willis, Wucherpfennig, Wynn, Xing, Yadav, Zang, Zhang, Zhang, Zhang, Zhang   +182 more
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Autoantigenicity of nucleolar complexes [PDF]

Autoimmunity Reviews, 2003
Autoantibodies targeting nucleolar autoantigens (ANoA) are most frequently found in sera from patients with systemic sclerosis (SSc, also designated scleroderma) or with SSc overlap syndromes. During the last decade an extensive number of nucleolar components have been identified and this allowed a more detailed analysis of the identity of nucleolar ...
Welting, T.J.M., Raijmakers, R., Pruijn, G.J.M.   +2 more
openaire   +2 more sources

Morbid Sequences Suggest Molecular Mimicry between Microbial Peptides and Self-Antigens: A Possibility of Inciting Autoimmunity

Frontiers in Microbiology, 2017
Understanding etiology of autoimmune diseases has been a great challenge for designing drugs and vaccines. The pathophysiology of many autoimmune diseases may be attributed to molecular mimicry provoked by microbes.
Susanta Pahari, Susanta Pahari, Deepyan Chatterjee, Shikha Negi, Jagdeep Kaur, Balvinder Singh, Javed N. Agrewala   +6 more
doaj   +1 more source

Bullous pemphigoid autoantibodies

AIMS Allergy and Immunology, 2021
Autoimmune blistering skin disorders are rare. According to direct immunofluorescence studies, three categories are described: pemphigus group, pemphigoid group and dermatitis herpetiformis.
Florentina-Silvia Delli, Elena Sotiriou, Efstratios Vakirlis, Demetrios Ioannides   +3 more
doaj   +1 more source