Results 71 to 80 of about 27,579 (221)

Cardiovascular toxicity from immune checkpoint inhibitor therapy: an inflammatory continuum

British Journal of Pharmacology, EarlyView.
Immune checkpoint inhibitor (ICI) therapy has markedly improved outcomes in advanced malignancies but has also revealed a distinct spectrum of cardiovascular immune‐related adverse events. Myocarditis represents the most severe manifestation, while non‐inflammatory left ventricular dysfunction and vascular inflammation have emerged as additional ...
Fabrice Reyes, Florian Buehning, Tobias Lerchner, Julia Vogel, Raluca I. Mincu, Matthias Totzeck, Tienush Rassaf, Lars Michel   +7 more
wiley   +1 more source

Immune system markers of neuroinflammation in patients with clinical diagnose of neuromyelitis optica Marcadores imunológicos em pacientes com diagnóstico de neuromielite óptica

Arquivos de Neuro-Psiquiatria, 2008
Neuromyelitis optica (NMO) is an inflammatory, demyelinating disease of the central nervous system characterized by the association of a serious myelitis and unilateral or bilateral optic neuritis.
Soniza Vieira Alves-Leon, Maria Lucia Vellutini Pimentel, Gabrielle Sant'Anna, Fabíola Rachid Malfetano, Cláudio Duque Estrada, Thereza Quirico- Santos   +5 more
doaj   +1 more source

Cold plasma treatment for oral lichen planus: a retrospective case collection and proposal of a new clinical score

JDDG: Journal der Deutschen Dermatologischen Gesellschaft, EarlyView.
Summary Background and objectives Oral lichen planus (OLP) is a chronic autoimmune mucosal disease with malignant potential and limited treatment options. This study evaluated the long‐term efficacy and safety of cold atmospheric plasma (CAP) therapy in therapy‐refractory OLP and introduced the novel Lichen Planus Severity Score (LPSS).
Christian Seebauer, Hans‐Robert Metelmann, Mohamed Falougy, Wolfram Kaduk, Lasse Kremer, Georg Daeschlein   +5 more
wiley   +1 more source

HLA class I-naturally presented synovial tissue peptides are recognized by CD8+ T lymphocytes from rheumatoid arthritis patients

Frontiers in Immunology
IntroductionRheumatoid arthritis (RA) is an autoimmune disease resulting from a response driven by self-reactive CD4+ T cells that recognize autoantigenic peptides presented by antigen-presenting cells (APCs).
Diego Catalán, Daniela Schneider, Bárbara Pesce, Miqueas Jaime, Lucero Toro, Constanza Varela-Villarroel, Darly Montano-Bruno, Lilian Soto, Lilian Soto, Francisca Bozán, María Carolina Cuéllar-Gutiérrez, María Carolina Cuéllar-Gutiérrez, Óscar Neira, Consuelo Arroyo, Guido Rivera, Milton Larrondo, Jaime Hinzpeter, Montserrat Carrascal, Montserrat Carrascal, Juan C. Aguillón, Jaxaira Maggi   +20 more
doaj   +1 more source

Autoantibodies in Systemic Lupus Erythematosus Target Mitochondrial RNA

Frontiers in Immunology, 2019
The mitochondrion supplies energy to the cell and regulates apoptosis. Unlike other mammalian organelles, mitochondria are formed by binary fission and cannot be directly produced by the cell.
Yann Becker, Geneviève Marcoux, Isabelle Allaeys, Anne-Sophie Julien, Renée-Claude Loignon, Hadrien Benk-Fortin, Emmanuelle Rollet-Labelle, Joyce Rauch, Paul R. Fortin, Paul R. Fortin, Paul R. Fortin, Eric Boilard, Eric Boilard   +12 more
doaj   +1 more source

Anti‐Integrin αvβ6 Autoantibodies as Diagnostic and Monitoring Biomarkers for Pediatric‐Onset Primary Sclerosing Cholangitis

Hepatology Research, EarlyView.
Levels of anti‐integrin αvβ6 antibodies were significantly higher in pediatric‐onset primary sclerosing cholangitis (PSC) than in autoimmune hepatitis (AIH) and may reflect disease activity. These antibodies may serve as a novel biomarker for distinguishing PSC from AIH and for monitoring disease progression.
Yukako Maeda, Shuichiro Umetsu, Eitaro Hiejima, Mitsuyoshi Suzuki, Itaru Iwama, Takeshi Kimura, Sonoko Kondo, Ayano Inui, Hiroki Kondou, Tatsuya Okamoto, Takashi Ito, Hiroyuki Shirahase, Kazushi Izawa, Takahiro Yasumi, Takeshi Kuwada, Masahiro Shiokawa, Hiroshi Seno, Junko Takita   +17 more
wiley   +1 more source

Sclera-Specific and non-sclera-specific autoantibodies in the serum of patients with non-infectious anterior scleritis Auto-anticorpos contra antígenos específicos e não-específicos da esclera no soro de pacientes com esclerite anterior não-infecciosa

Revista Brasileira de Reumatologia, 2007
OBJECTIVES: to study the frequency and specificity of sclera-specific and non-sclera-specific autoantibodies in the sera of patients with anterior non-infectious scleritis. METHODS: prospective study involving 25 patients examined at the sector of Cornea
Wagner Koji Aragaki, Luciene Barbosa de Sousa, Virgínia Fernandes Moça Trevisani, Hellen Fuzzi, Luís Eduardo Coelho Andrade   +4 more
doaj   +1 more source

Tissue Resident Memory Cells: Friend or Foe?

Immunology, EarlyView.
Tissue‐resident memory T cells (TRM cells) are specialised immune cells in barrier tissues like the lungs, skin and gut, providing rapid host defence and tumour surveillance. Their retention and differentiation are regulated by molecules such as CD69, CD103 and TGF‐β. Dysregulation of TRM cells can lead to chronic activation, driving conditions such as
Chidimma F. Chude, Jude E. Uzonna, Janilyn Arsenio   +2 more
wiley   +1 more source

The Transcription Factor EGR2 Plays a Central Role in the Expansion and Function of TCRαβ+CD4−CD8− Double Negative T Cells in lpr Lupus Mice

Immunology, EarlyView.
The highly expanded TCRβ+ DNT cells in autoimmune‐prone B6/lpr mice are phenotypically and functionally different from the TCRβ+DNT cells of normal B6 mice. Conditional Egr2 deletion in B6/lpr mice not only reduces TCRβ+ DNT cell numbers but also tends to correct the phenotypic and functional abnormalities of DNT cells in B6/lpr mice. In addition, Egr2
Rujuan Dai, Zhuang Wang, Bettina Heid, Christopher M. Reilly, S. Ansar Ahmed   +4 more
wiley   +1 more source

Vaccination as a Promising Approach in Cardiovascular Risk Mitigation: Are We Ready to Embrace a Vaccine Strategy?

Biomolecules
Cardiovascular disease (CVD) remains a leading global health concern, with atherosclerosis being its principal cause. Standard CVD treatments primarily focus on mitigating cardiovascular (CV) risk factors through lifestyle changes and cholesterol ...
Georgios Tsioulos, Natalia G. Vallianou, Alexandros Skourtis, Maria Dalamaga, Evangelia Kotsi, Sofia Kargioti, Nikolaos Adamidis, Irene Karampela, Iordanis Mourouzis, Dimitris Kounatidis   +9 more
doaj   +1 more source