Results 61 to 70 of about 44,843 (259)
Anti‐Carbamylated Protein Antibodies Stabilize Carbamylated Histone H3 to Promote Synovial Activation and Neutrophil Extracellular Trap‐Mediated Bone Loss in Rheumatoid Arthritis
Arthritis &Rheumatology, EarlyView.Objective
Carbamylation, a nonenzymatic post‐translational modification, contributes to rheumatoid arthritis (RA) pathogenesis. Anti‐carbamylated protein antibodies (anti‐CarP) occur in around 50% of patients with RA and associate with greater joint damage. Neutrophil extracellular traps (NETs) are a major source of carbamylated autoantigens. We sought Shuichiro Nakabo, Norio Hanata, Eduardo Patino‐Martinez, Ronald Holewinski, Ana Barrera‐Vargas, Javier Merayo‐Chalico, Scott A. Coonrod, David A. Fox, Mariana J. Kaplan, Carmelo Carmona‐Rivera +9 morewiley +1 more sourceTestosterone Influence on Gene Expression in Lacrimal Glands of Mouse Models of Sjögren Syndrome [PDF]
, 2019 Purpose:
Sjögren syndrome is an autoimmune disorder that occurs almost exclusively in women and is associated with extensive inflammation in lacrimal tissue, an immune-mediated destruction and/or dysfunction of glandular epithelial cells, and a ...Kam, Wendy R., Lieberman, Scott M., Morthen, Mathias Kaurstad, Rahimi Darabad, Raheleh, Richards, Stephen M., Sullivan, David A., Tellefsen, Sara +6 morecore +2 more sourcesImmune Complexes Shape the Pathogenicity of Autoantibodies in Systemic Autoimmune Diseases: Insights From an FcγRIIIA‐Reporter Assay
Arthritis &Rheumatology, EarlyView.Objective
Immune complexes (ICs), formed by autoantigen and autoantibody, play a pathogenic role in systemic autoimmune diseases through stimulation of Fcγ receptors (FcγR). However, studies investigating bioactivity of circulating ICs across various diseases remain limited.Koji Suzuki, Masaru Takeshita, Yuki Imai, Hiroyuki Fukui, Kazunori Furuhashi, Kotaro Matsumoto, Jun Kikuchi, Keiko Yoshimoto, Yuko Kaneko +8 morewiley +1 more sourceDysregulated Levels of Circulating Autoantibodies against Neuronal and Nervous System Autoantigens in COVID-19 Patients
Diagnostics, 2023 Background: COVID-19 is a heterogenous disease resulting in long-term sequela in predisposed individuals. It is not uncommon that recovering patients endure non-respiratory ill-defined manifestations, including anosmia, and neurological and cognitive ...Yael Lavi, Aristo Vojdani, Gilad Halpert, Kassem Sharif, Yuri Ostrinski, Israel Zyskind, Miriam T Lattin, Jason Zimmerman, Jonathan I Silverberg, Avi Z Rosenberg, Yehuda Shoenfeld, Howard Amital +11 moredoaj +1 more sourceClock Genes Regulate Ca2+ Signaling and Mitochondrial Bioenergetics to Inhibit Sjögren Disease
Arthritis &Rheumatology, EarlyView.Objective
Although Ca2+ signaling and metabolism have been identified as key determinants for the development of Sjögren disease (SjD), the intricate connection between them and salivary gland physiology remains poorly understood. Methods
Fluorescence‐based Ca2+ imaging, RNA sequencing, and mitochondrial activity were used to investigate the effects of Viktor R. Drel, Manigandan Venkatesan, Rahul S. Jasrotia, Yuyang Sun, Viviane Nascimento da Conceicao, Neelanjan Vishnu, Shankara N. Varadarajan, Venugopal R. Bovilla, Rajender K. Motiani, Shobhan Gaddameedhi, Bibhuti B. Mishra, Muniswamy Madesh, Brij B. Singh +12 morewiley +1 more sourceVaccination as a Promising Approach in Cardiovascular Risk Mitigation: Are We Ready to Embrace a Vaccine Strategy?
BiomoleculesCardiovascular disease (CVD) remains a leading global health concern, with atherosclerosis being its principal cause. Standard CVD treatments primarily focus on mitigating cardiovascular (CV) risk factors through lifestyle changes and cholesterol ...Georgios Tsioulos, Natalia G. Vallianou, Alexandros Skourtis, Maria Dalamaga, Evangelia Kotsi, Sofia Kargioti, Nikolaos Adamidis, Irene Karampela, Iordanis Mourouzis, Dimitris Kounatidis +9 moredoaj +1 more sourcePeripheral blood biomarkers in multiple sclerosis. [PDF]
, 2015 Multiple sclerosis is the most common autoimmune disorder affecting the central nervous system. The heteroge-neity of pathophysiological processes in MS contributes to the highly variable course of the disease and unpre-dictable response to therapies ...Acheson, Achiron, Ada Francia, Agmon-Levin, Aktas, Alatab, Alexander, Amorini, Anderson, Antonella D'Ambrosio, Arbour, Arnson, Arrambide, Ascherio, Ascherio, Ascherio, Axtell, Bar-Or, Barkhof, Barkhof, Barteneva, Bartosik-Psujek, Berger, Bertolotto, Bertolotto, Bertolotto, Bianco, Bielekova, Biomarkers Definitions Working Group, Bittner, Bloomgren, Braun, Brettschneider, Brex, Browne, Burger, Bustamante, Bustamante, Buttmann, Buzas, Bălaşa, Cantorna, Carotenuto, Carson, Cermelli, Chabas, Chen, Ciusani, Clifford, Cocucci, Colombo, Comabella, Comabella, Comabella, Comabella, Comi, Confavreux, Correale, Corvol, Cox, Creeke, D'Aurizio, D'Souza, Dalmau, De Jager, De Jager, De Santis, Deisenhammer, Derfuss, Dhib-Jalbut, Distler, Doyle, Du, Egg, Ehling, Eikelenboom, Engelhardt, Esteller, Eulalio, Fabriek, Farrell, Fenoglio, Fialová, Fissolo, Fonalledas Perelló, Fox, Freedman, Friedman, Galboiz, Gandhi, Gao, Ge, Gianchecchi, Gilli, Gilli, Giovannoni, Goldberg, Goodin, Graber, Graber, Gresle, Gresle, Guo, Haak, Haller, Hanke, Harris, Hartung, Hayes, Hecker, Hecker, Hellerqvist, Hinson, Horstman, Huang, Huang, Hur, Inoue, Ioannidis, Jimenez, Johnson, Julien, Junker, Kacperska, Kallaur, Kamath, Kasper, Kayagaki, Keller, Kemppinen, Knox, Korn, Korteweg, Kuenz, Kuhle, Kurtzke, Kvistad, Kwon, Lai, Lalive, Laroni, Lassmann, Lassmann, Lau, Lemire, Leppert, Leray, Lewis, Liang, Lily, Lin, Lindberg, Linington, Liotta, Littman, Liu, Lolli, Lopatinskaya, Lopatinskaya, Losseff, Losseff, Losy, Lovett-Racke, Lowery-Nordberg, Lublin, Lublin, Lucchinetti, Lycke, Lünemann, Lünemann, Major, Malucchi, Marchi, Markiewicz, Markovic-Plese, Martinelli-Boneschi, Marzesco, Masuoka, Mayer, Mazzali, McDonald, Miller, Minagar, Minagar, Minagar, Minagar, Missler, Mitchell, Momen-Heravi, Morel, Moreno, Mowry, Munger, Muralidharan-Chari, Murugaiyan, Myers, Nelissen, Nelissen, Norling, O'Connell, O'Connell, Oliveira, Oliver, Opdenakker, Opsahl, Otaegui, Pachner, Pachner, Pachner, Paola Margutti, Papini, Park, Pawate, Pelajo, Pender, Petereit, Peterson, Petrocca, Poloni, Probstel, Qin, Qu, Quintana, Redell, Reder, Reindl, Reindl, Rieckmann, Rieder, Riverol, Romo-Tena, Rovaris, Rudick, Rudick, Rudick, Sadiq, Salama, Sato, Schwarz, Schwarz, Selmi, Semra, Sendid, Sharief, Sharief, Sharief, Sharief, Shaw, Sheremata, Sievers, Silber, Silvia Zamboni, Siman, Simona Pontecorvo, Simpson, Soldan, Soldan, Sospedra, Srivastava, Stewart, Stüve, Sundström, Sáenz-Cuesta, Sáenz-Cuesta, Tania Colasanti, Tao, Teunissen, Tintoré, Trabattoni, Trampe, Turiák, van Horssen, Varga, Vartanian, Verderio, Villoslada, Virtanen, Vogt, Vogt, Wandinger, Wang, Waschbisch, Waubant, Waubant, Waubant, Waubant, Weinstock-Guttman, Wekerle, Xiao, Yong, Yong, Yousry, Zahednasab, Zang, Zhang, Zhu, Zipp, Zisimopoulou, Zula +298 morecore +1 more sourceAutoreactivity vs autoimmunity: characteristics of autoantigen‐specific CD4 T‐cells in rheumatoid arthritis and health.
Arthritis &Rheumatology, Accepted Article.Background
CD4 T cells specific for citrullinated (cit)‐peptides are key players in RA immunopathogenesis. Characterising these cells and identifying features of healthy and RA‐associated autoreactivity will provide valuable insight into disease mechanisms and form the basis of immune state biomarkers to facilitate the next generation of RA treatments. James A. Stanway, Daniel Peters, Helen Waller, Jeremy Lakey, Henrique De Paula Lemos, Kristian Williams, Abbie Degnan, Julie Diboll, Abdul Mannan Baru, David Tough, Arthur G. Pratt, Catharien M.U. Hilkens, Amy E. Anderson, John D. Isaacs +13 morewiley +1 more source
