Results 1 to 10 of about 852,493 (343)

Integrative Single-Cell RNA-Seq and ATAC-Seq Analysis of Peripheral Mononuclear Cells in Patients With Ankylosing Spondylitis

Frontiers in Immunology, 2021
ObjectiveGenetic studies on ankylosing spondylitis (AS) have identified more than 100 pathogenic genes. Building a bridge between these genes and biologically targeted therapies is the current research hotspot.MethodsWe integrated single-cell assaying ...
Huixuan Xu, Haiyan Yu, Lixiong Liu, Hongwei Wu, Cantong Zhang, Wanxia Cai, Xiaoping Hong, Dongzhou Liu, Donge Tang, Yong Dai, Yong Dai   +10 more
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Screening Biomarkers for Systemic Lupus Erythematosus Based on Machine Learning and Exploring Their Expression Correlations With the Ratios of Various Immune Cells

Frontiers in Immunology, 2022
BackgroundSystemic lupus erythematosus (SLE) is an autoimmune illness caused by a malfunctioning immunomodulatory system. China has the second highest prevalence of SLE in the world, from 0.03% to 0.07%.
Yafang Zhong, Wei Zhang, Wei Zhang, Xiaoping Hong, Zhipeng Zeng, Yumei Chen, Shengyou Liao, Wanxia Cai, Yong Xu, Gang Wang, Dongzhou Liu, Donge Tang, Yong Dai   +12 more
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Integrating spatial transcriptomics with single-cell transcriptomics reveals a spatiotemporal gene landscape of the human developing kidney

Cell & Bioscience, 2022
Background Research on spatiotemporal gene landscape can provide insights into the spatial characteristics of human kidney development and facilitate kidney organoid cultivation.
Hongwei Wu, Fanna Liu, Yu Shangguan, Yane Yang, Wei Shi, Wenlong Hu, Zhipeng Zeng, Nan Hu, Xinzhou Zhang, Berthold Hocher, Donge Tang, Lianghong Yin, Yong Dai   +12 more
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Urinary metabolomic biomarker candidates for skeletal muscle wasting in patients with rheumatoid arthritis

Journal of Cachexia, Sarcopenia and Muscle, 2023
Background Rheumatoid arthritis (RA) is an autoimmune disease that affects the joints, leading to chronic synovial inflammation and local tissue destruction. Extra‐articular manifestations may also occur, such as changes in body composition.
Marianne S. Oliveira, Rafaela C.E. Santo, Jordana M.S. Silva, Paulo V.G. Alabarse, Claiton V. Brenol, Steve P. Young, Ricardo M. Xavier   +6 more
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Comparing DESI-MSI and MALDI-MSI Mediated Spatial Metabolomics and Their Applications in Cancer Studies

Frontiers in Oncology, 2022
Metabolic heterogeneity of cancer contributes significantly to its poor treatment outcomes and prognosis. As a result, studies continue to focus on identifying new biomarkers and metabolic vulnerabilities, both of which depend on the understanding of ...
Michelle Junyi He, Michelle Junyi He, Wenjun Pu, Xi Wang, Wei Zhang, Donge Tang, Yong Dai, Yong Dai   +7 more
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Comprehensive analysis of lysine crotonylation modification in patients with chronic renal failure

BMC Nephrology, 2021
Background Post-translational modifications (PTMs) are at the heart of many cellular signaling events, which changes the function of protein. Crotonylation, one of the most important and common PTMs, plays a crucial role in the regulation of various ...
Jiahuang Huang, Donge Tang, Fengping Zheng, Huixuan Xu, Yong Dai   +4 more
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Establishment of an induced pluripotent stem cell line SPHi001-A from a systemic lupus erythematosus patient combined with preeclampsia and psoriasis

Stem Cell Research, 2021
Systemic lupus erythematosus (SLE) is a heterogeneous, autoimmune disease that can affect multiple organs and systems such as skin, joints, kidneys, hematologic system or central nervous system.
Dandan Li, Xiaoping Hong, Weilong Li, Shuhui Meng, Haiyan Yu, Xinzhou Zhang, Cuihua Wang, Igor M. Samokhvalov, Dongzhou Liu, Donge Tang, Yong Dai   +10 more
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Integrated analysis of competing endogenous RNA networks in peripheral blood mononuclear cells of systemic lupus erythematosus

Journal of Translational Medicine, 2021
Background Systemic lupus erythematosus (SLE) is an autoimmune disease with a complicated pathogenesis, and its aetiology has not been clearly unveiled.
Wencong Song, Jie Qiu, Lianghong Yin, Xiaoping Hong, Weier Dai, Donge Tang, Dongzhou Liu, Yong Dai   +7 more
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Screening biomarkers for Sjogren’s Syndrome by computer analysis and evaluating the expression correlations with the levels of immune cells

Frontiers in Immunology, 2023
BackgroundSjögren’s syndrome (SS) is a systemic autoimmune disease that affects about 0.04-0.1% of the general population. SS diagnosis depends on symptoms, clinical signs, autoimmune serology, and even invasive histopathological examination.
Yafang Zhong, Wei Zhang, Wei Zhang, Wei Zhang, Dongzhou Liu, Zhipeng Zeng, Shengyou Liao, Wanxia Cai, Jiayi Liu, Lian Li, Xiaoping Hong, Donge Tang, Yong Dai   +12 more
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Proteomic analysis of lysine 2-hydroxyisobutyryl in SLE reveals protein modification alteration in complement and coagulation cascades and platelet activation Pathways

BMC Medical Genomics, 2023
Background Post-translational modifications (PTMs) are considered to be an important factor in the pathogenesis of Systemic lupus erythematosus (SLE).
Chaoying Kuang, Dandan Li, Xianqing Zhou, Hua Lin, Ruohan Zhang, Huixuan Xu, Shaoying Huang, Fang Tang, Fanna Liu, Donge Tang, Yong Dai   +10 more
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