Results 11 to 20 of about 9,605,298 (318)

Comprehensive analysis of lysine crotonylation modification in patients with chronic renal failure

BMC Nephrology, 2021
Background Post-translational modifications (PTMs) are at the heart of many cellular signaling events, which changes the function of protein. Crotonylation, one of the most important and common PTMs, plays a crucial role in the regulation of various ...
Jiahuang Huang, Donge Tang, Fengping Zheng, Huixuan Xu, Yong Dai   +4 more
doaj   +1 more source

Screening biomarkers for Sjogren’s Syndrome by computer analysis and evaluating the expression correlations with the levels of immune cells

Frontiers in Immunology, 2023
BackgroundSjögren’s syndrome (SS) is a systemic autoimmune disease that affects about 0.04-0.1% of the general population. SS diagnosis depends on symptoms, clinical signs, autoimmune serology, and even invasive histopathological examination.
Yafang Zhong, Wei Zhang, Wei Zhang, Wei Zhang, Dongzhou Liu, Zhipeng Zeng, Shengyou Liao, Wanxia Cai, Jiayi Liu, Lian Li, Xiaoping Hong, Donge Tang, Yong Dai   +12 more
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Integrated analysis of competing endogenous RNA networks in peripheral blood mononuclear cells of systemic lupus erythematosus

Journal of Translational Medicine, 2021
Background Systemic lupus erythematosus (SLE) is an autoimmune disease with a complicated pathogenesis, and its aetiology has not been clearly unveiled.
Wencong Song, Jie Qiu, Lianghong Yin, Xiaoping Hong, Weier Dai, Donge Tang, Dongzhou Liu, Yong Dai   +7 more
doaj   +1 more source

Assessment and personalised advice for fatigue in systemic lupus erythematosus using an innovative digital tool: the Lupus Expert system for the Assessment of Fatigue (LEAF) study

RMD Open, 2023
Background Fatigue is reported as the most prevalent symptom by patients with systemic lupus erythematosus (SLE). Fatigue management is complex due to its multifactorial nature.
Laurent Arnaud, Matteo Piga, Manuel Francisco Ugarte-Gil, Philippe Mertz, Luc Pijnenburg, Marina Rinagel, Lou Kawka, Juan-Camilo Sarmiento-Monroy, Sophie Geneton, Julien Blaess   +9 more
doaj   +1 more source

Proteomic analysis of lysine 2-hydroxyisobutyryl in SLE reveals protein modification alteration in complement and coagulation cascades and platelet activation Pathways

BMC Medical Genomics, 2023
Background Post-translational modifications (PTMs) are considered to be an important factor in the pathogenesis of Systemic lupus erythematosus (SLE).
Chaoying Kuang, Dandan Li, Xianqing Zhou, Hua Lin, Ruohan Zhang, Huixuan Xu, Shaoying Huang, Fang Tang, Fanna Liu, Donge Tang, Yong Dai   +10 more
doaj   +1 more source

The Chromatin Accessibility Landscape of Peripheral Blood Mononuclear Cells in Patients With Systemic Lupus Erythematosus at Single-Cell Resolution

Frontiers in Immunology, 2021
ObjectiveSystemic lupus erythematosus (SLE) is a complex autoimmune disease, and various immune cells are involved in the initiation, progression, and regulation of SLE.
Haiyan Yu, Haiyan Yu, Xiaoping Hong, Hongwei Wu, Fengping Zheng, Zhipeng Zeng, Weier Dai, Lianghong Yin, Dongzhou Liu, Donge Tang, Yong Dai   +10 more
doaj   +1 more source

B cell depletion therapies in autoimmune disease: advances and mechanistic insights

Nature reviews. Drug discovery, 2020
In the past 15 years, B cells have been rediscovered to be not merely bystanders but rather active participants in autoimmune aetiology. This has been fuelled in part by the clinical success of B cell depletion therapies (BCDTs).
Dennis S. W. Lee, Olga L. Rojas, J. Gommerman   +2 more
semanticscholar   +1 more source

The characteristics of extrachromosomal circular DNA in patients with end-stage renal disease

European Journal of Medical Research, 2023
Background End-stage renal disease (ESRD) is the final stage of chronic kidney disease (CKD). In addition to the structurally intact chromosome genomic DNA, there is a double-stranded circular DNA called extrachromosomal circular DNA (eccDNA), which is ...
Yue Peng, Yixi Li, Wei Zhang, Yu ShangGuan, Ting Xie, Kang Wang, Jing Qiu, Wenjun Pu, Biying Hu, Xinzhou Zhang, Lianghong Yin, Donge Tang, Yong Dai   +12 more
doaj   +1 more source

Absolute quantification and characterization of oxylipins in lupus nephritis and systemic lupus erythematosus

Frontiers in Immunology, 2022
Systemic lupus erythematosus (SLE) is a chronic autoimmune disease with multi-organ inflammation and defect, which is linked to many molecule mediators. Oxylipins as a class of lipid mediator have not been broadly investigated in SLE.
Jingquan He, Jingquan He, Chiyu Ma, Donge Tang, Shaoyun Zhong, Xiaofang Yuan, Fengping Zheng, Zhipeng Zeng, Yumei Chen, Dongzhou Liu, Xiaoping Hong, Weier Dai, Lianghong Yin, Yong Dai   +13 more
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Systematic proteomics profiling of lysine crotonylation of the lung at Pseudoglandular and Canalicular phases in human fetus

Proteome Science, 2023
Lung tissue is an important organ of the fetus, and genomic research on its development has improved our understanding of the biology of this tissue. However, the proteomic research of developing fetal lung tissue is still very scarce.
Wei Wang, Wei Shi, Yinglan Wang, Yane Yang, Ping Li, Zhipeng Zeng, Wenlong Hu, Yumei Chen, Donge Tang, Yong Dai   +9 more
doaj   +1 more source