Results 51 to 60 of about 9,492,165 (393)

Quality of life in mild and severe alopecia areata patients

International Journal of Women's Dermatology, 2018
Background: Alopecia areata is a relapsing hair disorder characterized by a sudden hairloss and has a considerable impact on patient’s quality of life. The goal of this study was to determine quality of life among patients with mild and severe forms of ...
Robabeh Abedini, Zahra Hallaji, Vahideh Lajevardi, Maryam Nasimi, Mona Karimi Khaledi, Hamid Reza Tohidinik   +5 more
doaj   +1 more source

Eosinophils in Autoimmune Diseases [PDF]

Frontiers in Immunology, 2017
Eosinophils are multifunctional granulocytes that contribute to initiation and modulation of inflammation. Their role in asthma and parasitic infections has long been recognized. Growing evidence now reveals a role for eosinophils in autoimmune diseases.
Diny, Nicola L., Rose, Noel R., Čiháková, Daniela   +2 more
openaire   +5 more sources

Leveraging current insights on IL‐10‐producing dendritic cells for developing effective immunotherapeutic approaches

FEBS Letters, EarlyView.
In vivo IL‐10 produced by tissue‐resident tolDC is involved in maintaining/inducing tolerance. Depending on the agent used for ex vivo tolDC generation, cells acquire common features but prime T cells towards anergy, FOXP3+ Tregs, or Tr1 cells according to the levels of IL‐10 produced. Ex vivo‐induced tolDC were administered to patients to re‐establish/
Konstantina Morali, Gloria Giacomello, Michela Vuono, Silvia Gregori   +3 more
wiley   +1 more source

graph-GPA 2.0: A Graphical Model for Multi-disease Analysis of GWAS Results with Integration of Functional Annotation Data [PDF]

arXiv, 2022
Genome-wide association studies (GWAS) have successfully identified a large number of genetic variants associated with traits and diseases. However, it still remains challenging to fully understand functional mechanisms underlying many associated variants. This is especially the case when we are interested in variants shared across multiple phenotypes.
arxiv  

Limited statistical evidence for shared genetic effects of eQTLs and autoimmune disease-associated loci in three major immune cell types

Nature Genetics, 2017
Most autoimmune-disease-risk effects identified by genome-wide association studies (GWAS) localize to open chromatin with gene-regulatory activity. GWAS loci are also enriched in expression quantitative trait loci (eQTLs), thus suggesting that most risk ...
S. Chun, Alexandra Casparino, N. Patsopoulos, Damien C. Croteau-Chonka, B. Raby, P. D. De Jager, S. Sunyaev, C. Cotsapas   +7 more
semanticscholar   +1 more source

Insights into PI3K/AKT signaling in B cell development and chronic lymphocytic leukemia

FEBS Letters, EarlyView.
This Review explores how the phosphoinositide 3‐kinase and protein kinase B pathway shapes B cell development and drives chronic lymphocytic leukemia, a common blood cancer. It examines how signaling levels affect disease progression, addresses treatment challenges, and introduces novel experimental strategies to improve therapies and patient outcomes.
Maike Buchner
wiley   +1 more source

Disease predisposition of human leukocyte antigen class II genes influences the gut microbiota composition in patients with primary biliary cholangitis

Frontiers in Immunology, 2022
BackgroundThe human leukocyte antigen (HLA) susceptibility gene is the main genetic risk factor for primary biliary cholangitis (PBC). The prognosis of patients with PBC is linked to gut microbiota dysbiosis.
Chun-Yang Huang, Hai-Ping Zhang, Wei-Jia Han, Dan-Tong Zhao, Hui-Yu Liao, Yin-Xue Ma, Bin Xu, Li-Juan Li, Ying Han, Xiu-Hong Liu, Qi Wang, Jin-Li Lou, Xiao-Dan Zhang, Juan Zhao, Wen-Juan Li, Yan-Min Liu, Hui-Ping Yan, Hui-Ping Yan   +17 more
doaj   +1 more source

Glassy Dynamics in the Adaptive Immune Response Prevents Autoimmune Disease [PDF]

, 2005
The immune system normally protects the human host against death by infection. However, when an immune response is mistakenly directed at self antigens, autoimmune disease can occur. We describe a model of protein evolution to simulate the dynamics of the adaptive immune response to antigens.
arxiv   +1 more source

The dual role of short fatty acid chains in the pathogenesis of autoimmune disease models

PLoS ONE, 2017
Autoimmune diseases are influenced by both genetic and environmental factors. The gut environment has attracted much attention as an essential component that modulates immune responses, and therefore immune-mediated disorders, such as autoimmune diseases.
M. Mizuno, D. Noto, N. Kaga, A. Chiba, S. Miyake   +4 more
semanticscholar   +1 more source

The power of microRNA regulation—insights into immunity and metabolism

FEBS Letters, EarlyView.
MicroRNAs are emerging as crucial regulators at the intersection of metabolism and immunity. This review examines how miRNAs coordinate glucose and lipid metabolism while simultaneously modulating T‐cell development and immune responses. Moreover, it highlights how cutting‐edge artificial intelligence applications can identify miRNA biomarkers ...
Stefania Oliveto, Nicola Manfrini, Stefano Biffo   +2 more
wiley   +1 more source