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The role of macrophage subpopulations in autoimmune disease of the central nervous system
The Histochemical Journal, 1996In this review the role of various subpopulations of macrophages in the pathogenesis of experimental autoimmune encephalomyetitis is discussed. Immunohistochemistry with macrophage markers shows that in this disease different populations of macrophages (i.e.
J, Bauer +3 more
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Contribution of the Enteric Nervous System to Autoimmune Diseases and Irritable Bowel Syndrome
2022Anti-neuronal autoantibodies can lead to subacute gastrointestinal dysmotility, presenting with various symptoms typical of intestinal pseudoobstruction, achalasia, gastroparesis, or slow intestinal transit, among others. Such autoantibodies may be produced in response to a remote tumor and accelerate the diagnosis of malignancy, but in other cases ...
Anita, Annaházi, Michael, Schemann
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Role of CD8 T-Cell-Mediated Autoimmune Diseases of the Central Nervous System
Critical Reviews™ in Immunology, 2010In T-cell-mediated autoimmune diseases of the central nervous system (CNS), CD4 T cells have long been regarded as the only pathogenetically relevant T-cell population. However, growing clinical and experimental evidence suggests that CD8 T cells also contribute significantly to autoimmune responses in the CNS.
Martina, Deckert +3 more
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Neuromyelitis optica (NMO)--an autoimmune disease of the central nervous system (CNS).
Acta neurologica Scandinavica, 2010In the past 10 years, neuromyelitis optica (NMO) has evolved from Devic's categorical clinical description into a broader disease spectrum. Serum IgG antibodies have been identified in NMO patients with the water channel aquaporin-4 (AQP4) as their main target antigen.
Asgari, N +5 more
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Approaches to the treatment of central nervous system autoimmune disease using specific neuroantigen
Immunology & Cell Biology, 1998The ultimate aim in the treatment of autoimmune disease is to restore self‐tolerance to the autoantigen(s) in question. In lieu of this ideal result, the conversion of a destructive or pathogenic autoimmune response into one of benign autoimmunity would also be highly desirable.
D O, Willenborg, M A, Staykova
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The Role of Astrocytes in Autoimmune Disease of the Central Nervous System
2008Astrocytes are the most abundant glial cell population in the central nervous system (CNS). In the healthy brain and spinal cord, the major function of astrocytes includes the formation and maintenance of the blood brain barrier (BBB), and the supply of structural support and nourishment to neurons.
Olaf Stüve, Scott S. Zamvil
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Human Stem Cell–Derived Models: Lessons for Autoimmune Diseases of the Nervous System
The Neuroscientist, 2018Autoimmunity of the peripheral and central nervous system is an important cause of disease and long-term neurological disability. Autoantibodies can target both intracellular and extracellular neuronal epitopes. Autoantibodies that target cell-surface epitopes infer pathogenicity through several distinct mechanisms, while patients often respond to ...
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P18.9 Autoimmune demyelinating diseases of the nervous system
Clinical Neurophysiology, 2011I. López Gutiérrez +6 more
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Gene therapy for autoimmune demyelinating disease of the central nervous system.
Archivum immunologiae et therapiae experimentalis, 2001Gene therapy is currently being explored as a new therapeutic treatment of autoimmune disease. The genetic modification of autoreactive memory T cells (T cell-mediated gene therapy) and autoimmune target tissue (target tissue gene therapy) to produce immunoregulatory cytokines offers a promising way to regulate autoimmunity.
P M, Mathisen, V K, Tuohy
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Autoimmune Diseases of the Central Nervous System in Childhood
Journal of Pediatric Neurology, 2017Brenda Banwell, J. Brenton
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