Results 1 to 10 of about 153,226 (196)
Journal of Diabetes Research, 2022 Background. Type 1 diabetes (T1D) occurs as a result of insulin deficiency due to destructive lesions of pancreatic β cells. In addition to classical autoantibodies (Abs) to islet cell antigens, antizinc transporter 8 Abs (ZnT8-Ab) have been recently ...
Raouia Fakhfakh +8 more
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CARD10 cleavage by MALT1 restricts lung carcinoma growth in vivo
Oncogenesis, 2021 CARD-CC complexes involving BCL10 and MALT1 are major cellular signaling hubs. They govern NF-κB activation through their scaffolding properties as well as MALT1 paracaspase function, which cleaves substrates involved in NF-κB regulation.
Laura Israël +17 more
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Nature Reviews Gastroenterology & Hepatology, 1996 Autoimmune hepatitis is an inflammatory liver disease in which the immune system is believed to orchestrate an immune attack onto the liver cell. Current knowledge suggests that both T helper 1 (TH1) and TH2 programmes are involved in the generation of the liver damage.
Vergani, D, Mieli-Vergani, G
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Autoimmunity and Parasites [PDF]
International Journal of Immunopathology and Pharmacology, 2008 n ...
Papazahariadou M +13 more
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New Clinical Phenotype of the Post-Covid Syndrome: Fibromyalgia and Joint Hypermobility Condition
Pathophysiology, 2022 Fibromyalgia can be defined as a chronic pain condition, affecting the musculoskeletal system, etiology and pathophysiology of which is sufficiently understudied.
Natalia Gavrilova +6 more
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Seminars in Immunopathology, 2021 AbstractThe thymus prevents autoimmune diseases through mechanisms that operate in the cortex and medulla, comprising positive and negative selection and the generation of regulatory T-cells (Tregs). Egress from the thymus through the perivascular space (PVS) to the blood is another possible checkpoint, as shown by some autoimmune/immunodeficiency ...
Yosuke Yamada +7 more
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Scientific Reports, 2021 Systemic lupus erythematosus (SLE) is an autoimmune disease where bone-marrow-derived haematopoietic cells have a key role in its pathogenesis with accumulating evidence suggesting an aberrant function of haematopoietic stem/progenitor cells (HSPCs).
Ioannis Kokkinopoulos +9 more
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Atherosclerosis and Autoimmunity [PDF]
Mediators of Inflammation, 2018 Abstract Despite a decline in mortality rates in several countries, cardiovascular disease remains the leading cause of death responsible for approximately half of all deaths on the continent. Coronary artery disease and stroke are often the result of acute complications of atherosclerosis (AS) and atherothrombosis.
Francesca Romana Spinelli +4 more
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CD4+-mediated colitis in mice is independent of the GPR183 and GPR18 pathways
Frontiers in Immunology, 2022 Colitis is characterized by an exacerbated intestinal immune response, but the genetic and other mechanisms regulating immune activation remain incompletely understood.
Martina Dicker +11 more
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STIM1 at the plasma membrane as a new target in progressive chronic lymphocytic leukemia
Journal for ImmunoTherapy of Cancer, 2019 Background Dysregulation in calcium (Ca2+) signaling is a hallmark of chronic lymphocytic leukemia (CLL). While the role of the B cell receptor (BCR) Ca2+ pathway has been associated with disease progression, the importance of the newly described ...
Marjolaine Debant +14 more
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