Results 1 to 10 of about 148,813 (149)
Journal of Diabetes Research, 2022 Background. Type 1 diabetes (T1D) occurs as a result of insulin deficiency due to destructive lesions of pancreatic β cells. In addition to classical autoantibodies (Abs) to islet cell antigens, antizinc transporter 8 Abs (ZnT8-Ab) have been recently ...
Raouia Fakhfakh +8 more
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CARD10 cleavage by MALT1 restricts lung carcinoma growth in vivo
Oncogenesis, 2021 CARD-CC complexes involving BCL10 and MALT1 are major cellular signaling hubs. They govern NF-κB activation through their scaffolding properties as well as MALT1 paracaspase function, which cleaves substrates involved in NF-κB regulation.
Laura Israël +17 more
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New Clinical Phenotype of the Post-Covid Syndrome: Fibromyalgia and Joint Hypermobility Condition
Pathophysiology, 2022 Fibromyalgia can be defined as a chronic pain condition, affecting the musculoskeletal system, etiology and pathophysiology of which is sufficiently understudied.
Natalia Gavrilova +6 more
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Scientific Reports, 2021 Systemic lupus erythematosus (SLE) is an autoimmune disease where bone-marrow-derived haematopoietic cells have a key role in its pathogenesis with accumulating evidence suggesting an aberrant function of haematopoietic stem/progenitor cells (HSPCs).
Ioannis Kokkinopoulos +9 more
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CD4+-mediated colitis in mice is independent of the GPR183 and GPR18 pathways
Frontiers in Immunology, 2022 Colitis is characterized by an exacerbated intestinal immune response, but the genetic and other mechanisms regulating immune activation remain incompletely understood.
Martina Dicker +11 more
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STIM1 at the plasma membrane as a new target in progressive chronic lymphocytic leukemia
Journal for ImmunoTherapy of Cancer, 2019 Background Dysregulation in calcium (Ca2+) signaling is a hallmark of chronic lymphocytic leukemia (CLL). While the role of the B cell receptor (BCR) Ca2+ pathway has been associated with disease progression, the importance of the newly described ...
Marjolaine Debant +14 more
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Diagnostics, 2023 Anti-neutrophil cytoplasmic antibodies (ANCA) directed to proteinase 3 (PR3) represent highly established markers for patients with ANCA-associated vasculitis (AAV). PR3-ANCA have also demonstrated utility in the management of inflammatory bowel disease (
Carmen Andalucía +5 more
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dcHiC detects differential compartments across multiple Hi-C datasets
Nature Communications, 2022 The organisation of mammalian genomes plays a role in many biological processes. Here the authors report dcHiC, a tool which uses a multivariate distance measure to identify changes in compartmentalisation among multiple genome-wide chromatin contact ...
Abhijit Chakraborty +2 more
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Journal of Clinical and Translational Science, 2021 IMPACT: Better understanding of the factors impacting disease severity and immunological response of MS patients on disease modifying therapy will enable better recommendations for vaccination options and risk mitigation strategies OBJECTIVES/GOALS: The ...
Ahya S Ali, Yang Mao-Draayer
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Pathogenic mechanisms of IgE-mediated inflammation in self-destructive autoimmune responses
Autoimmunity, 2017 Autoantibodies of the IgG subclass are pathogenic in a number of autoimmune disorders such as systemic lupus erythomatosus. The presence of circulating IgE autoantibodies in autoimmune patients has also been known for almost 40 years.
Rachel Ettinger +6 more
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