Results 11 to 20 of about 339,261 (412)

NF-κB: At the Borders of Autoimmunity and Inflammation

Frontiers in Immunology, 2021
The transcription factor NF-κB regulates multiple aspects of innate and adaptive immune functions and serves as a pivotal mediator of inflammatory response.
L. Barnabei, E. Laplantine, William Mbongo, F. Rieux-Laucat, R. Weil   +4 more
semanticscholar   +1 more source

Autoimmunity is a hallmark of post-COVID syndrome

Journal of Translational Medicine, 2022
Autoimmunity has emerged as a characteristic of the post-COVID syndrome (PCS), which may be related to sex. In order to further investigate the relationship between SARS-CoV-2 and autoimmunity in PCS, a clinical and serological assessment on 100 patients
M. Rojas, Yhojan Rodríguez, Y. Acosta-Ampudia, D. Monsalve, Chengsong Zhu, Quanzhen Li, C. Ramírez-Santana, J. Anaya   +7 more
semanticscholar   +1 more source

Autoantibodies to Zinc Transporter 8 and SLC30A8 Genotype in Type 1 Diabetes Childhood: A Pioneering Study in North Africa

Journal of Diabetes Research, 2022
Background. Type 1 diabetes (T1D) occurs as a result of insulin deficiency due to destructive lesions of pancreatic β cells. In addition to classical autoantibodies (Abs) to islet cell antigens, antizinc transporter 8 Abs (ZnT8-Ab) have been recently ...
Raouia Fakhfakh, Sana Kmiha, Safa Tahri, Sawsan Feki, Ferjeni Zouidi, Olfa Abida, Mongia Hachicha, Thouraya Kammoun, Hatem Masmoudi   +8 more
doaj   +1 more source

CARD10 cleavage by MALT1 restricts lung carcinoma growth in vivo

Oncogenesis, 2021
CARD-CC complexes involving BCL10 and MALT1 are major cellular signaling hubs. They govern NF-κB activation through their scaffolding properties as well as MALT1 paracaspase function, which cleaves substrates involved in NF-κB regulation.
Laura Israël, Anton Glück, Marjorie Berger, Marine Coral, Melanie Ceci, Adeline Unterreiner, Joëlle Rubert, Maureen Bardet, Stefanie Ginster, Alexandra M. Golding-Ochsenbein, Kea Martin, Thomas Hoyler, Thomas Calzascia, Grazyna Wieczorek, Rainer Hillenbrand, Stéphane Ferretti, Enrico Ferrero, Frédéric Bornancin   +17 more
doaj   +1 more source

Heterologous autoimmunity and prokaryotic immune defense [PDF]

Current Biology 2022, 2021
Some prokaryotes possess CRISPR-Cas systems that provide adaptive immunity to viruses guided by DNA segments called spacers acquired from invading phage. However, the patchy incidence and limited memory breadth of CRISPR-Cas systems suggest that their fitness benefits are offset by costs.
arxiv   +1 more source

New Clinical Phenotype of the Post-Covid Syndrome: Fibromyalgia and Joint Hypermobility Condition

Pathophysiology, 2022
Fibromyalgia can be defined as a chronic pain condition, affecting the musculoskeletal system, etiology and pathophysiology of which is sufficiently understudied.
Natalia Gavrilova, Lidiia Soprun, Maria Lukashenko, Varvara Ryabkova, Tamara V. Fedotkina, Leonid P. Churilov, Yehuda Shoenfeld   +6 more
doaj   +1 more source

IL-6 in inflammation, autoimmunity and cancer

International Immunology, 2020
IL-6: a nexus for immune responses and ...
T. Hirano
semanticscholar   +1 more source

The intersection of COVID-19 and autoimmunity.

Journal of Clinical Investigation, 2021
Acute coronavirus disease 2019 (COVID-19), caused by SARS-CoV-2, is characterized by diverse clinical presentations, ranging from asymptomatic infection to fatal respiratory failure, and often associated with varied longer-term sequelae. Over the past 18
J. Knight, R. Caricchio, J. Casanova, A. Combes, B. Diamond, S. Fox, D. Hanauer, J. James, Y. Kanthi, Virginia Ladd, P. Mehta, A. Ring, I. Sanz, C. Selmi, R. Tracy, P. Utz, Catriona A Wagner, Julia Y. Wang, W. Mccune   +18 more
semanticscholar   +1 more source

Patrolling human SLE haematopoietic progenitors demonstrate enhanced extramedullary colonisation; implications for peripheral tissue injury

Scientific Reports, 2021
Systemic lupus erythematosus (SLE) is an autoimmune disease where bone-marrow-derived haematopoietic cells have a key role in its pathogenesis with accumulating evidence suggesting an aberrant function of haematopoietic stem/progenitor cells (HSPCs).
Ioannis Kokkinopoulos, Aggelos Banos, Maria Grigoriou, Anastasia Filia, Theodora Manolakou, Themis Alissafi, Nikolaos Malissovas, Ioannis Mitroulis, Panayotis Verginis, Dimitrios T. Boumpas   +9 more
doaj   +1 more source

CD4+-mediated colitis in mice is independent of the GPR183 and GPR18 pathways

Frontiers in Immunology, 2022
Colitis is characterized by an exacerbated intestinal immune response, but the genetic and other mechanisms regulating immune activation remain incompletely understood.
Martina Dicker, Yingcong Li, Yingcong Li, Daniel A. Giles, Greet Verstichel, Viankail Cedillo Castelan, Gabriel Ascui-Gac, Ting-Fang Chou, Tamara Perez-Jeldres, Hilde Cheroutre, Mitchell Kronenberg, Mitchell Kronenberg   +11 more
doaj   +1 more source