Results 41 to 50 of about 207,009 (370)
Cell Transplantation, 2013 Islet grafts can contribute to their own destruction via the elaboration of proinflammatory genes, many of which are transcriptionally regulated by nuclear factor κ-light-chain-enhancer of activated B-cells (NF-κB).
Nathan W. Zammit +6 more
doaj +1 more source
Viruses and Autoimmunity: A Review on the Potential Interaction and Molecular Mechanisms
Viruses, 2019 For a long time, viruses have been shown to modify the clinical picture of several autoimmune diseases, including type 1 diabetes (T1D), systemic lupus erythematosus (SLE), rheumatoid arthritis (RA), Sjögren’s syndrome (SS), herpetic stromal keratitis ...
M. Smatti +5 more
semanticscholar +1 more source
Pathophysiology, 2021 Chronic pain may affect 30–50% of the world’s population and an important cause is small fiber neuropathy (SFN). Recent research suggests that autoimmune diseases may be one of the most common causes of small nerve fiber damage. There is low awareness of
Mariia V. Lukashenko +7 more
doaj +1 more source
CD38: An Immunomodulatory Molecule in Inflammation and Autoimmunity
Frontiers in Immunology, 2020 CD38 is a molecule that can act as an enzyme, with NAD-depleting and intracellular signaling activity, or as a receptor with adhesive functions. CD38 can be found expressed either on the cell surface, where it may face the extracellular milieu or the ...
Z. Piedra-Quintero +3 more
semanticscholar +1 more source
IL-21 drives expansion and plasma cell differentiation of autoreactive CD11chiT-bet+ B cells in SLE
Nature Communications, 2018 Systemic lupus erythematosus (SLE) is associated with altered B cell responses but the underlying aetiology is still unclear. Here the authors show that a CD11chiT-bet+ B cell subset with a unique phenotype and transcriptome is increased in patients with
Shu Wang +21 more
doaj +1 more source
Molecular Medicine, 2016 The goal of this study was to determine how B-cell-activating factor of the TNF family (BAFF) availability influences selection of the autoreactive B-cell repertoire in NZB/W and NZW/BXSB lupus-prone mice bearing the site-directed heavy-chain transgene ...
Alexis Boneparth +5 more
doaj +1 more source
Clinical & Translational Immunology, 2021 Autoimmunity plays a significant role in the pathogenesis of demyelination. Multiple sclerosis (MS), neuromyelitis optica spectrum disorders (NMOSD) and myelin oligodendrocyte glycoprotein antibody‐associated disease (MOGAD) are now recognised as ...
Joseph A Lopez +4 more
doaj +1 more source
Implications of macrophage polarization in autoimmunity
Immunology, 2018 Macrophages are extremely heterogeneous and plastic cells with an important role not only in physiological conditions, but also during inflammation (both for initiation and resolution).
S. C. Funes +3 more
semanticscholar +1 more source
Science Translational Medicine, 2020 Gut microbiota dysbiosis induces lupus-like autoimmunity in mice through altered tryptophan catabolism. The advantage of reducing dietary tryptophan Alterations in the gut microbiota may contribute to autoimmunity through bacterial-mediated immune ...
Seung-Chul Choi +10 more
semanticscholar +1 more source
A nonconservative kinetic model under the action of an external force field for modeling the medical treatment of autoimmune response [PDF]
, 2023 In this paper, we develop a new nonconservative kinetic framework to be applied for the study of immune system dysregulation. From the modeling viewpoint, the new kinetic model regards a system, composed of stochastically interacting agents, under the action of an eternal force field.
arxiv +1 more source