Results 41 to 50 of about 349,570 (384)

Acute cigarette smoke exposure activates apoptotic and inflammatory programs but a second stimulus is required to induce epithelial to mesenchymal transition in COPD epithelium

Respiratory Research, 2017
Background Smoking and aberrant epithelial responses are risk factors for lung cancer as well as chronic obstructive pulmonary disease and idiopathic pulmonary fibrosis.
Lynne A. Murray, Rebecca Dunmore, Ana Camelo, Carla A. Da Silva, Malin J. Gustavsson, David M. Habiel, Tillie L Hackett, Cory M. Hogaboam, Matthew A. Sleeman, Darryl A. Knight   +9 more
doaj   +1 more source

CD28 between tolerance and autoimmunity: The side effects of animal models [version 1; referees: 2 approved] [PDF]

, 2018
Regulation of immune responses is critical for ensuring pathogen clearance and for preventing reaction against self-antigens. Failure or breakdown of immunological tolerance results in autoimmunity.
A Aruffo, A Levine, A Paterson, A Schneider, B Salomon, C Brunstein, C Camperio, C Dendrou, C Lin, C Peterfy, D Franckaert, D Tyrsin, E Hui, E Mayer, F Lühder, G Burmester, G Freeman, G Suntharalingam, H Gmünder, H Ko, I McInnes, I Vogel, J Esensten, J Gross, J Kremer, J Vahl, K Haanstra, M Kishore, M Kunkl, M Tacke, M Vierboom, M Wagner, N Beyersdorf, N Dilek, N Ohkura, N Poirier, N Porciello, N Porciello, O Acuto, P Emery, P Linsley, P Martin, P Tabares, Q Zhang, R Westhovens, R Westhovens, R Zhang, R Zhang, R Zhang, S Bhela, S Khoury, S Weißmüller, S Yao, T Hünig, T Hünig, T Thauland, T Thaventhiran, X He   +57 more
core   +2 more sources

Viruses and Autoimmunity: A Review on the Potential Interaction and Molecular Mechanisms

Viruses, 2019
For a long time, viruses have been shown to modify the clinical picture of several autoimmune diseases, including type 1 diabetes (T1D), systemic lupus erythematosus (SLE), rheumatoid arthritis (RA), Sjögren’s syndrome (SS), herpetic stromal keratitis ...
M. Smatti, F. Cyprian, Gheyath K Nasrallah, A. A. Al Thani, Ruba Almishal, H. Yassine   +5 more
semanticscholar   +1 more source

Low-Dose Rapamycin Unmasks the Protective Potential of Targeting Intragraft NF-κB for Islet Transplants

Cell Transplantation, 2013
Islet grafts can contribute to their own destruction via the elaboration of proinflammatory genes, many of which are transcriptionally regulated by nuclear factor κ-light-chain-enhancer of activated B-cells (NF-κB).
Nathan W. Zammit, Bernice M. Tan, Stacey N. Walters, David Liuwantara, Jeanette E. Villanueva, Elisabeth K. Malle, Shane T. Grey   +6 more
doaj   +1 more source

Letter to the editor: autoimmune pathogenic mechanisms in amyotrophic lateral sclerosis [PDF]

, 2018
The innate immune system may affect the function and survival of motor neurons in ALS by at least three mechanisms. First, there is evidence to suggest that aggregates of mutant SOD1—which is derived from microglial and astroglial cells—activate ...
de Vincentiis, M., De Virgilio, A., Gallo, A., Greco, A., Inghilleri, M., Ralli, M.   +5 more
core   +1 more source

Gut microbiota dysbiosis and altered tryptophan catabolism contribute to autoimmunity in lupus-susceptible mice

Science Translational Medicine, 2020
Gut microbiota dysbiosis induces lupus-like autoimmunity in mice through altered tryptophan catabolism. The advantage of reducing dietary tryptophan Alterations in the gut microbiota may contribute to autoimmunity through bacterial-mediated immune ...
Seung-Chul Choi, Josephine Brown, Minghao Gong, Yong Ge, M. Zadeh, Wei Li, B. Croker, G. Michailidis, T. Garrett, M. Mohamadzadeh, L. Morel   +10 more
semanticscholar   +1 more source

Audio-vestibular symptoms in systemic autoimmune diseases [PDF]

, 2018
Immune-mediated inner ear disease can be primary, when the autoimmune response is against the inner ear, or secondary. The latter is characterized by the involvement of the ear in the presence of systemic autoimmune conditions. Sensorineural hearing loss
Adelchi, Croce, D'AGUANNO, VITTORIO, DE VINCENTIIS, Marco, DE VIRGILIO, ARMANDO, DI STADIO, Arianna, GRECO, Antonio, LONGO, Lucia, RALLI, MASSIMO   +7 more
core   +1 more source

IL-21 drives expansion and plasma cell differentiation of autoreactive CD11chiT-bet+ B cells in SLE

Nature Communications, 2018
Systemic lupus erythematosus (SLE) is associated with altered B cell responses but the underlying aetiology is still unclear. Here the authors show that a CD11chiT-bet+ B cell subset with a unique phenotype and transcriptome is increased in patients with
Shu Wang, Jingya Wang, Varsha Kumar, Jodi L. Karnell, Brian Naiman, Phillip S. Gross, Saifur Rahman, Kamelia Zerrouki, Richard Hanna, Christopher Morehouse, Nicholas Holoweckyj, Hao Liu, Autoimmunity Molecular Medicine Team, Zerai Manna, Raphaela Goldbach-Mansky, Sarfaraz Hasni, Richard Siegel, Miguel Sanjuan, Katie Streicher, Michael P. Cancro, Roland Kolbeck, Rachel Ettinger   +21 more
doaj   +1 more source

The Effect of BAFF Inhibition on Autoreactive B-Cell Selection in Murine Systemic Lupus Erythematosus

Molecular Medicine, 2016
The goal of this study was to determine how B-cell-activating factor of the TNF family (BAFF) availability influences selection of the autoreactive B-cell repertoire in NZB/W and NZW/BXSB lupus-prone mice bearing the site-directed heavy-chain transgene ...
Alexis Boneparth, Megan Woods, Weiqing Huang, Meredith Akerman, Martin Lesser, Anne Davidson   +5 more
doaj   +1 more source

Pathogenesis of autoimmune demyelination: from multiple sclerosis to neuromyelitis optica spectrum disorders and myelin oligodendrocyte glycoprotein antibody‐associated disease

Clinical & Translational Immunology, 2021
Autoimmunity plays a significant role in the pathogenesis of demyelination. Multiple sclerosis (MS), neuromyelitis optica spectrum disorders (NMOSD) and myelin oligodendrocyte glycoprotein antibody‐associated disease (MOGAD) are now recognised as ...
Joseph A Lopez, Martina Denkova, Sudarshini Ramanathan, Russell C Dale, Fabienne Brilot   +4 more
doaj   +1 more source