Results 41 to 50 of about 153,226 (196)

Loop Catalog: a comprehensive HiChIP database of human and mouse samples

Genome Biology
HiChIP enables cost-effective and high-resolution profiling of chromatin loops. To leverage the increasing number of HiChIP datasets, we develop Loop Catalog ( https://loopcatalog.lji.org ), a web-based database featuring loop calls from over 1000 ...
Joaquin Reyna, Kyra Fetter, Romeo Ignacio, Cemil Can Ali Marandi, Astoria Ma, Nikhil Rao, Zichen Jiang, Daniela Salgado Figueroa, Sourya Bhattacharyya, Ferhat Ay   +9 more
doaj   +1 more source

A unique role for galectin-9 in angiogenesis and inflammatory arthritis

Arthritis Research & Therapy, 2018
Background Galectin-9 (Gal-9) is a mammalian lectin secreted by endothelial cells that is highly expressed in rheumatoid arthritis synovial tissues and synovial fluid.
Martin J. O’Brien, Qiang Shu, W.Alexander Stinson, Pei-Suen Tsou, Jeffrey H. Ruth, Takeo Isozaki, Phillip L. Campbell, Ray A. Ohara, Alisa E. Koch, David A. Fox, M. Asif Amin   +10 more
doaj   +1 more source

MicroRNA in autoimmunity and autoimmune diseases

Journal of Autoimmunity, 2009
MicroRNAs (miRNAs) are small conserved non-coding RNA molecules that post-transcriptionally regulate gene expression by targeting the 3' untranslated region (UTR) of specific messenger RNAs (mRNAs) for degradation or translational repression.
Department of Oral Surgery, Diagnostic Sciences, University of Florida, Gainesville, FL, USA ( host institution ), Pauley, Kaleb M., Cha, Seunghee, Chan, Edward K.L.   +4 more
openaire   +4 more sources

Myeloid-Derived Suppressor Cells Are Increased in Lung Transplant Recipients and Regulated by Immunosuppressive Therapy

Frontiers in Immunology, 2022
Lung transplantation remains as a primary treatment for end-stage lung diseases. Although remarkable improvement has been achieved due to the immunosuppressive protocols, long-term survival for lung transplant recipients (LTR) is still limited.
María Iglesias-Escudero, María Iglesias-Escudero, David San Segundo, David San Segundo, David Merino-Fernandez, Victor M. Mora-Cuesta, Patricia Lamadrid, Marta Alonso-Peña, Sandra Raso, David Iturbe, Sonia Fernandez-Rozas, Jose Cifrian, Marcos López-Hoyos, Marcos López-Hoyos, Marcos López-Hoyos   +14 more
doaj   +1 more source

Regulation of Syk activity by antiviral adaptor MAVS in FcεRI signaling pathway

Frontiers in Allergy, 2023
BackgroundMast cells are the major effector cell type for IgE-mediated allergic reactions. Recent studies revealed a role for mast cells in orchestrating the host response to viral infections.ObjectiveWe studied the relationship between FcεRI (high ...
Yuko Kawakami, Miho Kimura, Christella Widjaja, Kazumi Kasakura, Tomoaki Ando, Yu Kawakami, Joshua J. Obar, Toshiaki Kawakami   +7 more
doaj   +1 more source

Identification of commensal gut microbiota signatures as predictors of clinical severity and disease progression in multiple sclerosis

Scientific Reports
Multiple sclerosis (MS) is a chronic autoimmune disease of the central nervous system and a leading cause of neurological disability in young adults. Clinical presentation and disease course are highly heterogeneous. Typically, disease progression occurs
Theresa L. Montgomery, Qin Wang, Ali Mirza, Deanna Dwyer, Qi Wu, Catherine A. Dowling, Jacob W. S. Martens, Jennifer Yang, Dimitry N. Krementsov, Yang Mao-Draayer   +9 more
doaj   +1 more source

Bronchial extracellular matrix from COPD patients induces altered gene expression in repopulated primary human bronchial epithelial cells

Scientific Reports, 2018
Chronic obstructive pulmonary disease (COPD) is a serious global health problem characterized by chronic airway inflammation, progressive airflow limitation and destruction of lung parenchyma.
Ulf Hedström, Oskar Hallgren, Lisa Öberg, Amy DeMicco, Outi Vaarala, Gunilla Westergren-Thorsson, Xiaohong Zhou   +6 more
doaj   +1 more source

Comparison of Five Assays for the Detection of Anti-dsDNA Antibodies and Their Correlation with Complement Consumption

Diagnostics
Background: Anti-dsDNA is an important biomarker for the diagnosis, prognosis, and monitoring of systemic lupus erythematosus (SLE). Although several assays for anti-dsDNA antibody detection are routinely used, standardization remains limited, and ...
Vincent Ricchiuti, Jacob Obney, Brooke Holloway, Mary Ann Aure, Marti Shapiro, Chelsea Bentow, Michael Mahler   +6 more
doaj   +1 more source

Prolactin and Autoimmunity [PDF]

Frontiers in Immunology, 2018
The great asymmetry of autoimmune diseases between genders represents one of the most enigmatic observations among the mosaic of autoimmunity. Sex hormones are believed to play a crucial role on this dimorphism. The higher prevalence of autoimmunity among women at childbearing ages, disease onset/relapses during pregnancy, and post-partum are some of ...
Vânia Vieira Borba, Vânia Vieira Borba, Vânia Vieira Borba, Gisele Zandman-Goddard, Yehuda Shoenfeld, Yehuda Shoenfeld   +5 more
openaire   +5 more sources

Oxysterols in Autoimmunity [PDF]

International Journal of Molecular Sciences, 2019
Cholesterol is a member of the sterol family that plays essential roles in biological processes, including cell membrane stability and myelin formation. Cholesterol can be metabolized into several molecules including bile acids, hormones, and oxysterols. Studies from the last few decades have demonstrated that oxysterols are not only active metabolites
Donovan Duc, Solenne Vigne, Caroline Pot
openaire   +3 more sources