Results 171 to 180 of about 27,174 (202)

Autoinflammation by Endogenous DNA

2011
In various mammalian developmental processes such as programmed cell death, erythropoiesis, and lens-cell differentiation, chromosomal DNA is degraded into nucleotides by a set of specific nucleases. If this process does not proceed smoothly, the undigested DNA causes various problems. For example, when chromosomal DNA is not degraded in the lens cells,
Shigekazu, Nagata, Kohki, Kawane
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What’s new in autoinflammation?

Pediatric Nephrology, 2018
The pathogenesis of autoinflammatory diseases has shed light on the concept of inflammation in general and on our understanding of the role of the innate immune system. The autoinflammatory diseases have a large spectrum with varying features of inflammation. The most common autoinflammatory diseases are those associated with periodic fevers. The delay
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Epigenetics in Autoinflammation

2019
The molecular mechanisms of inflammation involve a series of processes that start as extracellular signals that interact with membrane-bound receptors, cell signaling cascades, nuclear factors, and epigenetic enzymes that activate a specific gene expression program.
Clara Lorente-Sorolla, Mihai G. Netea, Esteban Ballestar   +2 more
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Autoinflammation and Autoimmunity

2019
The elucidation of the genetic basis for hereditary recurrent fever syndromes validated the role of innate immune dysregulation in diseases formerly viewed as autoimmune. Recognizing the non-autoimmune nature of tumor necrosis factor receptor-associated periodic syndrome (TRAPS), one such syndrome, and the lack of evidence for autoantibodies or B- or T-
Dennis McGonagle, Abdulla Watad
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The role of ERAP1 in autoinflammation and autoimmunity

Human Immunology, 2019
Autoimmune and autoinflammatory diseases affect millions worldwide. These classes of disease involve abnormal immune activation of both the innate and adaptive immune systems. While both classes of disease represent a spectrum of aberrant immune activation, excessive activation of the innate immune system has been considered causal for the inflammation
Yuliya Pepelyayeva, Andrea Amalfitano
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Cytokines in Autoinflammation

2019
Autoinflammatory diseases represent an expanding spectrum of diseases characterized by recurrent episodes of fever and systemic inflammation, due to disorders of innate immunity. Since the concept of autoinflammation was first affirmed in 1999 to define TNF-receptor associated periodic syndrome (TRAPS), many other monogenic autoinflammatory diseases ...
Angela Rösen-Wolff, Anna Rubartelli
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Proteasomes in Autoinflammation

2019
The cellular proteostasis network integrates all signals controlling protein synthesis, folding, trafficking, and clearance machineries in multiple subcellular compartments to maintain the integrity of the proteome and to ensure the survival of cells and tissues under varying proteotoxic insults.
Anja Brehm, Frédéric Ebstein, Elke Krüger   +2 more
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Inflammasomes and Autoinflammation

2019
Inflammasomes are large intracellular multi-protein polymeric complexes comprised of sensors, adaptor proteins and caspases. As innate immune sensors capable of recognizing and rapidly responding to pathogen and metabolic danger signals, inflammasomes act as key modulators of initial immune responses.
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Panniculitis: A Cardinal Sign of Autoinflammation

Current Rheumatology Reviews
Abstract: Panniculitis was first described in the nineteenth century and is characterized by inflammation of the subcutaneous fat. It may be categorized in septal or lobular subtypes, but other histopathological features (e.g., presence of vasculitis, nature of inflammatory infiltrates, characteristics of fat necrosis) are also important for ...
Tiago Borges, Sérgio Silva
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Infektion oder Autoinflammation?

MMW - Fortschritte der Medizin, 2016
Geht akuter Durchfall mit Fieber und/oder Erbrechen einher, ist der „Normalfall“ eine Magen-Darm-Infektion durch Viren, Bakterien oder bakterielle Toxine. Als Ausloser kommen aber auch autoinflammatorische Pathologien infrage, wie chronisch-entzundliche Darmerkrankungen und die angeborenen hereditaren rekurrierenden Fiebersyndrome.
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