Results 161 to 170 of about 27,174 (202)
Understanding Human Autoimmunity and Autoinflammation Through Transcriptomics
Annual Review of Immunology, 2017 Transcriptomics, the high-throughput characterization of RNAs, has been instrumental in defining pathogenic signatures in human autoimmunity and autoinflammation.
Romain Banchereau +2 more
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Human TBK1 deficiency leads to autoinflammation driven by TNF-induced cell death
Cell, 2021 TANK binding kinase 1 (TBK1) regulates IFN-I, NF-κB, and TNF-induced RIPK1-dependent cell death (RCD). In mice, biallelic loss of TBK1 is embryonically lethal.
Michael Markson +2 more
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Inflammation, Autoinflammation and Autoimmunity in Inflammatory Bowel Diseases [PDF]
Current Issues in Molecular Biology, 2023 In this review, the role of innate and adaptive immunity in the pathogenesis of inflammatory bowel diseases (IBD) is reported. In IBD, an altered innate immunity is often found, with increased Th17 and decreased Treg cells infiltrating the intestinal ...
Daniela Basso +2 more
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The burgeoning field of innate immune-mediated disease and autoinflammation [PDF]
Journal of Pathology, 2017 Immune-mediated autoinflammatory diseases are occupying an increasingly prominent position among the pantheon of debilitating conditions that afflict mankind.
Daniel Peckham +2 more
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Autoinflammation: From monogenic syndromes to common skin diseases [PDF]
Journal of the American Academy of Dermatology, 2013 Autoinflammation is characterized by aberrant regulation of the innate immune system and often manifests as periodic fevers and systemic inflammation involving multiple organs, including the skin. Mutations leading to abnormal behavior or activity of the
Kieron S Leslie, Tien V Nguyen
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Autoinflammation in addition to combined immunodeficiency: SLC29A3 gene defect
Molecular Immunology, 2020 Introduction: H Syndrome is an autosomal recessive (AR) disease caused by defects in SLCA29A3 gene. This gene encodes the equilibrative nucleoside transporter, the protein which is highly expressed in spleen, lymph node and bone marrow.
Çağman Tan +2 more
exaly +2 more sources
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The role of mast cells in autoinflammation
Immunological Reviews, 2018SummaryThe concept of autoinflammation was proposed to define a new class of immune disorders categorized by self‐directed inflammation that is driven via activation of innate immune pathways. Within innate immunity, inflammasomes serve as intracellular signaling platforms to endogenous danger molecules and pathogens. Their key function is the cleavage
Naotomo Kambe +2 more
exaly +3 more sources
Autoinflammation and autoimmunity: Bridging the divide
Autoimmunity Reviews, 2012As soon as autoinflammatory diseases (AIDs) emerged as new entities, they have been linked to the well known world of autoimmunity. In fact, AIDs and systemic autoimmune diseases (ADs), share some characteristics: they start with the prefix "auto" to define a pathological process directed against self; they are systemic diseases, frequently involving ...
DORIA, ANDREA +8 more
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Broadening the definition of autoinflammation
Seminars in Immunopathology, 2015Initially, the concept of autoinflammation posited that there be no involvement of autoreactive B or T cells, and no evidence of infection. These criteria served well to help establish the concept, and distinguish autoinflammatory diseases from autoimmune or infectious conditions.
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