Results 11 to 20 of about 27,174 (202)
Immune Deficiency and Autoinflammation, the " Yin" and " Yang" of the Immune System
罕见病研究Inborn errors of immunity (IEI) are immune system disorders caused by genetic mutations, often presenting with varying degrees of infection, immune dysregulation, lymphoproliferation, and tumor susceptibility.
ZHOU Yu, SONG Hongmei
doaj +2 more sources
Autoinflammation: translating mechanism to therapy [PDF]
Journal of Leukocyte Biology, 2011 Autoinflammatory syndromes are a clinically heterogeneous collection of diseases characterized by dysregulation of the innate immune system. The hereditary recurrent fever disorders were the first to be defined as autoinflammatory.
Susannah D Brydges +2 more
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Autoinflammation und Autoimmunität
Arthritis und Rheuma, 2014 ZusammenfassungAutoinflammation wird definiert als selbstgerichtete Entzündung, bei der lokale Faktoren zu einer Aktivierung von Zellen des angeborenen Immunsystems führen, mit der Folge einer Schädigung des lokalen Gewebes, die aber auch von einer ...
K. Tenbrock
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Adult-onset autoinflammation caused by somatic mutations in UBA1:A Dutch case series of patients with VEXAS [PDF]
, 2022 Background: A novel autoinflammatory syndrome was recently described in male patients who harbored somatic mutations in the X-chromosomal UBA1 gene. These patients were characterized by adult-onset, treatment-refractory inflammation with fever, cytopenia,
Heijstek, Marloes +18 more
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The everchanging framework of autoinflammation [PDF]
Internal and Emergency Medicine, 2021 AbstractThe innate immunity works as a defence bullwark that safeguards healthy tissues with the power of detecting infectious agents in the human body: errors in the context of innate immunity identify autoinflammatory disorders (AIDs), which arise as bouts of aberrant inflammation with little or no involvement of T and B cells and neither recognized ...
Manna R, Rigante D
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<i>Candida oesophagitis</i> as an Initial Manifestation of VEXAS Syndrome: Expanding Evidence for an Acquired Immunodeficiency Phenotype. [PDF]
EJHaemeJHaem, Volume 7, Issue 4, August 2026.
Vintges DR, Weerheim M, Karim F.
europepmc +2 more sources
Journal of Clinical Medicine, 2021 In recent years, we have entered a new era full of insights into exciting pathways and improved management of a distinct class of inflammatory conditions [...]
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JAK inhibitors in autoinflammation [PDF]
Journal of Clinical Investigation, 2018 Interferonopathies are a subset of autoinflammatory disorders with a prominent type I IFN gene signature. Treatment of these patients has been challenging, given the lack of response to common autoinflammatory therapeutics including IL-1 and TNF blockade.
Hal M, Hoffman, Lori, Broderick
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Frontiers in Immunology, 2022 Autoinflammatory diseases are a group of clinical syndromes characterized by constitutive overactivation of innate immune pathways. This results in increased production of or responses to monocyte- and neutrophil-derived cytokines such as interleukin-1β (
McKella Sylvester +2 more
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Autoimmunity, Autoinflammation, and Infection in Uveitis [PDF]
American Journal of Ophthalmology, 2018 To review the pathogenesis of uveitis in light of recent advances in our understanding of innate and adaptive immune responses and their regulation.Perspective.Methods included a review of prevailing views on the pathogenesis of uveitis and an analysis of developments in immunology that impact on its conceptual basis, particularly the concept of ...
John V. Forrester +2 more
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