Results 11 to 20 of about 24,492 (179)
The everchanging framework of autoinflammation [PDF]
Internal and Emergency Medicine, 2021 AbstractThe innate immunity works as a defence bullwark that safeguards healthy tissues with the power of detecting infectious agents in the human body: errors in the context of innate immunity identify autoinflammatory disorders (AIDs), which arise as bouts of aberrant inflammation with little or no involvement of T and B cells and neither recognized ...
Manna R, Rigante D
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Journal of Clinical Medicine, 2021 In recent years, we have entered a new era full of insights into exciting pathways and improved management of a distinct class of inflammatory conditions [...]
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Still's Disease and Autoinflammation: Positioning an Inflammatory Syndrome on the Autoinflammation-Autoimmunity Spectrum. [PDF]
Curr Rheumatol RepAbstract Purpose of this Review Still’s disease exemplifies systemic inflammatory disorders existing on a continuum between autoinflammation and autoimmunity. This review examines Still’s disease through this spectrum lens, integrating recent advances in pathogenesis, clinical heterogeneity ...
Pietsch D, Savic S.
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JAK inhibitors in autoinflammation [PDF]
Journal of Clinical Investigation, 2018 Interferonopathies are a subset of autoinflammatory disorders with a prominent type I IFN gene signature. Treatment of these patients has been challenging, given the lack of response to common autoinflammatory therapeutics including IL-1 and TNF blockade.
Hal M, Hoffman, Lori, Broderick
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Autoimmunity, Autoinflammation, and Infection in Uveitis [PDF]
American Journal of Ophthalmology, 2018 To review the pathogenesis of uveitis in light of recent advances in our understanding of innate and adaptive immune responses and their regulation.Perspective.Methods included a review of prevailing views on the pathogenesis of uveitis and an analysis of developments in immunology that impact on its conceptual basis, particularly the concept of ...
John V. Forrester +2 more
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Living with autoinflammatory diseases: identifying unmet needs of children, adolescents and adults
Pediatric Rheumatology Online Journal, 2018 Background Autoinflammatory diseases (AIDs) illnesses of the innate immunity resulting in clinical signs and symptoms of systemic inflammation and loss of organ functions.
Gabriele Erbis +6 more
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Modern concept of autoimmunity in rheumatology
Научно-практическая ревматология, 2023 Two fundamental pathologic processes are central to the spectrum of chronic inflammation mechanisms: autoimmunity and autoinflammation. Autoimmunity and autoinflammation are mutually potent pathologic processes; their development is considered within the
E. L. Nasonov
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Alʹmanah Kliničeskoj Mediciny, 2018 The paper demonstrates current opportunities of effective management of periodic disease as an autoinflammatory disorder based on a clinical case of colchicine-resistant Mediterranean fever. We present modern approaches to the autoinflammation hypothesis
V. V. Rameev +3 more
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Lung Functioning and Inflammation in a Mouse Model of Systemic Juvenile Idiopathic Arthritis
Frontiers in Immunology, 2021 Systemic juvenile idiopathic arthritis (sJIA) is an immune disorder characterized by fever, skin rash, arthritis and splenomegaly. Recently, increasing number of sJIA patients were reported having lung disease.
Bert Malengier-Devlies +14 more
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Gene hunting in autoinflammation
Clinical and Translational Allergy, 2013 AbstractSteady progress in our understanding of the genetic basis of autoinflammatory diseases has been made over the past 16 years. Since the discovery of the familial Me diterranean f ev er gene MEFV (also known as marenostrin) in 1997, 18 other genes responsible for monogenic autoinflammatory diseases have been identified to date.
Standing, Ariane +2 more
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