Results 11 to 20 of about 24,725 (157)

Severe Gout During Arsenic Therapy: Insights on Oxidative Stress and Interleukin-1β in Gout. [PDF]

ACR Open Rheumatol
We report a 49‐year‐old male patient with a normal serum uric acid and recent diagnosis of acute promyelocytic leukemia (APL) who developed a severe polyarticular gout flare during treatment with arsenic trioxide (ATO). Unlike conventional chemotherapies, ATO acts through the generation of reactive oxygen species (ROS), leading to APL cell apoptosis ...
Hamilton J, Alexander A.
europepmc   +2 more sources

Still's Disease and Autoinflammation: Positioning an Inflammatory Syndrome on the Autoinflammation-Autoimmunity Spectrum. [PDF]

Curr Rheumatol Rep
Abstract Purpose of this Review Still’s disease exemplifies systemic inflammatory disorders existing on a continuum between autoinflammation and autoimmunity. This review examines Still’s disease through this spectrum lens, integrating recent advances in pathogenesis, clinical heterogeneity ...
Pietsch D, Savic S.
europepmc   +3 more sources

Autoinflammation: translating mechanism to therapy [PDF]

Journal of Leukocyte Biology, 2011
ABSTRACTAutoinflammatory syndromes are a clinically heterogeneous collection of diseases characterized by dysregulation of the innate immune system. The hereditary recurrent fever disorders were the first to be defined as autoinflammatory. Several of the responsible genes are now known to encode proteins forming multimeric complexes called ...
Taylor A, Doherty, Susannah D, Brydges, Hal M, Hoffman   +2 more
openaire   +3 more sources

Interleukin-1, inflammasomes, autoinflammation and the skin [PDF]

Swiss Medical Weekly, 2012
Interleukin 1, one of the first cytokines discovered in the 1980s, and a potent mediator of fever, pain and inflammation, is at present experiencing a revival in biology and medicine. Whereas the mechanism of activation and secretion of interleukin 1β, which critically regulates the function of this molecule, has remained mysterious for some 30 ...
Contassot Emmanuel, Beer Hans-Dietmar, French Lars E   +2 more
openaire   +4 more sources

The everchanging framework of autoinflammation [PDF]

Internal and Emergency Medicine, 2021
AbstractThe innate immunity works as a defence bullwark that safeguards healthy tissues with the power of detecting infectious agents in the human body: errors in the context of innate immunity identify autoinflammatory disorders (AIDs), which arise as bouts of aberrant inflammation with little or no involvement of T and B cells and neither recognized ...
Manna R, Rigante D
openaire   +3 more sources

Autoinflammation in der Dermatologie [PDF]

hautnah, 2017
Autoinflammatorische Syndrome sind seltene, meist monogenetisch bedingte Uberreaktionen des angeborenen Immunsystems, im Speziellen von Monozyten und Makrophagen (dies ist ein Gegensatz zur Autoimmunitat, bei der antigenspezifische Vertreter des erworbenen Immunsystems aktiv sind: T‑Zellen, B‑Zellen). Die Ursache liegt oft im sog. Inflammasom. Dies ist
Heil, Peter Maximilian, Peter Maximilian Heil   +1 more
openaire   +2 more sources

Autoinflammation It Is! [PDF]

Journal of Clinical Medicine, 2021
In recent years, we have entered a new era full of insights into exciting pathways and improved management of a distinct class of inflammatory conditions [...]
openaire   +2 more sources

Neuroinflammation, autoinflammation, splenomegaly and anemia caused by bi-allelic mutations in IRAK4 [PDF]

, 2023
We describe a novel, severe autoinflammatory syndrome characterized by neuroinflammation, systemic autoinflammation, splenomegaly, and anemia (NASA) caused by bi-allelic mutations in IRAK4.
Sancho-Shimizu, Vanessa, Paul Torpiano, Barbara Jensen, Hong, Ying, Evangelos Bellos, Bellos, Evangelos, Elizabeth Whittaker, Jensen, Barbara, Ying Hong, Ebun Omoyinmi, Whittaker, Elizabeth, Price-Kuehne, Fiona, Kshitij Mankad, Choi, Sangdun, Herberg, Jethro A., Mankad, Kshitij, Sangdun Choi, Despina Eleftheriou, Omoyinmi, Ebun, Bilal Ahmad, Eleftheriou, Despina, Austen J. J. Worth, Andrey Gagunashvili, Bahar, Mohammad W., Kaliakatsos, Marios, Gilmour, Kimberly C., Brogan, Paul A., Jethro A. Herberg, Kimberly C. Gilmour, Marios Kaliakatsos, Cooray, Samantha, Alice Burleigh, Torpiano, Paul, Worth, Austen J.J., Gagunashvili, Andrey, Burleigh, Alice, Fiona Price-Kuehne, Mohammad W. Bahar, Paul A. Brogan, Kumar, Atul, Vanessa Sancho-Shimizu, Samantha Cooray, Atul Kumar, Ahmad, Bilal, et al.   +44 more
core   +3 more sources

TRAP1 chaperone protein mutations and autoinflammation [PDF]

, 2020
We identified a consanguineous kindred, of three affected children with severe autoinflammation, resulting in the death of one sibling and allogeneic stem cell transplantation in the other two. All three were homozygous for MEFV p.S208C mutation; however,
McDermott, MF, Standing, ASI, Hong, Y, Omoyinmi, E, Medlar, A, Kleta, R, Brogan, PA, Paisan-Ruiz, C, Hawkins, P, Eleftheriou, D, Rowcenzio, D, Standing, AS, Klein, N, Stanescu, H, Lachmann, H   +14 more
core   +1 more source

JAK inhibitors in autoinflammation [PDF]

Journal of Clinical Investigation, 2018
Interferonopathies are a subset of autoinflammatory disorders with a prominent type I IFN gene signature. Treatment of these patients has been challenging, given the lack of response to common autoinflammatory therapeutics including IL-1 and TNF blockade.
Hal M, Hoffman, Lori, Broderick
openaire   +2 more sources